Self-Amplifying Assembly of Peptides in Macrophages for Enhanced Inflammatory Treatment DOI
Yanqiu Song, Mingming Li, Na Song

и другие.

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(15), С. 6907 - 6917

Опубликована: Апрель 7, 2022

Enzyme-regulated in situ self-assembly of peptides represents one versatile strategy the creation theranostic agents, which, however, is limited by strong dependence on enzyme overexpression. Herein, we reported self-amplifying assembly precisely macrophages associated with expression for improving anti-inflammatory efficacy conventional drugs. The assembling system was created via coassembling an enzyme-responsive peptide its derivative functionalized a protein ligand. Reduction NAD(P)H quinone dehydrogenase 1 (NQO1) led to formation nanofibers high affinity protein, thereby facilitating NQO1 expression. improved level conversely promoted into nanofibers, thus establishing amplifying relationship between and macrophages. Utilization as vehicles drug dexamethasone allowed passive targeting delivery acute injured lungs. Both vitro vivo studies confirmed capability enhance simultaneous alleviation reactive oxygen species side effect downregulation proinflammatory cytokines. Our findings demonstrate manipulation living cells regular self-amplification process, providing unique supramolecular agents cells.

Язык: Английский

Recognition in the Domain of Molecular Chirality: From Noncovalent Interactions to Separation of Enantiomers DOI
Paola Peluso, Bezhan Chankvetadze

Chemical Reviews, Год журнала: 2022, Номер 122(16), С. 13235 - 13400

Опубликована: Авг. 2, 2022

It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in nature synthetic molecular systems. Noncovalent interactivity between chiral molecules underlies enantioselective recognition as fundamental phenomenon regulating life human activities. Thus, represent the narrative thread of fascinating story which goes across several disciplines medical, chemical, physical, biological, other natural sciences. This review has been conceived with awareness modern attitude toward its consequences needs to be founded on multidisciplinary approaches disclose basis essential phenomena domain With primary aim discussing this topic an integrated way, comprehensive pool rational systematic information provided, concerns fundamentals chirality, description interactions, their implications processes occurring different contexts. A specific focus devoted enantioselection chromatography electromigration techniques because unique feature "multistep" processes. second motivation for writing make clear statement about state art, tools we have at our disposal, what still missing fully understand mechanisms underlying recognition.

Язык: Английский

Процитировано

184

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications DOI
Chenyang Jiang, Haojie Huang,

Xueying Kang

и другие.

Chemical Society Reviews, Год журнала: 2021, Номер 50(13), С. 7436 - 7495

Опубликована: Янв. 1, 2021

Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit high reactivity toward biological nucleophilies accompanied by distinct colorimetric and fluorescent changes, environmental sensitivity, small size, all of which facilitate biomolecular sensing self-assembly.

Язык: Английский

Процитировано

148

(Macro)molecular self-assembly for hydrogel drug delivery DOI Creative Commons
Matthew J. Webber, E. Thomas Pashuck

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 172, С. 275 - 295

Опубликована: Янв. 13, 2021

Язык: Английский

Процитировано

145

Ceria‐Based Therapeutic Antioxidants for Biomedical Applications DOI

Young Geon Kim,

Yun‐Jung Lee, Nohyun Lee

и другие.

Advanced Materials, Год журнала: 2023, Номер 36(10)

Опубликована: Фев. 16, 2023

Abstract The growing interest in nanomedicine over the last 20 years has carved out a research field called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are employed to intervene disease‐critical biomolecular processes. Among many kinds of catalytic/enzyme‐mimetic investigated thus far, ceria nanoparticles stand from others owing their unique scavenging properties against biologically noxious free radicals, including reactive oxygen species (ROS) and nitrogen (RNS), exerting enzyme mimicry nonenzymatic activities. Much effort been made utilize as self‐regenerating antioxidative anti‐inflammatory agents for various diseases, given detrimental effects ROS RNS therein that need alleviation. In this context, review is intended provide an overview what makes merit attention disease therapy. introductory part describes characteristics oxygen‐deficient metal oxide. pathophysiological roles then presented, well mechanisms nanoparticles. Representative examples recent ceria‐nanoparticle‐based therapeutics summarized categorization into organ types, followed discussion on remaining challenges future directions.

Язык: Английский

Процитировано

103

Tumor Abnormality-Oriented Nanomedicine Design DOI
Quan Zhou, Jiajia Xiang, Nasha Qiu

и другие.

Chemical Reviews, Год журнала: 2023, Номер 123(18), С. 10920 - 10989

Опубликована: Сен. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Язык: Английский

Процитировано

86

Enzyme-Instructed Peptide Assembly Favored by Preorganization for Cancer Cell Membrane Engineering DOI

Yinghao Ding,

Debin Zheng,

Li‐Min Xie

и другие.

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(8), С. 4366 - 4371

Опубликована: Янв. 20, 2023

Innovative methods for engineering cancer cell membranes promise to manipulate cell–cell interactions and boost cell-based therapeutics. Here, we illustrate an in situ approach selectively modify by employing enzyme-instructed peptide self-assembly (EISA) strategy. Using three phosphopeptides (pY1, pY2, pY3) targeting the membrane-bound epidermal growth factor receptor (EGFR) differing just one phosphorylated tyrosine, reveal that site-specific phosphorylation patterns pY1, pY3 can distinctly command their preorganization levels, self-assembling kinetics, spatial distributions of resultant assemblies cellulo. Overall, pY1 is most capable producing preorganized shows fastest dephosphorylation reaction presence alkaline phosphatase (ALP), as well highest binding affinity EGFR after dephosphorylation. Consequently, exhibits greatest capacity construct stable on with assistance both ALP EGFR. We further use peptide–protein peptide–peptide co-assembly strategies apply two types antigens, namely ovalbumin (OVA) protein dinitrophenyl (DNP) hapten respectively, membranes. This study demonstrates a very useful technique construction around cells implies versatile strategy artificially enrich membrane components potential immunotherapy.

Язык: Английский

Процитировано

84

Controlled sequential in situ self-assembly and disassembly of a fluorogenic cisplatin prodrug for cancer theranostics DOI Creative Commons

Xidan Wen,

Rui Zhang, Yuxuan Hu

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Фев. 13, 2023

Temporal control of delivery and release drugs in tumors are important improving therapeutic outcomes to patients. Here, we report a sequential stimuli-triggered situ self-assembly disassembly strategy direct theranostic vivo. Using cisplatin as model anticancer drug, design stimuli-responsive small-molecule prodrug (P-CyPt), which undergoes extracellular alkaline phosphatase-triggered succeeding intracellular glutathione-triggered process, allowing enhance accumulation elicit burst tumor cells. Compared with cisplatin, P-CyPt greatly improves antitumor efficacy while mitigates off-target toxicity mice subcutaneous HeLa orthotopic HepG2 liver after systemic administration. Moreover, also produces activated near-infrared fluorescence (at 710 nm) dual photoacoustic imaging signals 700 750 nm), permitting high sensitivity spatial-resolution delineation foci real-time monitoring drug This leverages the advantages offered by those disassembly, may act general platform for prodrugs capable cancer theranostics. Manipulating molecular vivo permit temporal release. authors fluorogenic theranostics leveraging processes.

Язык: Английский

Процитировано

81

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems DOI Creative Commons
Yuhan Wang, Jie Zhan,

Jinyan Huang

и другие.

Deleted Journal, Год журнала: 2023, Номер 1(1)

Опубликована: Янв. 1, 2023

Abstract Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure formation or reversible decomposition from building blocks. This driven by non‐covalent interactions based on complex stimulus‐responsive systems comprising different components within a microenvironment. Furthermore, stimuli‐responsive assembly‐disassembly an intrinsic interaction in organisms, indispensable maintaining life activities and functions. However, dynamic between dynamically responsive nano‐drug (DRNSs) biological remain unpredictable, which are challenge for precisely targeted therapy controlled drug release DRNSs vivo. review highlights novel self‐assembling peptide‐based their interactions. By controlling shape size self‐assembled peptide nanomaterials, biologically simulated with diverse functions precise transport at subcellular level can be achieved. We have also summarized limitations challenges nanomaterials clinical translation. Additionally, we discussed future perspectives therapeutics using signaling molecule gradient concentrations efficiencies highlighted direction developing clinically translatable smart nanomedicines.

Язык: Английский

Процитировано

57

Supramolecular gels – a panorama of low-molecular-weight gelators from ancient origins to next-generation technologies DOI Creative Commons
David K. Smith

Soft Matter, Год журнала: 2023, Номер 20(1), С. 10 - 70

Опубликована: Дек. 11, 2023

Supramolecular gels, self-assembled from low-molecular-weight gelators (LMWGs), have a long history and bright future.

Язык: Английский

Процитировано

51

Cell spheroid creation by transcytotic intercellular gelation DOI
Jiaqi Guo, Fengbin Wang, Yimeng Huang

и другие.

Nature Nanotechnology, Год журнала: 2023, Номер 18(9), С. 1094 - 1104

Опубликована: Май 22, 2023

Язык: Английский

Процитировано

50