Polycarbonate-Based Polymersome Photosensitizers with Cell-Penetrating Properties for Improved Killing of Cancer Cells

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Polymer-based photosensitizers have found various applications in photodynamic therapy (PDT). However, the absence of targeting ability commonly results a substantial reduction photosensitizer accumulation at tumor site, significantly limiting therapeutic efficacy system. In addition, development biodegradable polymeric is critical importance for biological applications. this work, we present guanidine-functionalized based on poly(trimethylene carbonate) (PTMC) block copolymers, which can self-assemble into polymersomes. The presence guanidine groups surface polymersomes enhance cellular uptake efficiency photosensitizers, thereby improving intracellular production reactive oxygen species (ROS). vitro study demonstrates that guanidinylated polymersome promote killing cancer cells compared to unfunctionalized light irradiation. PTMC-based with integration cell-targeting and biodegradability, are anticipated provide novel strategy developing advanced biomedical polymer systems PDT.

Язык: Английский

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A "Building-Block" Strategy for Porphyrin-Based Two-Photon Photosensitizers Dual-Targeting Cancer Cells and Subcellular Organelles

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112759 - 112759

Опубликована: Март 1, 2025

Язык: Английский

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Nanoparticles for Photodynamic Therapy of Breast Cancer: A Review of Recent Studies

Molecules, Год журнала: 2025, Номер 30(7), С. 1571 - 1571

Опубликована: Март 31, 2025

Photodynamic therapy (PDT) is a therapeutic method based on the interaction between light and photosensitizer. Supported by nanoparticles, this represents promising interdisciplinary approach for treatment of many diseases. This article reviews latest 2024 developments in design applications nanoparticles dedicated to stand-alone PDT breast cancer. Strategies improve efficacy enhancing reactive oxygen species (ROS) production, precise delivery photosensitizers their stabilization systemic circulation are discussed, among others. Results from preclinical studies indicate significant improvements efficacy, including inhibition tumor growth, reduction metastasis improvement immune microenvironment. The potential these technologies expand medicine need further clinical trials confirm safety highlighted.

Язык: Английский

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Self-assembled nanoprobes for cancer phototheranostics

Coordination Chemistry Reviews, Год журнала: 2025, Номер 538, С. 216643 - 216643

Опубликована: Апрель 18, 2025

Язык: Английский

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Advances in upconversion nanomaterials for tumor phototherapy

Materials Today Communications, Год журнала: 2024, Номер 41, С. 110301 - 110301

Опубликована: Сен. 4, 2024

Язык: Английский

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