Pharmaceutics,
Год журнала:
2023,
Номер
15(7), С. 1840 - 1840
Опубликована: Июнь 27, 2023
Hypoxia,
a
deficiency
in
the
levels
of
oxygen,
is
common
feature
most
solid
tumors
and
induces
many
characteristics
cancer.
Hypoxia
associated
with
metastases
strong
resistance
to
radio-
chemotherapy,
can
decrease
accuracy
cancer
prognosis.
Non-invasive
imaging
methods
such
as
positron
emission
tomography
(PET)
single-photon
computed
(SPECT)
using
hypoxia-targeting
radiopharmaceuticals
have
been
used
for
detection
therapy
tumor
hypoxia.
Nitroimidazoles
are
bioreducible
moieties
that
be
selectively
reduced
under
hypoxic
conditions
covalently
bind
intracellular
macromolecules,
trapped
within
cells
tissues.
Recently,
there
has
motivation
develop
PET
SPECT
radiotracers
containing
nitroimidazole
visualization
treatment
tumors.
In
this
review,
we
summarize
development
some
novel
nitroimidazoles,
well
their
physicochemical
properties,
vitro
cellular
uptake
values,
vivo
biodistribution,
PET/SPECT
results.
Chemistry - A European Journal,
Год журнала:
2023,
Номер
29(35)
Опубликована: Апрель 20, 2023
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
and
the
main
cause
of
dementia
worldwide.
As
pathogenesis
AD
quite
complicated,
there
continuous
attention
to
AD-associated
active
species,
such
as
amyloid-β
plaques,
neurofibrillary
tangles,
metal
ions,
reactive
oxygen/nitrogen/sulphur
cholinesterase,
viscosity,
formaldehyde
so
on.
To
this
end,
series
small
molecular
fluorescent
probes
for
these
species
have
been
explored
early
diagnosis
even
remedy
AD.
Herein,
we
systematacially
summarize
versatile
mainly
in
recent
three
years,
including
relationship
between
structure
properties
well
targeted
imaging
application
all
probes.
Moreover,
challenges
perspectives
AD-related
are
briefly
explicated.
We
firmly
expect
review
may
provide
guidance
constructing
new
AD-relevant
promote
clinical
study
Analytical Chemistry,
Год журнала:
2024,
Номер
96(14), С. 5437 - 5445
Опубликована: Март 26, 2024
The
research
on
fluorescent
rotors
for
viscosity
has
attracted
extensive
interest
to
better
comprehend
the
close
relationships
of
microviscosity
variations
with
related
diseases.
Although
scientists
have
made
great
efforts,
probes
cellular
both
aggregation-induced
emissions
(AIEs)
and
large
Stokes
shifts
improve
sensing
properties
rarely
been
reported.
Herein,
we
first
report
four
new
meso-C═N-substituted
BODIPY-based
shifts,
investigate
their
viscosity/AIE
characteristics,
perform
imaging
in
subcellular
organelles.
Interestingly,
meso-C═N-phenyl
group-substituted
probe
6
showed
an
obvious
594
nm
fluorescence
enhancement
glycerol
a
moderate
650
red
AIE
emission
water.
Further,
attaching
CF3
phenyl
group,
similar
phenomenon
was
observed
7
red-shifted
emissions,
attributed
introduction
which
plays
key
role
shifts.
Comparatively,
phenyl-group-free
probes,
meso-C═N-trifluoroethyl
group
thiazole-substituted
(8
9)
exhibited
good
viscosity-responsive
properties,
while
no
due
absence
groups.
For
experiments,
9
lysosomal
mitochondrial
targeting
respectively,
were
further
successfully
used
through
preincubation
monensin
lipopolysaccharide
(LPS),
indicating
that
C═N
polar
groups
potentially
work
as
rotatable
moieties
organelle-targeting
groups,
difference
might
be
ascribed
increased
charges
thiazole.
Therefore,
this
study,
investigated
structural
meso-C═N
respect
subcellular-targeting
ability,
viscosity,
serving
imaging.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(18)
Опубликована: Март 29, 2024
The
synthesis
of
water-soluble
symmetric
molecules
with
donor-acceptor-donor
(D-A-D)
structure
is
reported.
compound
connected
by
π
bridge
2-bromofluorene
external
polyethylene
glycol
2000
as
the
shielding
unit,
and
donor
component
pyrrolopyrrole
(DPP)
acceptor
unit.
D-A-D
double
fluorescent
molecule
P2-DPP
obtained
coupling
reaction.
absorption
peak
emission
are
600
1020
nm,
respectively.
It
has
potential
excellent
imaging
characteristics.
does
not
need
to
use
nanoparticles
formed
DSPE-MPEG
amphiphilic
block
form
micelles.
quantum
yield
reaches
0.6%
penetration
depth
can
reach
10
mm.
chemical
capable
achieving
liver
renal
metabolism.
a
good
application
prospect
in
photothermal
therapy
mouse
tumors
realizes
integration
biological
diagnosis
treatment.
International Journal of Polymeric Materials,
Год журнала:
2024,
Номер
unknown, С. 1 - 25
Опубликована: Окт. 24, 2024
A
Comprehensive
Review
delves
into
the
evolution
of
carboxymethyl
cellulose
(CMC)
modifications
and
their
extensive
utilization
in
biomedical
fields.
Various
cross-linking
agents
methods
such
as
physical,
chemical,
photo,
enzymatic
are
explored
for
enhancing
CMC
properties.
This
modified
exhibits
notable
antimicrobial
antifungal
activities,
rendering
it
pivotal
pharmaceutical
formulations.
Moreover,
its
versatility
extends
to
applications
including
drug
delivery,
tissue
engineering,
wound
dressing,
regenerative
medicine,
bioimaging,
biosensing,
diagnosis,
Vaccine
immunotherapy
other
therapeutic
purposes.
review
provides
a
thorough
insight
multifaceted
roles
contemporary
sciences.
Analytical Chemistry,
Год журнала:
2024,
Номер
96(18), С. 7138 - 7144
Опубликована: Апрель 27, 2024
Superoxide
anion
(O2·–)
and
peroxynitrite
(ONOO–),
two
important
oxidants
under
oxidative
stress,
coexist
in
complex
cell
organism
systems,
playing
crucial
roles
various
physiological
pathological
processes,
particularly
neurodegenerative
diseases.
Despite
the
absence
of
robust
molecular
tools
capable
simultaneously
visualizing
O2·–
ONOO–
biosystems,
relationship
between
these
species
remains
understudied.
Herein,
we
present
sequentially
activated
fluorescent
probe,
DHX-SP,
which
exhibits
exceptional
selectivity
sensitivity
toward
ONOO–.
This
probe
enables
precise
imaging
living
PC12
cells
stress
conditions
using
distinct
fluorescence
signal
combinations.
Furthermore,
DHX-SP
has
ability
to
visualize
changes
levels
during
ferroptosis
Parkinson's
disease
model.
These
findings
establish
a
connection
crosstalk
phosphorus
group
stress.
