Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Lanthanide‐based
luminescence
nanothermometry
has
demonstrated
unprecedented
advantages
in
the
development
of
nanotheranostic
platforms
for
potential
medical
applications,
yet
despite
exponential
research
progress
and
great
enthusiasm
across
various
related
disciplines,
a
swift
bench‐to‐bedside
translation
seems
to
be
still
out
reach.
This
is
predominantly
fundamental
issues
at
preclinical
stage,
such
as
complex
nanomaterials
design,
incomplete
optimization,
fragmented
characterization,
insufficient
validation
nanothermometer
performance
physiological
environments.
The
main
impediments
currently
are
important
biophysicochemical
that
must
addressed
comprehensively,
first
foremost
available
vitro
systems,
before
going
on
vivo
investigations.
review
outlines
critical
perspective,
well
route
suggestions
underexplored
aspects
address
significantly
minimize
existing
translational
gap.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Фев. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
Advanced Materials,
Год журнала:
2024,
Номер
36(30)
Опубликована: Май 11, 2024
Abstract
The
spotlight
has
shifted
to
near‐infrared
(NIR)
luminescent
materials
emitting
beyond
1000
nm,
with
growing
interest
due
their
unique
characteristics.
ability
of
NIR‐II
emission
(1000–1700
nm)
penetrate
deeply
and
transmit
independently
positions
these
NIR
for
applications
in
optical‐communication
devices,
bioimaging,
photodetectors.
combination
rare
earth
metals/transition
metals
a
variety
matrix
provides
new
platform
creating
chemical
physical
properties
science
device
applications.
In
this
review,
the
recent
advancements
activated
by
transition
metal
ions
are
summarized
role
spanning
sensing,
optoelectronics
is
illustrated.
It
started
various
synthesis
techniques
explored
how
earths/transition
can
be
skillfully
incorporated
into
matrixes,
thereby
endowing
them
discussion
strategies
enhancing
excitation
absorption
efficiency,
spotlighting
innovations
like
dye
sensitization
surface
plasmon
resonance
effects
then
extended.
Subsequently,
significant
focus
placed
on
functionalization
Finally,
comprehensive
analysis
challenges
proposed
earth/transition
ion‐doped
materials,
summarizing
insights
each
section
provided.
Advanced Materials,
Год журнала:
2023,
Номер
36(2)
Опубликована: Сен. 25, 2023
Unsatisfied
tumor
accumulation
of
chemotherapeutic
drugs
and
a
complicated
immunosuppressive
microenvironment
diminish
the
immune
response
rate
therapeutic
effect.
Surface
modification
these
with
target
ligands
can
promote
their
cellular
internalization,
but
modified
may
be
subjected
to
unexpected
recognition
clearance.
Herein,
phenylboronic
acid
(PBA)
group-shieldable
dendritic
nanomedicine
that
integrates
an
immunogenic
cell
death
(ICD)-inducing
agent
(epirubicin,
Epi)
indoleamine
2,3-dioxgenase
1
(IDO1)
inhibitor
(NLG919)
is
reported
for
chemo-immunotherapy.
This
NLG919-loaded
Epi-conjugated
PEGylated
dendrimers
bridged
boronate
bonds
(NLG919@Epi-DBP)
maintains
stable
nanostructure
during
circulation.
Under
moderate
acidic
condition,
PBA
group
exposes
sialic
residue
on
membrane
enhance
internalization
penetration
NLG919@Epi-DBP.
At
pH
5.0,
NLG919@Epi-DBP
rapidly
disassembles
release
incorporated
Epi
NLG919.
triggers
robust
ICD
cells
evokes
strong
response.
In
addition,
inhibition
IDO1
activity
downregulates
metabolism
L-tryptophan
kynurenine,
leading
reduction
in
recruitment
modulation
microenvironment.
Collectively,
this
promising
strategy
has
been
demonstrated
evoke
as
well
remodel
enhanced
chemo-immunotherapeutic
Abstract
Cancer
cells
typically
display
redox
imbalance
compared
with
normal
due
to
increased
metabolic
rate,
accumulated
mitochondrial
dysfunction,
elevated
cell
signaling,
and
accelerated
peroxisomal
activities.
This
may
regulate
gene
expression,
alter
protein
stability,
modulate
existing
cellular
programs,
resulting
in
inefficient
treatment
modalities.
Therapeutic
strategies
targeting
intra‐
or
extracellular
states
of
cancer
at
varying
state
progression
trigger
programmed
death
if
exceeded
a
certain
threshold,
enabling
therapeutic
selectivity
overcoming
resistance
radiotherapy
chemotherapy.
Nanotechnology
provides
new
opportunities
for
modulating
their
excellent
designability
high
reactivity.
Various
nanomaterials
are
widely
researched
enhance
highly
reactive
substances
(free
radicals)
production,
disrupt
the
endogenous
antioxidant
defense
systems,
both.
Here,
physiological
features
described
challenges
illustrated.
Then,
that
classified
elaborated
upon
based
on
ability
target
regulations.
Finally,
future
perspectives
this
field
proposed.
It
is
hoped
review
guidance
design
nanomaterials‐based
approaches
involving
therapy,
especially
cancers
resistant
chemotherapy,
etc.
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
508, С. 215773 - 215773
Опубликована: Март 14, 2024
Phototherapy,
using
light
as
a
therapeutic
modality,
has
been
widely
applied
in
treating
various
diseases,
especially
cancer.
This
approach
is
valued
for
its
non-invasive
nature
and
minimal
risk
of
drug
resistance.
However,
phototherapy
faces
challenges
such
the
undesired
delivery
phototherapeutic
agents,
potential
phototoxicity,
limited
penetration
into
tissues.
Lanthanide-doped
nanoparticles
offer
attractive
opportunities
to
improve
efficacy
photodynamic
therapy.
These
are
distinguished
by
their
unique
optical
properties,
excellent
photostability
against
blinking
bleaching
effects,
large
Stokes
or
anti-Stokes
shifts,
sharp
emission
peaks,
long
luminescence
lifetimes.
In
addition,
lanthanide-doped
can
be
excited
near-infrared
(NIR)
X-rays,
enabling
deep-tissue
penetration.
Beyond
use
photosensitizers,
nanoparticle
surfaces
easily
modified
with
targeting
ligands,
chemical
drugs,
functional
molecules
enhance
effectiveness
enable
combination
this
review,
we
organize
lanthanide-based
tumor
six
main
domains:
therapy,
photothermal
X-ray-based
light-controlled
photoimmunotherapy,
other
innovative
treatments
that
regulated
light.
We
introduce
basic
principles
characteristics
lanthanide
nanoparticles.
Following
this,
summarize
latest
advances
utilizing
phototherapy,
focusing
on
design
principles,
mechanisms
action,
cancer
treatment.
To
conclude,
address
existing
explore
future
within
area
research.
ACS Nano,
Год журнала:
2023,
Номер
17(24), С. 24883 - 24900
Опубликована: Окт. 26, 2023
Surgical
resection
is
the
first-line
therapy
for
breast
cancer.
However,
residual
tumor
cells
and
highly
immunosuppressive
microenvironment
(TME)
continue
to
have
a
serious
impact
on
recurrence
metastasis
postresection.
Implantation
of
an
Antioxidants,
Год журнала:
2024,
Номер
13(2), С. 213 - 213
Опубликована: Фев. 8, 2024
This
study
used
a
sonochemical
synthesis
method
to
prepare
(La,
Sm)-doped
ZnO
nanoparticles
(NPs).
The
effect
of
incorporating
these
lanthanide
elements
on
the
structural,
optical,
and
morphological
properties
ZnO-NPs
was
analyzed.
cytotoxicity
reactive
oxygen
species
(ROS)
generation
capacity
were
evaluated
against
breast
(MCF7)
colon
(HT29)
cancer
cell
lines.
Their
antioxidant
activity
analyzed
using
DPPH
assay,
their
toxicity
towards
Artemia
salina
nauplii
also
evaluated.
results
revealed
that
treatment
with
NPs
resulted
in
death
10.559–42.546%
18.230–38.643%
MCF7
HT29
cells,
respectively.
attributed
ability
downregulate
ROS
formation
within
two
lines
dose-dependent
manner.
In
inhibited
free
radicals
at
IC50
values
ranging
from
3.898
126.948
μg/mL.
Against
A.
nauplii,
synthesized
did
not
cause
nor
induce
changes
tested
concentrations.
A
series
machine
learning
(ML)
models
predict
biological
performance
ZnO-NPs.
Among
designed
ML
models,
gradient
boosting
model
greatest
mean
absolute
error
(MAE)
(MAE
9.027,
R2
=
0.86).
data
generated
this
work
provide
innovative
insights
into
influence
La
Sm
structural
arrangement
chemical
features
ZnO-NPs,
together
cytotoxicity,
activity,
vivo
toxicity.
Nanomaterials,
Год журнала:
2024,
Номер
14(3), С. 296 - 296
Опубликована: Янв. 31, 2024
Injectable
colloidal
solutions
of
lanthanide
oxides
(nanoparticles
between
10
and
100
nm
in
size)
have
demonstrated
high
biocompatibility
no
toxicity
when
the
nanoparticulate
units
are
functionalized
with
specific
biomolecules
that
molecularly
target
various
proteins
tumor
microenvironment.
Among
successfully
targeted
by
nanoparticles
folic
receptors,
fibroblast
activation
protein
(FAP),
gastrin-releasing
peptide
receptor
(GRP-R),
prostate-specific
membrane
antigen
(PSMA),
integrins
associated
neovasculature.
Lutetium,
samarium,
europium,
holmium,
terbium,
either
as
oxide
or
doped
ions,
their
theranostic
potential
through
ability
to
generate
molecular
images
magnetic
resonance,
nuclear,
optical,
computed
tomography
imaging.
Likewise,
photodynamic
therapy,
radiotherapy
(neutron-activated
nanoparticles),
drug
delivery
guidance,
image-guided
therapy
some
examples
therapeutic
applications.
This
review
provides
an
overview
cancer
theranostics
based
on
coated
peptides,
ligands,
targeting
