Engineering Orthogonal Upconversion through Selective Excitation in a Single Nanoparticle DOI

Jinshu Huang,

Zhengce An,

Yan Long

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(18)

Published: Feb. 20, 2023

Abstract Orthogonal upconversion with color‐switchable emissions under different excitation conditions provides new chances to diverse frontier applications of luminescent materials. However, the previous orthogonal systems compulsorily require precise control spatial distributions dopants and host compositions avoid spectral cross‐talk, greatly limiting their synthesis application. Herein, a conceptual design is presented realize by selectively activating sensitizers activators in nanostructure. In detail, 915 nm laser, instead mostly used 980 nm, adopted activate sensitizer Yb 3+ because broad 2 F 5/2 ← 7/2 absorption band; while it non‐responsive Er , consequently avoiding cross‐talk due simultaneous activation both irradiation as shown works. Such selective strategy able red/green, blue/red, blue/green single nanoparticle simply altering wavelength from 1530 nm. More interestingly, further allows for full‐color output temporal dynamics. The findings suggest facile but effective approach smart materials, showing great potential multi‐level anti‐counterfeiting, information security biological applications.

Language: Английский

Modular Engineering of DNAzyme-Based Sensors for Spatioselective Imaging of Metal Ions in Mitochondria DOI

Deyu Yi,

Hengzhi Zhao,

Jian Zhao

et al.

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 145(3), P. 1678 - 1685

Published: Dec. 27, 2022

DNAzyme-based sensors remain at the forefront of metal-ion imaging efforts, but most lack subcellular precision necessary to their applications in specific organelles. Here, we seek overcome this limitation by presenting a biosensor technology for spatiotemporally controlled metal ions mitochondria. A DNA nanodevice was constructed integrating an optically activatable DNAzyme sensor and upconversion nanoparticle with organelle-targeting signal. We exemplify that approach allows mitochondria-specific Zn2+ living cells near-infrared light-controlled manner. Based on this, system is used monitoring mitochondrial during drug treatment cellular model ischemia insult. Furthermore, employed assess dynamic change pharmacological interventions injury cell toxicity. This method paves way engineering investigate pathophysiological roles level.

Language: Английский

Citations

62
Spatiotemporally Selective Molecular Imaging via Upconversion Luminescence‐Controlled, DNA‐Based Biosensor Technology DOI
Jian Zhao, Zhenghan Di, Lele Li

et al.

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(32)

Published: June 6, 2022

DNA-based biosensor technologies have shown great potential in chemical and biological detection. These biosensors been actively developed as probes for molecular imaging live cells animals, allowing situ detection of analytes complex systems, elucidation the roles key molecules processes, development non-invasive diagnosis image-guided surgery. Despite progress made, improving spatial-temporal precision remains a challenge this field. In Minireview, we describe concepts behind spatiotemporally selective via combination engineered, light-activatable upconversion nanotechnology. We then highlight application approach controlled various targets specific intracellular organelles, signal amplification, well regulation targeting activity to receptor proteins. finally discuss challenges perspectives possible future developments emerging

Language: Английский

Citations

55
Controlling X-ray-activated persistent luminescence for emerging applications DOI
Hao Suo, Xin Zhang, Feng Wang

et al.

Trends in Chemistry, Journal Year: 2022, Volume and Issue: 4(8), P. 726 - 738

Published: May 31, 2022

Language: Английский

Citations

49
Dynamic–Reversible MRI Nanoprobe for Continuous Imaging Redox Homeostasis in Hepatic Ischemia–Reperfusion Injury DOI
Cheng Zhang, Li Xu,

Bin Nan

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9529 - 9542

Published: May 8, 2023

Hepatic ischemia–reperfusion (I/R) injury accompanied by oxidative stress is responsible for postoperative liver dysfunction and failure of surgery. However, the dynamic non-invasive mapping redox homeostasis in deep-seated during hepatic I/R remains a great challenge. Herein, inspired intrinsic reversibility disulfide bond proteins, kind reversible redox-responsive magnetic nanoparticles (RRMNs) designed imaging both oxidant antioxidant levels (ONOO–/GSH), based on sulfhydryl coupling/cleaving reaction. We develop facile strategy to prepare such MRI nanoprobe via one-step surface modification. Owing significant change size response, sensitivity RRMNs greatly improved, which enables monitor tiny injury. Notably, can non-invasively visualize tissue slice living mice. Moreover, this not only report molecular information about degree but also provide anatomical where pathology occurred. The probe promising accurately facilely monitoring process, accessing developing powerful precise treatment.

Language: Английский

Citations

36
Engineering Orthogonal Upconversion through Selective Excitation in a Single Nanoparticle DOI

Jinshu Huang,

Zhengce An,

Yan Long

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(18)

Published: Feb. 20, 2023

Abstract Orthogonal upconversion with color‐switchable emissions under different excitation conditions provides new chances to diverse frontier applications of luminescent materials. However, the previous orthogonal systems compulsorily require precise control spatial distributions dopants and host compositions avoid spectral cross‐talk, greatly limiting their synthesis application. Herein, a conceptual design is presented realize by selectively activating sensitizers activators in nanostructure. In detail, 915 nm laser, instead mostly used 980 nm, adopted activate sensitizer Yb 3+ because broad 2 F 5/2 ← 7/2 absorption band; while it non‐responsive Er , consequently avoiding cross‐talk due simultaneous activation both irradiation as shown works. Such selective strategy able red/green, blue/red, blue/green single nanoparticle simply altering wavelength from 1530 nm. More interestingly, further allows for full‐color output temporal dynamics. The findings suggest facile but effective approach smart materials, showing great potential multi‐level anti‐counterfeiting, information security biological applications.

Language: Английский

Citations

34