Triple circularly polarized luminescence of phenylalanine-based supramolecular gels regulated by kinetic and thermodynamic assembly pathways

Chemical Communications, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Under kinetic and thermodynamic pathway control, a single phenylalanine-based gelator self-assembles into various chiral nanostructures with multiple circularly polarized luminescence.

Язык: Английский

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Programmable Coacervate Droplets via Reaction-Coupled Liquid–Liquid Phase Separation (LLPS) and Competitive Inhibition

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Membraneless biomolecular condensates formed by liquid–liquid phase separation (LLPS) are crucial for many spatiotemporal biological functions. Designing synthetic mimics to emulate and understand LLPS is an active area of research, which has led the development coacervate droplets through elegant bioinspired designs. However, recent interest in this field shifted toward designing programmable coacervates impart control over these liquid phases. Herein, we demonstrate programming systems employing concepts competitive binding reaction-coupled assembly involving dynamic covalent bonds. Our results utilize small building blocks that follow a simple coacervation mechanism, distinguishing approach from previously reported complex coacervates, often rely on reaction-controlled generation one components. We introduce using bonds (boronate esters) chromophoric appended with terminal boronic acid groups. Upon reaction substrates (monosaccharides), form molecular structures resembling "sticker-and-spacer" designs coacervation, leading reaction-driven, temporally controlled process. The differential reactivity various monosaccharides, combined reversibility bonds, enables binding-driven growth, inhibition, dissolution process, offering new strategies reminiscent protein-induced inhibition condensates. Detailed spectroscopic probing kinetic analyses provide mechanistic insights into autocatalytic growth processes, revealing glucose-selective nature system. Finally, coupling reactions temporal pH modulation transient can be visualized confocal microscopy. anticipate will pave way novel biorelevant emergent properties.

Язык: Английский

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Bioinspired programmable coacervate droplets and self-assembled fibers through pH regulation of monomers

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Demonstration of transient coacervate droplets and programmable fibers was achieved by temporally regulating the pH solution through biocatalytic modulation.

Язык: Английский

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Organic two-dimensional nanostructures: Harnessing soft matter for multifunctional applications

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126506 - 126506

Опубликована: Ноя. 1, 2024

Язык: Английский

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