Journal of the American Chemical Society,
Год журнала:
2022,
Номер
144(15), С. 6907 - 6917
Опубликована: Апрель 7, 2022
Enzyme-regulated
in
situ
self-assembly
of
peptides
represents
one
versatile
strategy
the
creation
theranostic
agents,
which,
however,
is
limited
by
strong
dependence
on
enzyme
overexpression.
Herein,
we
reported
self-amplifying
assembly
precisely
macrophages
associated
with
expression
for
improving
anti-inflammatory
efficacy
conventional
drugs.
The
assembling
system
was
created
via
coassembling
an
enzyme-responsive
peptide
its
derivative
functionalized
a
protein
ligand.
Reduction
NAD(P)H
quinone
dehydrogenase
1
(NQO1)
led
to
formation
nanofibers
high
affinity
protein,
thereby
facilitating
NQO1
expression.
improved
level
conversely
promoted
into
nanofibers,
thus
establishing
amplifying
relationship
between
and
macrophages.
Utilization
as
vehicles
drug
dexamethasone
allowed
passive
targeting
delivery
acute
injured
lungs.
Both
vitro
vivo
studies
confirmed
capability
enhance
simultaneous
alleviation
reactive
oxygen
species
side
effect
downregulation
proinflammatory
cytokines.
Our
findings
demonstrate
manipulation
living
cells
regular
self-amplification
process,
providing
unique
supramolecular
agents
cells.
Chemical Reviews,
Год журнала:
2022,
Номер
122(16), С. 13235 - 13400
Опубликована: Авг. 2, 2022
It
is
not
a
coincidence
that
both
chirality
and
noncovalent
interactions
are
ubiquitous
in
nature
synthetic
molecular
systems.
Noncovalent
interactivity
between
chiral
molecules
underlies
enantioselective
recognition
as
fundamental
phenomenon
regulating
life
human
activities.
Thus,
represent
the
narrative
thread
of
fascinating
story
which
goes
across
several
disciplines
medical,
chemical,
physical,
biological,
other
natural
sciences.
This
review
has
been
conceived
with
awareness
modern
attitude
toward
its
consequences
needs
to
be
founded
on
multidisciplinary
approaches
disclose
basis
essential
phenomena
domain
With
primary
aim
discussing
this
topic
an
integrated
way,
comprehensive
pool
rational
systematic
information
provided,
concerns
fundamentals
chirality,
description
interactions,
their
implications
processes
occurring
different
contexts.
A
specific
focus
devoted
enantioselection
chromatography
electromigration
techniques
because
unique
feature
"multistep"
processes.
second
motivation
for
writing
make
clear
statement
about
state
art,
tools
we
have
at
our
disposal,
what
still
missing
fully
understand
mechanisms
underlying
recognition.
Chemical Society Reviews,
Год журнала:
2021,
Номер
50(13), С. 7436 - 7495
Опубликована: Янв. 1, 2021
Compounds
with
a
nitrobenzoxadiazole
(NBD)
skeleton
exhibit
high
reactivity
toward
biological
nucleophilies
accompanied
by
distinct
colorimetric
and
fluorescent
changes,
environmental
sensitivity,
small
size,
all
of
which
facilitate
biomolecular
sensing
self-assembly.
Advanced Materials,
Год журнала:
2023,
Номер
36(10)
Опубликована: Фев. 16, 2023
Abstract
The
growing
interest
in
nanomedicine
over
the
last
20
years
has
carved
out
a
research
field
called
“nanocatalytic
therapy,”
where
catalytic
reactions
mediated
by
nanomaterials
are
employed
to
intervene
disease‐critical
biomolecular
processes.
Among
many
kinds
of
catalytic/enzyme‐mimetic
investigated
thus
far,
ceria
nanoparticles
stand
from
others
owing
their
unique
scavenging
properties
against
biologically
noxious
free
radicals,
including
reactive
oxygen
species
(ROS)
and
nitrogen
(RNS),
exerting
enzyme
mimicry
nonenzymatic
activities.
Much
effort
been
made
utilize
as
self‐regenerating
antioxidative
anti‐inflammatory
agents
for
various
diseases,
given
detrimental
effects
ROS
RNS
therein
that
need
alleviation.
In
this
context,
review
is
intended
provide
an
overview
what
makes
merit
attention
disease
therapy.
introductory
part
describes
characteristics
oxygen‐deficient
metal
oxide.
pathophysiological
roles
then
presented,
well
mechanisms
nanoparticles.
Representative
examples
recent
ceria‐nanoparticle‐based
therapeutics
summarized
categorization
into
organ
types,
followed
discussion
on
remaining
challenges
future
directions.
Chemical Reviews,
Год журнала:
2023,
Номер
123(18), С. 10920 - 10989
Опубликована: Сен. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Journal of the American Chemical Society,
Год журнала:
2023,
Номер
145(8), С. 4366 - 4371
Опубликована: Янв. 20, 2023
Innovative
methods
for
engineering
cancer
cell
membranes
promise
to
manipulate
cell–cell
interactions
and
boost
cell-based
therapeutics.
Here,
we
illustrate
an
in
situ
approach
selectively
modify
by
employing
enzyme-instructed
peptide
self-assembly
(EISA)
strategy.
Using
three
phosphopeptides
(pY1,
pY2,
pY3)
targeting
the
membrane-bound
epidermal
growth
factor
receptor
(EGFR)
differing
just
one
phosphorylated
tyrosine,
reveal
that
site-specific
phosphorylation
patterns
pY1,
pY3
can
distinctly
command
their
preorganization
levels,
self-assembling
kinetics,
spatial
distributions
of
resultant
assemblies
cellulo.
Overall,
pY1
is
most
capable
producing
preorganized
shows
fastest
dephosphorylation
reaction
presence
alkaline
phosphatase
(ALP),
as
well
highest
binding
affinity
EGFR
after
dephosphorylation.
Consequently,
exhibits
greatest
capacity
construct
stable
on
with
assistance
both
ALP
EGFR.
We
further
use
peptide–protein
peptide–peptide
co-assembly
strategies
apply
two
types
antigens,
namely
ovalbumin
(OVA)
protein
dinitrophenyl
(DNP)
hapten
respectively,
membranes.
This
study
demonstrates
a
very
useful
technique
construction
around
cells
implies
versatile
strategy
artificially
enrich
membrane
components
potential
immunotherapy.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Фев. 13, 2023
Temporal
control
of
delivery
and
release
drugs
in
tumors
are
important
improving
therapeutic
outcomes
to
patients.
Here,
we
report
a
sequential
stimuli-triggered
situ
self-assembly
disassembly
strategy
direct
theranostic
vivo.
Using
cisplatin
as
model
anticancer
drug,
design
stimuli-responsive
small-molecule
prodrug
(P-CyPt),
which
undergoes
extracellular
alkaline
phosphatase-triggered
succeeding
intracellular
glutathione-triggered
process,
allowing
enhance
accumulation
elicit
burst
tumor
cells.
Compared
with
cisplatin,
P-CyPt
greatly
improves
antitumor
efficacy
while
mitigates
off-target
toxicity
mice
subcutaneous
HeLa
orthotopic
HepG2
liver
after
systemic
administration.
Moreover,
also
produces
activated
near-infrared
fluorescence
(at
710
nm)
dual
photoacoustic
imaging
signals
700
750
nm),
permitting
high
sensitivity
spatial-resolution
delineation
foci
real-time
monitoring
drug
This
leverages
the
advantages
offered
by
those
disassembly,
may
act
general
platform
for
prodrugs
capable
cancer
theranostics.
Manipulating
molecular
vivo
permit
temporal
release.
authors
fluorogenic
theranostics
leveraging
processes.
Abstract
Dynamic‐responsive
self‐assembly
is
the
process
of
ordered
supramolecular
structure
formation
or
reversible
decomposition
from
building
blocks.
This
driven
by
non‐covalent
interactions
based
on
complex
stimulus‐responsive
systems
comprising
different
components
within
a
microenvironment.
Furthermore,
stimuli‐responsive
assembly‐disassembly
an
intrinsic
interaction
in
organisms,
indispensable
maintaining
life
activities
and
functions.
However,
dynamic
between
dynamically
responsive
nano‐drug
(DRNSs)
biological
remain
unpredictable,
which
are
challenge
for
precisely
targeted
therapy
controlled
drug
release
DRNSs
vivo.
review
highlights
novel
self‐assembling
peptide‐based
their
interactions.
By
controlling
shape
size
self‐assembled
peptide
nanomaterials,
biologically
simulated
with
diverse
functions
precise
transport
at
subcellular
level
can
be
achieved.
We
have
also
summarized
limitations
challenges
nanomaterials
clinical
translation.
Additionally,
we
discussed
future
perspectives
therapeutics
using
signaling
molecule
gradient
concentrations
efficiencies
highlighted
direction
developing
clinically
translatable
smart
nanomedicines.
