Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer,
with
its
diversity,
heterogeneity,
and
complexity,
is
a
significant
contributor
to
global
morbidity,
disability,
mortality,
highlighting
the
necessity
for
transformative
treatment
approaches.
Photodynamic
therapy
(PDT)
has
aroused
continuous
interest
as
viable
alternative
conventional
cancer
treatments
that
encounter
drug
resistance.
Nanotechnology
brought
new
advances
in
medicine
shown
great
potential
delivery
treatment.
For
precise
efficient
therapeutic
utilization
of
such
tumor
approach
high
spatiotemporal
selectivity
minimal
invasiveness,
carrier-free
noncovalent
nanoparticles
(NPs)
based
on
chemo-photodynamic
combination
essential.
Utilizing
natural
products
foundation
nanodrug
development
offers
unparalleled
advantages,
including
exceptional
pharmacological
activity,
easy
functionalization/modification,
well
biocompatibility.
The
natural-product-based,
carrier-free,
NPs
revealed
excellent
synergistic
anticancer
activity
comparison
free
photosensitizers
bioactive
products,
representing
an
favorable
avenue
improve
efficacy.
Herein,
comprehensive
summary
current
strategies
representative
application
examples
past
decade
(such
paclitaxel,
10-hydroxycamptothecin,
doxorubicin,
etoposide,
combretastatin
A4,
epigallocatechin
gallate,
curcumin)
therapy.
We
highlight
insightful
design
synthesis
smart
aim
enhance
PDT
Meanwhile,
we
discuss
future
challenges
opportunities
associated
these
provide
enlightenment,
spur
innovative
ideas,
facilitate
PDT-mediated
clinical
transformation.
Chemical Communications,
Год журнала:
2023,
Номер
59(52), С. 8127 - 8130
Опубликована: Янв. 1, 2023
A
simple
yet
powerful
D-A
type-based
NIR-II
fluorophore
(MTF)
with
mitochondria
targeting
was
constructed.
This
mitochondrial
dye
MTF
exhibited
not
only
a
photothermal
effect
but
also
photodynamic
performance,
and
further
fabricated
DSPE-mPEG
to
generate
nanodots
for
in
vivo
experiments,
achieving
strong
fluorescence
tracing
of
tumors
impressive
image-guided
therapy
(PDT)
(PTT).
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(17)
Опубликована: Март 8, 2024
Although
being
applied
as
photosensitizers
for
photodynamic
therapy,
covalent
organic
frameworks
(COFs)
fail
the
precise
fluorescence
imaging
in
vivo
and
phototherapy
deep-tissue,
due
to
short
excitation/emission
wavelengths.
Herein,
this
work
proposes
first
example
of
NIR-II
emissive
benzobisthiadiazole-based
COF-980.
Comparing
its
ligands,
structure
COF-980
can
more
efficiently
reducing
energy
gap
(ΔE
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 10, 2024
Abstract
The
development
of
Type
I
photosensitizers
(PSs)
is
great
importance
due
to
the
inherent
hypoxic
intolerance
photodynamic
therapy
(PDT)
in
microenvironment.
Compared
II
PSs,
PSs
are
less
reported
absence
a
general
molecular
design
strategy.
Herein,
we
report
that
combination
typical
PS
and
natural
substrate
carvacrol
(CA)
can
significantly
facilitate
pathway
efficiently
generate
superoxide
radical
(O
2
–•
).
Detailed
mechanism
study
suggests
CA
activated
into
thymoquinone
(TQ)
by
local
singlet
oxygen
generated
from
upon
light
irradiation.
With
TQ
as
an
efficient
electron
transfer
mediator,
it
promotes
conversion
O
via
transfer-based
pathway.
Notably,
three
classical
employed
demonstrate
universality
proposed
approach.
PDT
against
S.
aureus
has
been
demonstrated
under
conditions
vitro.
Furthermore,
this
coupled
agent
exhibits
significant
bactericidal
activity
with
antibacterial
rate
99.6%
for
bacterial-infection
female
mice
vivo
experiments.
Here,
show
simple,
effective,
universal
method
endow
traditional
tolerance.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107150 - 107150
Опубликована: Март 21, 2024
Cancer,
with
its
diversity,
heterogeneity,
and
complexity,
is
a
significant
contributor
to
global
morbidity,
disability,
mortality,
highlighting
the
necessity
for
transformative
treatment
approaches.
Photodynamic
therapy
(PDT)
has
aroused
continuous
interest
as
viable
alternative
conventional
cancer
treatments
that
encounter
drug
resistance.
Nanotechnology
brought
new
advances
in
medicine
shown
great
potential
delivery
treatment.
For
precise
efficient
therapeutic
utilization
of
such
tumor
approach
high
spatiotemporal
selectivity
minimal
invasiveness,
carrier-free
noncovalent
nanoparticles
(NPs)
based
on
chemo-photodynamic
combination
essential.
Utilizing
natural
products
foundation
nanodrug
development
offers
unparalleled
advantages,
including
exceptional
pharmacological
activity,
easy
functionalization/modification,
well
biocompatibility.
The
natural-product-based,
carrier-free,
NPs
revealed
excellent
synergistic
anticancer
activity
comparison
free
photosensitizers
bioactive
products,
representing
an
favorable
avenue
improve
efficacy.
Herein,
comprehensive
summary
current
strategies
representative
application
examples
past
decade
(such
paclitaxel,
10-hydroxycamptothecin,
doxorubicin,
etoposide,
combretastatin
A4,
epigallocatechin
gallate,
curcumin)
therapy.
We
highlight
insightful
design
synthesis
smart
aim
enhance
PDT
Meanwhile,
we
discuss
future
challenges
opportunities
associated
these
provide
enlightenment,
spur
innovative
ideas,
facilitate
PDT-mediated
clinical
transformation.
