Outstanding Advantages, Current Drawbacks, and Significant Recent Developments in Mechanochemistry: A Perspective View

Crystals, Год журнала: 2023, Номер 13(1), С. 124 - 124

Опубликована: Янв. 10, 2023

Although known since antiquity, mechanochemistry has remained dormant for centuries. Nowadays, is a flourishing research field at the simultaneous stages of gathering data and (often astonishing) observations, scientific argumentation toward their analysis, which combination interdisciplinary expertise necessary. Mechanochemistry’s implementation as synthetic method constantly increasing, although it remains far from being fully exploited, or understood on basis fundamental principles. This review starts by describing many remarkable advantages mechanochemical reactions, simplifying “greening” chemistry in solutions. description followed an overview current main weaknesses to be addressed near future systematic study its energetics chemical mechanisms. finishes recent breakthrough experimental advances, such situ kinetics monitoring using synchrotron X-ray powder diffraction Raman spectroscopy, plus equally significant computational approaches, quantum mechanochemistry, used understanding covalent hydrogen bond ruptures biomolecules mechanophores polymers single-molecule level. Combined with new technologies control temperature pressure ball mills, these appealing methods are promising tools establishing knowledge necessary reactivity

Язык: Английский

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Salient Achievements in Synthetic Organic Chemistry Enabled by Mechanochemical Activation

Synthesis, Год журнала: 2023, Номер 55(16), С. 2439 - 2459

Опубликована: Май 3, 2023

Abstract Although known for millennia, it is only recently that mechanochemistry has received serious attention by chemists. Indeed, during the past 15 years an extraordinary number of reports concerning solid-state chemical transformations through grinding and milling techniques have been recorded. This short review discusses circumstances led this renaissance, highlighting present intense interest in so-called green chemistry, enabling capacity to handle insoluble substrates, identification profound influence additives can on mechanochemically activated reactions. The core account focuses salient developments synthetic organic especially amino acid peptide­ mechanosynthesis, successful employment mechanochemical activation combination with asymmetric organocatalysis, promising enzymatic whole cell biocatalysis, remarkable achievement multicomponent selective reactions via complex, multistep reaction pathways, mechanosynthesis representative heterocycles. final section comments some pending tasks area, such as scaling-up processes be practical use industry, requirement easier more efficient control parameters monitoring devices, consequently careful analysis additional procedures a proper understanding phenomena. 1 Introduction 2 Brief History Mechanochemistry 3 Milling Equipment Reaction Parameters 4 Attributes That Propelled Its Present Renaissance 4.1 Enormous Attention Being Presently Paid Sustainable Chemistry 4.2 Reduced Energy Consumption 4.3 Additive-Based 4.4 Handling Insoluble Reactants 4.5 ‘Impossible’ Reactions Are Successful 4.6 Air- Water-Sensitive Reagents Ball 5 Salient Developments Mechanochemical Activation Synthetic Organic 5.1 Amino Acid Peptide Mechanosynthesis 5.2 Asymmetric Synthesis Organocatalysis under Ball-Milling Conditions 5.3 Mechanoenzymology 5.4 Multicomponent Activated 5.5 Heterocycles Modification 6 Future Directions 6.1 Scaling-Up Protocols 6.2 Temperature-Controlled 6.3 Understanding Transformations 6.4 Emerging Techniques 7 Conclusions

Язык: Английский

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Tinkering with Mechanochemical Tools for Scale Up

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(44)

Опубликована: Апрель 28, 2023

Mechanochemistry provides an environmentally benign platform to develop more sustainable chemical processes by limiting raw materials, energy use, and waste generation while using physically smaller equipment. A continuously growing research community has steadily showcased examples of beneficial mechanochemistry applications at both the laboratory preparative scale. In contrast solution-based chemistry, mechanochemical have not yet been standardized, thus scaling up is still a nascent discipline. The purpose this Minireview highlight similarities, differences challenges various approaches that successfully applied for range scales. We hope provide discussion starting point those interested in further developing commercial use and/or industrialisation.

Язык: Английский

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Intermediates in Mechanochemical Reactions

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(14)

Опубликована: Янв. 5, 2024

Abstract Mechanochemical reactions offer methodological and environmental advantages for chemical synthesis, constantly attracting attention within the scientific community. Besides unmistakable sustainability advantages, conditions under which mechanochemical occur, namely solventless conditions, sometimes facilitate isolation of otherwise labile or inaccessible products. Despite these limited knowledge exists regarding mechanisms types intermediates involved. Nevertheless, in an expanding number cases, ex situ monitoring techniques have allowed observation, characterization, reaction transformations. In this Minireview, we present a series examples reactive been detected spanning organic, organometallic, inorganic, materials chemistry. Many were stabilized by non‐covalent interactions, played pivotal role guiding We believe that uncovering understanding such instances, growing mechanochemistry community could find novel opportunities catalysis discover new while achieving simplification design.

Язык: Английский

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Leveraging mechanochemistry for sustainable polymer degradation

Polymer Journal, Год журнала: 2024, Номер 56(4), С. 249 - 268

Опубликована: Янв. 12, 2024

Abstract Over 8 billion tons of plastic have been produced to date, and a 100% reclamation recycling strategy is not foreseeable. This review summarizes how the mechanochemistry polymers may contribute sustainable polymer future by controlling degradation only de novo developed designer but also plastics in existing waste streams. The historical development presented while highlighting current examples mechanochemically induced degradation. Additionally, theoretical computational frameworks are discussed that lead discovery better understanding new mechanochemical reactions future. takes into account technical engineering perspectives converging fields trituration with particular focus on fate commodity potential technologies monitor they occur. Therefore, unique perspective multiple communities presented, need for transdisciplinary research tackle high-leverage parameters governing an eventually successful approach circular economy.

Язык: Английский

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Crystal engineering: from promise to delivery

Chemical Communications, Год журнала: 2023, Номер 59(95), С. 14052 - 14062

Опубликована: Янв. 1, 2023

Twenty years ago, I wrote a Chem. Commun. feature article entitled “ Crystal Engineering: where from? Where to? ”: an update is in order.

Язык: Английский

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Mechanophotocatalysis: A Generalizable Approach to Solvent‐minimized Photocatalytic Reactions for Organic Synthesis

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(13)

Опубликована: Янв. 24, 2024

This proof-of-concept study cements the viability and generality of mechanophotocatalysis, merging mechanochemistry photocatalysis to enable solvent-minimized photocatalytic reactions. We demonstrate transmutation four archetypal solution-state reactions a environment driven by combined actions milling, light, photocatalysts. The chlorosulfonylation alkenes pinacol coupling aldehydes ketones were conducted under solvent-free conditions with competitive or superior efficiencies their analogues. Furthermore, decarboxylative alkylations are shown function efficiently conditions, while photoinduced energy transfer promoted [2+2] cycloaddition chalcone experiences significant initial rate enhancement over its variant. work serves as platform for future discoveries in an underexplored field: validating that is not only generalizable photocatalysis, but can also offer valuable advantages.

Язык: Английский

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Mechanochemistry for Organic and Inorganic Synthesis

ACS Organic & Inorganic Au, Год журнала: 2024, Номер 4(5), С. 432 - 470

Опубликована: Авг. 7, 2024

In recent years, mechanochemistry has become an innovative and sustainable alternative to traditional solvent-based synthesis. Mechanochemistry rapidly expanded across a wide range of chemistry fields, including diverse organic compounds active pharmaceutical ingredients, coordination compounds, organometallic complexes, main group frameworks, technologically relevant materials. This Review aims highlight advancements accomplishments in mechanochemistry, underscoring its potential as viable eco-friendly conventional solution-based methods the field synthetic chemistry.

Язык: Английский

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Resonant acoustic mixing (RAM) for efficient mechanoredox catalysis without grinding or impact media

Chemical Communications, Год журнала: 2022, Номер 59(8), С. 1010 - 1013

Опубликована: Дек. 12, 2022

Resonant acoustic mixing (RAM) enables mechanoredox catalysis with BaTiO3 as the piezoelectric catalyst on model diazonium coupling reactions. RAM proceeds without formal grinding or impact media, is faster than analogous ball-milling strategy, and readily scalable. X-ray diffraction spectroscopy indicate that reusability of a under might be limited by boration.

Язык: Английский

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Green Synthesis of Reticular Materials

Advanced Functional Materials, Год журнала: 2023, Номер 34(43)

Опубликована: Сен. 1, 2023

Abstract To help ensure a prosperous future on Earth for coming generations, academia and industry need to transform the way they plan carry out synthesis of novel materials make them more environmentally sustainable. In particular, field reticular materials, i.e., metal‐organic frameworks, zeolitic imidazolate covalent organic has great potential outperform other revolutionize various fields applications. This review highlights several key aspects from choice their starting solvents synthetic methodologies that fall under umbrella Green Chemistry principles, incorporates Circular Economy perspective by providing relevant strategies such as reuse, regeneration, or recycling maximize value Earth's available resources. Moreover, it will shed light life cycle assessment results selected consider how constraints imposed metrics, circular patterns shape rational sustainable design discovery materials.

Язык: Английский

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