Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations DOI

Yan Mao,

Wenxi Chen, Changchang Li

и другие.

Chemical Communications, Год журнала: 2023, Номер 59(25), С. 3775 - 3778

Опубликована: Янв. 1, 2023

An efficient method for the construction of various 3,4,5-trisubstituted phenol derivatives has been achieved via Rh(III)-catalyzed coupling phosphonium cations with internal alkynes. This protocol shows good substrate compatibility, as an array structurally and electronically diverse compounds react efficiently up to 87% yield.

Язык: Английский

Merging directed sp3 and nondirected sp2 C–H functionalization for Pd-catalyzed polydeuteration of (hetero)arenes DOI Creative Commons
Soo Eun Park, Sungjun Choi,

Chaehun Lim

и другие.

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A ligand-enabled strategy achieves deuteration with high deuterium enrichment through both directed sp 3 and nondirected 2 C–H deuteration.

Язык: Английский

Процитировано

0
Palladium/Xu‐Phos‐Catalyzed Enantioselective Cascade Heck/Intermolecular Direct Heteroarylation Reaction DOI

Kexin Dong,

Chao Fang,

Zhongyu Li

и другие.

Chinese Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 29, 2025

Comprehensive Summary Asymmetric cascade Heck/C–H functionalization has emerged as an appealing strategy for activating inert C–H bonds and conveniently synthesizing heterocycles with quaternary centers, owing to the domino sequence of carbopalladation followed by enabling efficient construction multiple in one pot. Herein, a palladium‐catalyzed enantioselective Heck/intermolecular direct heteroarylation reaction unactivated alkenes heteroarenes is developed, providing facile access diverse bis‐heterocycles great practicality bearing all‐carbon stereocenter excellent levels yields enantioselectivities under mild conditions. Moreover, synthetic utility this further demonstrated versatile transformations product.

Язык: Английский

Процитировано

0
Unlocking Regiodivergence in PdII- and RhIII-Mediated Site-Selective C–H Bond Alkynylation of Imidazopyridines DOI
Qiang Zhang,

Xuecong Huang,

Yuting Gui

и другие.

Organic Letters, Год журнала: 2023, Номер 25(9), С. 1447 - 1452

Опубликована: Фев. 24, 2023

An efficient PdII- and RhIII-controlled site-selective C-H bond alkynylation of imidazopyridines using (bromoethynyl)triisopropylsilane is disclosed. The divergent methodology allows straightforward access to a wide range products alkynylated at the C3 ortho positions. This strategy suggestive practical platform that can be suitable for late-stage diversification may assist in design more selective complementary catalytic systems.

Язык: Английский

Процитировано

8
Cascade Alkenylation/Intramolecular Friedel–Crafts Alkylation: High Selectivity at the C7-Position of BINOL DOI
Hao Liu,

Zi‐Rong Gong,

Yu Zhao

и другие.

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(9), С. 6108 - 6119

Опубликована: Апрель 3, 2023

An efficient and straightforward approach for the synthesis of C7 site-selective BINOL derivatives has been achieved via cost-effective Co(III)-catalyzed C-H cascade alkenylation/intramolecular Friedel-Crafts alkylation units propargyl cycloalkanols. Under advantage pyrazole directing group, protocol allows rapid various BINOL-tethered spiro[cyclobutane-1,1'-indenes].

Язык: Английский

Процитировано

8
Synthesis of 3,4,5-trisubstituted phenols via Rh(iii)-catalyzed alkenyl C–H activation assisted by phosphonium cations DOI

Yan Mao,

Wenxi Chen, Changchang Li

и другие.

Chemical Communications, Год журнала: 2023, Номер 59(25), С. 3775 - 3778

Опубликована: Янв. 1, 2023

An efficient method for the construction of various 3,4,5-trisubstituted phenol derivatives has been achieved via Rh(III)-catalyzed coupling phosphonium cations with internal alkynes. This protocol shows good substrate compatibility, as an array structurally and electronically diverse compounds react efficiently up to 87% yield.

Язык: Английский

Процитировано

7