Advanced Materials,
Год журнала:
2024,
Номер
36(33)
Опубликована: Июнь 6, 2024
The
growing
aging
population,
with
its
associated
chronic
diseases,
underscores
the
urgency
for
effective
tissue
regeneration
strategies.
Biomaterials
play
a
pivotal
role
in
realm
of
reconstruction
and
regeneration,
distinct
shift
toward
minimally
invasive
(MI)
treatments.
This
transition,
fueled
by
engineered
biomaterials,
steers
away
from
surgical
procedures
to
embrace
approaches
offering
reduced
trauma,
accelerated
recovery,
cost-effectiveness.
In
MI
repair
cargo
delivery,
various
techniques
are
explored.
While
situ
polymerization
is
prominent,
it
not
without
challenges.
narrative
review
explores
diverse
fabrication
methods,
biofunctionalization
injectable
pre-formed
scaffolds,
focusing
on
their
unique
advantages.
exhibiting
compressibility,
controlled
injection,
maintained
mechanical
integrity,
emerge
as
promising
alternative
solutions
conclusion
this
emphasizes
importance
interdisciplinary
design
facilitated
synergizing
fields
materials
science,
advanced
3D
biomanufacturing,
mechanobiological
studies,
innovative
regeneration.
Nano-Micro Letters,
Год журнала:
2023,
Номер
15(1)
Опубликована: Фев. 15, 2023
Abstract
Flexible
hydrogels
are
receiving
significant
attention
for
their
application
in
wearable
sensors.
However,
most
hydrogel
materials
exhibit
weak
and
one-time
adhesion,
low
sensitivity,
ice
crystallization,
water
evaporation,
poor
self-recovery,
thereby
limiting
as
These
issues
only
partly
addressed
previous
studies.
Herein,
a
multiple-crosslinked
poly(2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium
hydroxide-co-acrylamide)
(P(SBMA-co-AAm))
multifunctional
is
prepared
via
one-pot
synthesis
method
to
overcome
the
aforementioned
limitations.
Specifically,
ions,
glycerol,
2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium
hydroxide
incorporated
reduce
freezing
point
improve
moisture
retention
ability.
The
proposed
superior
existing
because
it
exhibits
good
stretchability
(a
strain
of
2900%),
self-healing
properties,
transparency
through
effective
energy
dissipation
its
dynamic
crosslinked
network.
Further,
zwitterion
monomer
results
an
excellent
gauge
factor
43.4
at
strains
1300–1600%
by
improving
ion
transportability
achieving
strong
adhesion
20.9
kPa
owing
dipole–dipole
moment.
promising
next-generation
biomedical
applications,
such
soft
robots,
health
monitoring.
Materials Horizons,
Год журнала:
2023,
Номер
11(1), С. 37 - 101
Опубликована: Окт. 27, 2023
The
unique
network
characteristics
and
stimuli
responsiveness
of
supramolecular
hydrogels
have
rendered
them
highly
advantageous
in
the
field
wound
dressings,
showcasing
unprecedented
potential.
However,
there
are
few
reports
on
a
comprehensive
review
hydrogel
dressings
for
repair
hemostasis.
This
first
introduces
major
cross-linking
methods
hydrogels,
which
includes
hydrogen
bonding,
electrostatic
interactions,
hydrophobic
host-guest
metal
ligand
coordination
some
other
interactions.
Then,
we
advanced
materials
reported
recent
years
then
summarize
basic
principles
each
method.
Next,
classify
structures
before
outlining
their
forming
process
propose
potential
future
directions.
Furthermore,
also
discuss
raw
materials,
structural
design
principles,
material
used
to
achieve
functions
such
as
antibacterial
function,
tissue
adhesion,
substance
delivery,
anti-inflammatory
antioxidant
functions,
cell
behavior
regulation,
angiogenesis
promotion,
hemostasis
innovative
years.
Finally,
existing
problems
well
development
directions
strategy,
design,
discussed.
is
proposed
stimulate
further
exploration
by
researchers
future.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 215 - 215
Опубликована: Фев. 7, 2025
Conventional
drug
delivery
approaches,
including
tablets
and
capsules,
often
suffer
from
reduced
therapeutic
effectiveness,
largely
attributed
to
inadequate
bioavailability
difficulties
in
ensuring
patient
adherence.
These
challenges
have
driven
the
development
of
advanced
systems
(DDS),
with
hydrogels
especially
nanogels
emerging
as
promising
materials
overcome
these
limitations.
Hydrogels,
their
biocompatibility,
high
water
content,
stimuli-responsive
properties,
provide
controlled
targeted
release.
This
review
explores
evolution,
classifications
versus
applications
delivery,
detailing
synthesis
methods,
chemical
crosslinking,
physical
self-assembly,
techniques
such
microfluidics
3D
printing.
It
also
examines
drug-loading
mechanisms
(e.g.,
encapsulation
electrostatic
interactions)
release
strategies
diffusion,
stimuli-responsive,
enzyme-triggered).
gels
demonstrate
significant
advantages
addressing
limitations
traditional
DDS,
offering
improved
stability,
sustained
release,
specificity.
Their
adaptability
extends
various
routes
administration,
topical,
oral,
injectable
forms,
while
further
enhance
targeting
through
nanoscale
precision
stimuli
responsiveness.
Although
transformative
potential
personalized
medicine,
remain
scalable
manufacturing,
regulatory
approval,
delivery.
Future
include
integrating
biosensors
for
real-time
monitoring,
developing
dual-stimuli-responsive
systems,
optimizing
surface
functionalization
advancements
aim
establish
cornerstones
next-generation
solutions,
revolutionizing
paving
way
innovative,
patient-centered
treatments.
