C–H activation-initiated spiroannulation reactions and their applications in the synthesis of spirocyclic compounds

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(12), С. 2324 - 2338

Опубликована: Янв. 1, 2024

This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications construction of structurally diverse biologically valuable spirocyclic scaffolds.

Язык: Английский

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Regioselective Substitution of BINOL

Chemical Reviews, Год журнала: 2024, Номер 124(10), С. 6643 - 6689

Опубликована: Май 9, 2024

1,1′-Bi-2-naphthol (BINOL) has been extensively used as the chirality source in fields of molecular recognition, asymmetric synthesis, and materials science. The direct electrophilic substitution at aromatic rings optically active BINOL developed one most convenient strategies to structurally modify for diverse applications. High regioselectivity achieved reaction with electrophiles. Depending upon conditions patterns, various functional groups can be introduced specific positions, such 6-, 5-, 4-, 3-positions, BINOL. Ortho-lithiation 3-position directed by 2-position have prepare 3- 3,3′-substituted BINOLs. use transition metal-catalyzed C–H activation also explored functionalize 3-, 7-positions. These regioselective substitutions allowed construction tremendous amount derivatives fascinating structures properties reviewed this article. Examples applications BINOLs varying catalysis, chiral sensing are provided.

Язык: Английский

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Synthesis and growth of solution-processed chiral perovskites

Journal of Physics Energy, Год журнала: 2024, Номер 6(4), С. 042001 - 042001

Опубликована: Авг. 12, 2024

Abstract In materials science, chiral perovskites stand out due to their exceptional optoelectronic properties and the versatility in structure composition, positioning them as crucial advances of technologies spintronics chiroptical systems. This review underlines critical role synthesizing growing these materials, a process integral leveraging complex interplay between structural chirality distinctive properties, including chiral-induced spin selectivity activity. The paper offers comprehensive summary discussion methods used synthesis growth perovskites, delving into extensive techniques, fundamental mechanisms, strategic approaches for engineering low-dimensional alongside creation novel ligands. necessity developing new synthetic maintaining precise control during is emphasized, aiming enhance boost efficiency selectivity.

Язык: Английский

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Copper-Promoted ortho-Directed C-H Amination of 2-Arylpyridines with NH-heterocycles

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(36), С. 7390 - 7394

Опубликована: Янв. 1, 2024

Copper-mediated C–N coupling of azaheterocycles with aryl C–H bonds has been realized for the synthesis N-(hetero)arylated heteroarenes.

Язык: Английский

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The Construction of Novel Spirocyclic Frameworks with Cyclobutane through Rh(III)-Catalyzed [3 + 2]-Annulation between Quinoxalines and Alkynylcyclobutanols

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(18), С. 12912 - 12923

Опубликована: Сен. 3, 2024

An effective synthesis strategy for the preparation of 1'

Язык: Английский

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Rh(III)‐Catalyzed Annulative Coupling of Sulfoxonium Ylides with Allyl Acetates: Generation of Bicyclo[4.1.0]heptan‐2‐ones

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(28)

Опубликована: Июнь 7, 2023

Abstract A highly efficient Rhodium(III)‐catalyzed annulative coupling was developed for generating bicyclo[4.1.0] heptan‐2‐ones from sulfoxonium ylides and allyl acetates under mild conditions. This cascade reaction is versatile to construct cyclopropanes, the starting materials are stable easily obtainable.

Язык: Английский

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Rh(III)-catalyzed [4 + 1] annulation of 1-arylindazolones with alkynyl cyclobutanols: access to indazolo[1,2-a]indazolones

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(32), С. 6500 - 6505

Опубликована: Янв. 1, 2024

A convenient and efficient synthesis of structurally diverse indazolo[1,2- a ]indazolones via Rh( iii )-catalyzed [4 + 1] annulation 1-arylindazolones with alkynyl cyclobutanols has been achieved by combining C–H C–C bond cleavage.

Язык: Английский

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Sulfonylpyrazole- and pyrazole-directed ortho-selective C–H functionalization/alkenylation and desulfenylative olefination of aryl(sulfonyl)pyrazoles

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(41), С. 8301 - 8305

Опубликована: Янв. 1, 2023

ortho -Selective C–H alkenylation of arenes was achieved using (sulfonyl)pyrazoles as DGs, favored by combination Pd(OAc) 2 Boc-Sar-OH and silver acetate. Silver tetrafluoroborate gave de-sulfenylative olefinated products on sulfonylpyrazole.

Язык: Английский

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