Lack of selectivity in sample preparation ‒ An achilles heel of compound-specific isotope analysis for environmental micropollutants
TrAC Trends in Analytical Chemistry,
Год журнала:
2024,
Номер
180, С. 117908 - 117908
Опубликована: Авг. 12, 2024
The
role
of
compound-specific
isotope
analysis
(CSIA)
in
environmental
research
has
been
proven
over
the
last
few
decades.
Despite
advances
analytical
methods
and
instrumentation,
applying
CSIA
to
low-concentration
contaminants,
especially
at
field
scale,
remains
limited.
In
this
perspective
paper,
we
argue
that
limitation
stems
from
underdeveloped
sample
preparation
techniques,
particularly
lack
required
selectivity.
Drawing
an
extensive
review
nearly
600
studies
on
(i)
analyze
methodologies'
distribution
dedication
studies,
discussing
their
connection
with
maturity
suitable
techniques.
Additionally,
(ii)
examine
general
trends
sorbent
phase
technologies,
assessing
adequacy
meet
CSIA's
targeted
nature
applicability
micropollutants.
advocating
for
a
paradigm
shift,
(iii)
emphasize
need
adapt
future
development
strategies
light
past
current
innovations.
Язык: Английский
Quartz Crystal Microbalance as a Holistic Detector for Quantifying Complex Organic Matrices during Liquid Chromatography: 1. Coupling, Characterization, and Validation
Analytical Chemistry,
Год журнала:
2024,
Номер
96(19), С. 7429 - 7435
Опубликована: Апрель 29, 2024
A
matrix
in
highly
complex
samples
can
cause
adverse
effects
on
the
trace
analysis
of
targeted
organic
compounds.
suitable
separation
target
analyte(s)
and
before
instrumental
is
often
a
vital
step
for
which
chromatographic
cleanup
methods
remain
one
most
frequently
used
strategies,
particularly
high-performance
liquid
chromatography
(HPLC).
The
lack
simple
real-time
detection
technique
that
quantify
entirety
during
this
step,
especially
with
gradient
solvents,
renders
optimization
challenging.
This
paper,
along
companion
one,
explores
possibilities
limitations
quartz
crystal
microbalance
(QCM)
dry-mass
sensing
quantifying
matrices
HPLC.
To
end,
work
coupled
QCM
microfluidic
spray
dryer
commercial
HPLC
system
using
flow
splitter
developed
calibration
data
processing
strategy.
was
characterized
terms
quantification
limits,
LOD
=
4.3–15
mg/L
LOQ
16–52
mg/L,
respectively,
different
eluent
compositions.
Validation
natural
matter
an
environmental
sample
against
offline
total
carbon
confirmed
approach's
feasibility,
absolute
recovery
103
±
10%.
Our
findings
suggest
could
serve
as
valuable
tool
analysts
routinely
employing
methods,
offering
potential
benefits
across
various
analytical
fields.
Язык: Английский
Nitrogen stable isotope analysis of sulfonamides by derivatization-gas chromatography-isotope ratio mass spectrometry
Qingyuan Dou,
Aoife Canavan,
Yuhao Fu
и другие.
Analytical and Bioanalytical Chemistry,
Год журнала:
2024,
Номер
416(19), С. 4237 - 4247
Опубликована: Июнь 7, 2024
Abstract
The
continuous
introduction
of
micropollutants
into
the
environment
through
livestock
farming,
agricultural
practices,
and
wastewater
treatment
is
a
major
concern.
Among
these
pollutants
are
synthetic
sulfonamide
antibiotics
such
as
sulfamethoxazole,
which
not
always
fully
degraded
pose
risk
fostering
antimicrobial
resistance.
It
challenging
to
assess
degradation
sulfonamides
with
conventional
concentration
measurements.
This
study
introduces
compound-specific
isotope
analysis
nitrogen
ratios
at
natural
abundances
by
derivatization-gas
chromatography
hyphenated
ratio
mass
spectrometry
(derivatization-GC-IRMS)
new
more
precise
method
for
tracing
origin
sulfonamides.
Here,
sulfamethoxazole
was
used
model
compound
develop
optimize
derivatization
conditions
using
(trimethylsilyl)diazomethane
reagent.
With
optimized
conditions,
accurate
reproducible
δ
15
N
derivatization-GC-IRMS
achieved
in
two
different
laboratories
limit
3
nmol
on
column,
corresponding
0.253
µg
non-derivatized
SMX.
Application
four
further
sulfonamides,
sulfadiazine,
sulfadimethoxine,
sulfadimidine,
sulfathiazole,
shows
versatility
developed
method.
Its
benefit
demonstrated
first
application,
highlighting
possibility
distinguishing
from
suppliers
pharmaceutical
products.
Graphical
Язык: Английский