Tailored Metal‐Organic Framework‐Based Nanozymes for Enhanced Enzyme‐Like Catalysis

Angewandte Chemie International Edition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

Abstract The global crisis of bacterial infections is exacerbated by the escalating threat microbial antibiotic resistance. Nanozymes promise to provide ingenious solutions. Here, we reported a homogeneous catalytic structure Pt nanoclusters with finely tuned metal–organic framework (ZIF‐8) channel structures for treatment infected wounds. Catalytic site normalization showed that active aggregates fine‐tuned pore modifications had capacity 14.903×10 5 min −1 , which was 18.7 times higher than particles in monodisperse state ZIF‐8 (0.793×10 ). In situ tests revealed change from homocleavage heterocleavage hydrogen peroxide at interface nanozyme one key reasons improvement activity. Density‐functional theory and kinetic simulations reaction jointly determine role center substrate together. Metabolomics analysis developed nanozyme, working conjunction reactive oxygen species, could effectively block energy metabolic pathways within bacteria, leading spontaneous apoptosis rupture. This pioneering study elucidates new ideas regulation artificial enzyme activity provides perspectives development efficient substitutes.

Язык: Английский

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Miniature dual-channel electrochemical 3D-printed sensing platform for enzyme-free screening of L-lactic acid in foodstuffs accompanying pH recognition

Food Chemistry, Год журнала: 2024, Номер 465, С. 142188 - 142188

Опубликована: Ноя. 21, 2024

Язык: Английский

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Advances in Biosensor Technologies for Infectious Diseases Detection

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 117979 - 117979

Опубликована: Сен. 1, 2024

Язык: Английский

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Electrochemical Immunosensor based on NiO for CA 15-3 detection and Agent-Based Modelling for Treatment Optimization

Electrochimica Acta, Год журнала: 2025, Номер unknown, С. 145708 - 145708

Опубликована: Янв. 1, 2025

Язык: Английский

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Carboxylate-Terminated Electrode Surfaces Improve the Performance of Electrochemical Aptamer-Based Sensors

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Electrochemical aptamer-based (EAB) sensors are a molecular measurement platform that enables the continuous, real-time of wide range drugs and biomarkers in situ living body. EAB fabricated by depositing thiol-modified, target-binding aptamer on surface gold electrode, followed backfilling with an alkanethiol to form self-assembled monolayer. And while majority previously described have employed hydroxyl-terminated monolayers, handful studies shown altering monolayer headgroup can strongly affect sensor performance. Here, using 4 different sensors, we show mixed monolayers composed mixtures 6-carbon thiols varying amounts either 6- or 8-carbon, carboxylate-terminated lead improved Specifically, use such enhances signal gain (the relative change seen upon target addition) for all tested often several fold, both buffer whole blood at room temperature physiological temperatures. Moreover, these improvements achieved without significant changes affinity stability resulting sensors. In addition proving ready means improving performance, results suggest exploration chemistry electrode could prove be fruitful advancing this unique vivo sensing technology.

Язык: Английский

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Multifunctional dopamine-modified conjugated polymer nanoparticles for ultrasensitive immunoassays

Talanta, Год журнала: 2025, Номер 288, С. 127715 - 127715

Опубликована: Фев. 11, 2025

Язык: Английский

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Harnessing bifunctional nanozyme with potent catalytic and signal amplification for innovating electrochemical immunoassay

Biosensors and Bioelectronics, Год журнала: 2025, Номер unknown, С. 117340 - 117340

Опубликована: Март 1, 2025

Язык: Английский

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Enhanced photocurrents for photoelectrochemical immunoassay of alpha-fetoprotein with Pt-functionalized Bi2O2S nanoflowers

Analytica Chimica Acta, Год журнала: 2024, Номер 1330, С. 343281 - 343281

Опубликована: Сен. 27, 2024

Язык: Английский

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Recent advances and analytical perspectives in MXene-based electrochemical miniaturized sensors for environmental analysis and monitoring

Microchemical Journal, Год журнала: 2024, Номер 206, С. 111433 - 111433

Опубликована: Авг. 14, 2024

Язык: Английский

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Copper ions coordination-promoted self-assembly of DNA nanoflowers as cascade catalytic nanoreactor for colorimetric biosensor

Talanta, Год журнала: 2024, Номер 282, С. 127049 - 127049

Опубликована: Окт. 15, 2024

Язык: Английский

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