Matching the kinetics of natural enzymes with a single-atom iron nanozyme

Nature Catalysis, Год журнала: 2021, Номер 4(5), С. 407 - 417

Опубликована: Май 6, 2021

Язык: Английский

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Nanozymes Inspired by Natural Enzymes

Accounts of Materials Research, Год журнала: 2021, Номер 2(7), С. 534 - 547

Опубликована: Июнь 24, 2021

ConspectusNanozymes, nanomaterials with enzyme-like activities high structural stability, adjustable catalytic activity, functional diversity, recyclability, and feasibility in large-scale preparation, have become a hot spot the field of artificial enzymes recent years are expected to potential surrogates competitors for natural practical applications. With development in-depth research wide range application requirements, creating nanozymes performance comparable or even surpassing that has been key topic this field. Most reported past were obtained based on random synthesis screening, which efficiency is far inferior enzymes. Natural evolved over hundreds millions developed lot high-efficiency catalysis know-how hidden their features. To create highly active nanozymes, we assumed there general structure–activity relationship between proposed nanozyme optimization strategy by grafting principles into rational design nanozymes. On basis bioinspired strategy, series exhibit similar closer beyond those successfully synthesized. By now, rationally designed high-activity current nanozymes.In Account, focus representative progress systemic construction devoted introducing strategic concepts We show de novo simulating amino acid microenvironment using metal-free architecture coordination structure metal sites an effective significantly improving A future perspective challenges countermeasures these achievements. hope biologically inspired perception will arouse widespread interest fundamental applications as well provide inspiration

Язык: Английский

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GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Advanced Materials, Год журнала: 2020, Номер 32(42)

Опубликована: Сен. 11, 2020

Abstract Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity nanozymes in tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria‐like PEG/Ce‐Bi@DMSN nanozyme developed by coating uniform Bi 2 S 3 nanorods (NRs) with dendritic mesoporous silica (Bi @DMSN) then decorating ultrasmall ceria into large mesopores @DMSN. The exhibit dual enzyme‐mimic activities (peroxidase‐mimic catalase‐mimic) under acidic conditions that can regulate TME, is, simultaneously elevate oxidative stress relieve hypoxia. In addition, effectively consume overexpressed glutathione (GSH) through redox reaction. Photothermal therapy (PTT) introduced to synergistically improve enzyme‐mimicking depletion GSH tumors photonic hyperthermia. This achieved taking advantage desirable light absorbance second near‐infrared (NIR‐II) window nanozymes. Subsequently reactive oxygen species (ROS)‐mediated efficiency significantly improved. Therefore, this study provides proof concept hyperthermia‐augmented multi‐enzymatic ablation.

Язык: Английский

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A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nano-Micro Letters, Год журнала: 2021, Номер 13(1)

Опубликована: Июль 9, 2021

Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress nanozymes has been made with deep investigation of diverse and rapid development related nanotechnologies. As promising alternatives for natural enzymes, have broadened way toward clinical medicine, food safety, environmental monitoring, chemical production. The past decade witnessed metal- metal oxide-based owing their remarkable physicochemical properties parallel low cost, high stability, easy storage. It is widely known that study catalytic activities mechanism sheds significant influence on applications nanozymes. This review digs into characteristics intrinsic nanozymes, especially emphasizing recent biological analysis, relieving inflammation, antibacterial, cancer therapy. We also conclude present challenges provide insights future constituted oxide nanomaterials.

Язык: Английский

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Metal–Organic Framework Derived Nanozymes in Biomedicine

Accounts of Chemical Research, Год журнала: 2020, Номер 53(7), С. 1389 - 1400

Опубликована: Июнь 29, 2020

ConspectusNanozymes, which integrate the advantages of both nanomaterials and natural enzymes, have accumulated enormous research interest over past decades because opportunity they provide to appreciate further cultivate artificial enzymes with comparable properties. By mimicking coordination environments catalytic sites in nanozymes confined nanostructures can serve as substitutes many processes activity robust stability even harsh conditions. Since pioneering report about peroxidase-mimicking ferromagnetic nanoparticles 2007, been developed specialized for intrinsic enzyme-mimicking property. With rapid development nanoscience nanotechnology, superior advantages, such large-scale production, desired activity, stability, bridge nanozymes.Metal–organic frameworks (MOFs) their derivatives hold great promise direct surrogates conventional enzymatic reactions. According chemical nature, MOF-based be divided into three main categories: pristine MOFs, enzyme-encapsulated MOF composites, derivatives. Due versatility metallic nodes bridging linkers together feasibility postsynthetic engineering modification, MOFs are envisioned one most appropriate this purpose. Using precursors or sacrificial templates, multiple including carbon-based (e.g., heteroatom-doped carbon M–N–C moiety), metal oxide/carbon nanoparticles, metal/carbon rationally synthesized through one-step carbonization/oxidation indirect post-synthesis treatments linker-exchange node-doping). Compared existing nanozymes, open up a new avenue constructing mesoporous nanozymes. In way, properties still maintained, while greatly improved. Account, we highlight some important advances (including moieties (M = single atom), oxide/carbon, metal/carbon, obtained linker exchange doping strategies) activity. We also demonstrate that, integrating physicochemical activities MOF-derived multifunctional platforms biomedical fields antibacterial agents, biosensors, imaging, cancer therapy, environmental protection. Finally, propose future design principles possible approaches deeper understanding mechanisms, thus pointing out directions offer more opportunities enzyme-engineering industry.

Язык: Английский

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Stimuli‐Responsive Manganese Single‐Atom Nanozyme for Tumor Therapy via Integrated Cascade Reactions

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(17), С. 9480 - 9488

Опубликована: Фев. 6, 2021

Abstract The single‐atom enzyme (SAE) is a novel type of nanozyme that exhibits extraordinary catalytic activity. Here, we constructed PEGylated manganese‐based SAE (Mn/PSAE) by coordination manganese to nitrogen atoms in hollow zeolitic imidazolate frameworks. Mn/PSAE catalyzes the conversion cellular H 2 O . OH through Fenton‐like reaction; it also promotes decomposition and continuously cytotoxic − via oxidase‐like activity more pronounced weak acidic tumor environment; therefore, these cascade reactions enable sufficient generation reactive oxygen species (ROS) effectively kill cells. prominent photothermal property amorphous carbon can be utilized for therapy. Hence, significant therapeutic efficacy microenvironment stimulated multiple ROS

Язык: Английский

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Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Advanced Materials, Год журнала: 2020, Номер 33(4)

Опубликована: Дек. 2, 2020

Abstract The past decades have witnessed hyperthermia therapy (HTT) as an emerging strategy against malignant tumors. Nanomaterial‐based photothermal (PTT) and magnetic (MHT), highly effective noninvasive treatment models, offer advantages over other strategies in the of different types However, both PTT MHT cannot completely cure cancer due to recurrence distal metastasis. In recent years, immunotherapy has attracted widespread attention owing its capability activate body's own natural defense identify, attack, eradicate cells. Significant efforts been devoted studying activated immune responses caused by hyperthermia‐ablated this article, synergistic mechanism HTT immunotherapy, including immunogenic cell death reversal immunosuppressive tumor microenvironment is discussed. reports combination or HTT‐based multimodal with immunoadjuvant exploitation, checkpoint blockade therapy, adoptive cellular are summarized. As highlighted, these could achieve synergistically enhanced therapeutic outcomes primary tumors metastatic lesions, prevent recurrence, prolong survival period. Finally, current challenges prospective developments HTT‐synergized also reviewed.

Язык: Английский

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Nanozymes: Definition, Activity, and Mechanisms

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 17, 2023

Abstract “Nanozyme” is used to describe various catalysts from immobilized inorganic metal complexes, enzymes nanoparticles. Here, the history of nanozymes dvescribed in detail, and they can be largely separated into two types. Type 1 refer or on nanomaterials, which were dominant first decade since 2004. 2 nanozymes, rely surface catalytic properties are dominating type past decade. The definition evolving, a based same substrates products as able cover most currently claimed although may have different mechanisms compared their enzyme counterparts. A broader inspire application‐based research replace with nanomaterials for analytical, environmental, biomedical applications. Comparison also requires clear nanozyme unit. Four ways defining unit described, iron oxide horseradish peroxidase activity comparison examples each definition. Growing work devoted understanding mechanism provides basis further rational engineering active sites. Finally, future perspective field discussed.

Язык: Английский

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Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Янв. 11, 2023

Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest due to their ability scavenge anion, the origin of most reactive oxygen species in vivo. However, SOD nanozymes reported thus far yet approach natural enzymes. Here, we report a carbon dot (C-dot) nanozyme catalytic over 10,000 U/mg, comparable that Through selected chemical modifications and theoretical calculations, show SOD-like C-dots relies on hydroxyl carboxyl groups for binding anions carbonyl conjugated π-system electron transfer. Moreover, C-dot exhibit intrinsic targeting oxidation-damaged cells effectively protect neuron ischemic stroke male mice model. Together, our study sheds light structure-activity relationship nanozymes, demonstrates potential treating oxidation stress related diseases.

Язык: Английский

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Recent Advances in Nanozymes: From Matters to Bioapplications

Advanced Functional Materials, Год журнала: 2021, Номер 32(14)

Опубликована: Дек. 16, 2021

Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute

Язык: Английский

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