Explaining chemical clues of metal organic framework-nanozyme nano-/micro-motors in targeted treatment of cancers: benchmarks and challenges DOI Creative Commons
Mojtaba Falahati, Majid Sharifi, Timo L.M. ten Hagen

и другие.

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Март 24, 2022

Nowadays, nano-/micro-motors are considered as powerful tools in different areas ranging from cleaning all types of contaminants, to development Targeted drug delivery systems and diagnostic activities. Therefore, the application based on metal-organic frameworks with nanozyme activity (abbreviated as: MOF-NZs) biomedical activities have received much interest recently. after investigating catalytic properties applications MOF-NZs treatment cancer, this study intends point out their key role production biocompatible nano-/micro-motors. Since reducing toxicity MOF-NZ can pave way for medical activities, article examines methods making nanomotors address benefits drawbacks required propellants. In following, an analysis amplified directional motion under physiological conditions is presented, which improve motor behaviors propulsion function, conductivity, targeting, release, possible elimination. Meanwhile, by explaining use cancer through synergy therapies, it was revealed that be effective cancer. Ultimately, analyzing potential challenges cancers, we hope encourage researchers develop MOF-NZs-based nanomotors, addition opening up new ideas ongoing problems.

Язык: Английский

Magnetically Driven Micro and Nanorobots DOI Creative Commons
Huaijuan Zhou, Carmen C. Mayorga‐Martinez, Salvador Pané

и другие.

Chemical Reviews, Год журнала: 2021, Номер 121(8), С. 4999 - 5041

Опубликована: Март 31, 2021

Manipulation and navigation of micro nanoswimmers in different fluid environments can be achieved by chemicals, external fields, or even motile cells. Many researchers have selected magnetic fields as the active actuation source based on advantageous features this strategy such remote spatiotemporal control, fuel-free, high degree reconfigurability, programmability, recyclability, versatility. This review introduces fundamental concepts advantages micro/nanorobots (termed here "MagRobots") well basic knowledge materials, setups for manipulation, field configurations, symmetry-breaking strategies effective movement. These are discussed to describe interactions between fields. Actuation mechanisms flagella-inspired MagRobots (i.e., corkscrew-like motion traveling-wave locomotion/ciliary stroke motion) surface walkers surface-assisted motion), applications other propulsion approaches, stimulation beyond provided followed fabrication techniques (quasi-)spherical, helical, flexible, wire-like, biohybrid MagRobots. Applications targeted drug/gene delivery, cell minimally invasive surgery, biopsy, biofilm disruption/eradication, imaging-guided delivery/therapy/surgery, pollution removal environmental remediation, (bio)sensing also reviewed. Finally, current challenges future perspectives development magnetically powered miniaturized motors discussed.

Язык: Английский

Процитировано

572

Molecular Pumps and Motors DOI
Yuanning Feng, Marco Ovalle, James S. W. Seale

и другие.

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(15), С. 5569 - 5591

Опубликована: Апрель 8, 2021

Pumps and motors are essential components of the world as we know it. From complex proteins that sustain our cells, to mechanical marvels power industries, much take for granted is only possible because pumps motors. Although molecular have supported life eons, it recently chemists made progress toward designing building artificial forms microscopic machinery present in nature. The advent machines has scientists an unprecedented level control over relative motion molecules through development kinetically controlled, away-from-thermodynamic equilibrium chemistry. We outline history motors, focusing specifically on innovations enable design synthesis central this Perspective. A key insight connecting biomolecular physical motions by which these carry out their function unambiguously at every instant. operation can be described trajectory thermodynamics, a theory based work Onsager, grounded firm foundation principle reversibility. Free energy derived from thermodynamically non-equilibrium reactions favors some reaction pathways others. By with kinetic asymmetry, one engineer potential landscapes harness external drive formation maintenance geometries component parts away-from-equilibrium, would impossible achieve standard synthetic approaches.

Язык: Английский

Процитировано

200

Antibacterial mechanisms and applications of metal-organic frameworks and their derived nanomaterials DOI
Jianghua Liu, Di Wu,

Niu Zhu

и другие.

Trends in Food Science & Technology, Год журнала: 2021, Номер 109, С. 413 - 434

Опубликована: Янв. 12, 2021

Язык: Английский

Процитировано

189

Morphology control through the synthesis of metal-organic frameworks DOI Creative Commons
Justyna Łuczak, Malwina Kroczewska, Mateusz A. Baluk

и другие.

Advances in Colloid and Interface Science, Год журнала: 2023, Номер 314, С. 102864 - 102864

Опубликована: Фев. 26, 2023

Designable morphology and predictable properties are the most challenging goals in material engineering. Features such as shape, size, porosity, agglomeration ratio significantly affect final of metal-organic frameworks (MOFs) can be regulated throughout synthesis parameters but require a deep understanding mechanisms MOFs formation. Herein, we systematically summarize effects individual factors, pH reaction mixture, including acidic or basic character modulators, temperature, solvents types, surfactants type content ionic liquids on growing MOFs. We identified main MOFs' growth leading to different particles next discuss effect miscellaneous based related nucleation, formation structure, coordination modulation, protonation/deprotonation acting modulation by capping agents. The microwaves ultrasound employment during is also considered due their affecting especially nucleation steps

Язык: Английский

Процитировано

139

Microplastic Removal and Degradation by Mussel‐Inspired Adhesive Magnetic/Enzymatic Microrobots DOI
Huaijuan Zhou, Carmen C. Mayorga‐Martinez, Martin Pumera

и другие.

Small Methods, Год журнала: 2021, Номер 5(9)

Опубликована: Авг. 15, 2021

Abstract Ubiquitous pollution by microplastics is causing significant deleterious effects on marine life and human health through the food chain has become a big challenge for global ecosystem. It of great urgency to find cost‐efficient biocompatible material remove from environment. Mimicking basic characteristics adhesive chemistry practiced mussels, polydopamine (PDA)@Fe 3 O 4 magnetic microrobots (MagRobots) are prepared coating Fe nanoparticles with polymeric layer dopamine via one‐step self‐polymerization. In addition, lipase loaded PDA@Fe MagRobots’ surface perform microplastic enzymatic degradation. The synthesized MagRobots, which externally triggered transversal rotating field, have capacity clear away targeted due their strong sticky characteristics. With MagRobots surfaces, can be navigated along an arbitrarily predefined path field removed using directional field. Such envisioned used in swarms aqueous environments.

Язык: Английский

Процитировано

110

Lighting up Micro-/Nanorobots with Fluorescence DOI
Manyi Yang,

Xia Guo,

Fangzhi Mou

и другие.

Chemical Reviews, Год журнала: 2022, Номер 123(7), С. 3944 - 3975

Опубликована: Сен. 15, 2022

Micro-/nanorobots (MNRs) can be autonomously propelled on demand in complex biological environments and thus may bring revolutionary changes to biomedicines. Fluorescence has been widely used real-time imaging, chemo-/biosensing, photo-(chemo-) therapy. The integration of MNRs with fluorescence generates fluorescent unique advantages optical trackability, on-the-fly environmental sensitivity, targeting chemo-/photon-induced cytotoxicity. This review provides an up-to-date overview MNRs. After the highlighted elucidation about various propulsion mechanisms introductory information emphasis materials, we systematically illustrate design preparation strategies integrate substances their biomedical applications imaging-guided drug delivery, intelligent sensing In end, summarize main challenges provide outlook future directions work is expected attract inspire researchers from different communities advance creation practical application a broad horizon.

Язык: Английский

Процитировано

85

Magnetically Actuated Medical Robots: An in vivo Perspective DOI
Bradley J. Nelson, Simone Gervasoni, Philip Wai Yan Chiu

и другие.

Proceedings of the IEEE, Год журнала: 2022, Номер 110(7), С. 1028 - 1037

Опубликована: Апрель 28, 2022

The use of magnetic fields and field gradients to move material devices within the human body has a surprisingly long history. Over past two decades, there been renewed interest in this area with growth medical microrobots. In article, we focus on state-of-the-art future directions for magnetically actuated robots from an in vivo perspective. We initially review history relevant physics followed by discussion limited research efforts that investigate guided devices. Our is tethered probes, untethered (microrobots nanorobots), navigation systems have or could be utilized provide increased control safety physician patient.

Язык: Английский

Процитировано

72

Ultrasound trapping and navigation of microrobots in the mouse brain vasculature DOI Creative Commons
Alexia Del Campo Fonseca, Chaim Glück,

Jeanne Droux

и другие.

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 21, 2023

The intricate and delicate anatomy of the brain poses significant challenges for treatment cerebrovascular neurodegenerative diseases. Thus, precise local drug delivery in hard-to-reach regions remains an urgent medical need. Microrobots offer potential solutions; however, their functionality restricted by limited imaging capabilities complications within blood vessels, such as high flows, osmotic pressures, cellular responses. Here, we introduce ultrasound-activated microrobots vivo navigation vasculature. Our consist lipid-shelled microbubbles that autonomously aggregate propel under ultrasound irradiation. We investigate capacities vitro microfluidic-based vasculatures vessels a living mouse brain. These self-assemble execute upstream motion vasculature, achieving velocities up to 1.5 µm/s moving against flows ~10 mm/s. This work represents substantial advance towards therapeutic application complex

Язык: Английский

Процитировано

50

Research progress on antibacterial applications of metal-organic frameworks and their biomacromolecule composites DOI

Lei Guo,

Wei Kong,

Yilin Che

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 261, С. 129799 - 129799

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

22

Advanced materials for micro/nanorobotics DOI Creative Commons
Jeonghyo Kim, Paula Mayorga Burrezo, Su-Jin Song

и другие.

Chemical Society Reviews, Год журнала: 2024, Номер 53(18), С. 9190 - 9253

Опубликована: Янв. 1, 2024

Autonomous micro/nanorobots capable of performing programmed missions are at the forefront next-generation micromachinery. These small robotic systems predominantly constructed using functional components sourced from micro- and nanoscale materials; therefore, combining them with various advanced materials represents a pivotal direction toward achieving higher level intelligence multifunctionality. This review provides comprehensive overview for innovative micro/nanorobotics, focusing on five families that have witnessed most rapid advancements over last decade: two-dimensional materials, metal-organic frameworks, semiconductors, polymers, biological cells. Their unique physicochemical, mechanical, optical, properties been integrated into to achieve greater maneuverability, programmability, intelligence, multifunctionality in collective behaviors. The design fabrication methods hybrid discussed based material categories. In addition, their promising potential powering motion and/or (multi-)functionality is described fundamental principles underlying explained. Finally, extensive use variety applications, including environmental remediation, (bio)sensing, therapeutics,

Язык: Английский

Процитировано

18