Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Lanthanide‐based
luminescence
nanothermometry
has
demonstrated
unprecedented
advantages
in
the
development
of
nanotheranostic
platforms
for
potential
medical
applications,
yet
despite
exponential
research
progress
and
great
enthusiasm
across
various
related
disciplines,
a
swift
bench‐to‐bedside
translation
seems
to
be
still
out
reach.
This
is
predominantly
fundamental
issues
at
preclinical
stage,
such
as
complex
nanomaterials
design,
incomplete
optimization,
fragmented
characterization,
insufficient
validation
nanothermometer
performance
physiological
environments.
The
main
impediments
currently
are
important
biophysicochemical
that
must
addressed
comprehensively,
first
foremost
available
vitro
systems,
before
going
on
vivo
investigations.
review
outlines
critical
perspective,
well
route
suggestions
underexplored
aspects
address
significantly
minimize
existing
translational
gap.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(43), С. 58920 - 58930
Опубликована: Окт. 17, 2024
Nanothermometers
can
detect
changes
in
the
local
temperature
living
cells
and
vivo,
revealing
fundamental
biological
properties.
Despite
exploration
of
different
temperature-responsive
materials,
design
development
temperature-sensing
probes
with
high
brightness
sensitivity
remain
a
daunting
challenge.
Here,
we
employed
UiO-66
type
metal-organic
frameworks
(MOFs)
to
anchor
UNCPs
on
surface
MOFs
for
constructing
MOF@UCNPs
nanohybrids.
The
situ
composite
method
leads
coordination
interaction
between
ligands
UCNPs,
enabling
controlled
formation
UCNPs.
Remarkably,
favors
anomalous
thermo-enhanced
luminescence,
achieving
35-fold
enhancement
UiO-66@NaYF4:Yb/Tm
at
413
K.
Furthermore,
these
nanohybrids
luminescence
are
developed
as
multifunctional
bioimaging
intracellular
sensing,
demonstrating
thermal
1.92%
K-1
physiological
range.
Based
findings,
monitoring
position
was
successfully
carried
out
by
designed
nanoprobes
vivo.
These
findings
underscore
potential
nanohybrids,
opening
up
new
avenues
platform
analysis.
The
composites
fabricated
by
lanthanide-doped
upconversion
nanomaterials
(UCNMs)
and
metal-organic
frameworks
(MOFs)
possess
the
merits
of
both
parent
materials,
exhibiting
great
potential
for
bioapplications.
This
chapter
provides
an
overview
recent
advances
in
UCNM-MOF
composites,
with
emphasis
on
fabrication
bioapplications
newly
developed
composites.
According
to
configuration
reported
strategies
fabricating
are
divided
into
three
types:
situ
encapsulation,
partial
embedment,
interfacial
attachment.
process,
mechanisms,
merits,
limitations
these
discussed.
Bioapplications
including
therapy,
bioimaging,
biosensing,
then
illustrated
selected
examples.
also
some
perspectives
future
development
Developing
effective
radiotherapy
is
impeded
by
tumor
radioresistance,
imprecise
treatment,
and
the
need
for
accurate
imaging.
Herein,
a
multifunctional
gadolinium-based
nanoprobe
(GBD)
presented,
integrating
bioorthogonal
click
chemistry
theranostics
to
enhance
retention,
magnetic
resonance
imaging
(MRI)
contrast,
radiosensitivity.
GBD
synthesis
involved
biomimetic
mineralization
of
bovine
serum
albumin
(BSA)
with
gadolinium
ions
form
nanoparticles
(GB),
followed
conjugation
dibenzocyclooctyne
(DBCO).
The
optimized
exhibited
an
elevated
longitudinal
relaxivity
(r1)
25.54
mM-1
s-1,
which
represented
6.7-fold
enhancement
compared
clinical
MRI
contrast
agent
magnevist
(Gd-DTPA,
3.81
s-1).
Notably,
application
enhanced
affinity
retention
within
cells
modified
express
azide
as
artificial
receptor.
This
novel
strategy
up
16
days
postinjection,
outperforming
DBCO-modified
small
molecule
(Gd-DBCO)
less
than
1-day
retention.
Such
prolonged
facilitated
continuous
radiosensitization
throughout
course,
negating
multiple
injections,
substantially
boosted
effectiveness
radiotherapy.
study
demonstrates
transformative
potential
combining
nanotechnology
in
radiotherapy,
offering
precise
targeting
platform,
real-time
monitoring,
improved
treatment
outcomes.
Advanced NanoBiomed Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Lanthanide‐based
luminescence
nanothermometry
has
demonstrated
unprecedented
advantages
in
the
development
of
nanotheranostic
platforms
for
potential
medical
applications,
yet
despite
exponential
research
progress
and
great
enthusiasm
across
various
related
disciplines,
a
swift
bench‐to‐bedside
translation
seems
to
be
still
out
reach.
This
is
predominantly
fundamental
issues
at
preclinical
stage,
such
as
complex
nanomaterials
design,
incomplete
optimization,
fragmented
characterization,
insufficient
validation
nanothermometer
performance
physiological
environments.
The
main
impediments
currently
are
important
biophysicochemical
that
must
addressed
comprehensively,
first
foremost
available
vitro
systems,
before
going
on
vivo
investigations.
review
outlines
critical
perspective,
well
route
suggestions
underexplored
aspects
address
significantly
minimize
existing
translational
gap.
