Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016–2022)

Pharmaceuticals, Год журнала: 2023, Номер 16(8), С. 1162 - 1162

Опубликована: Авг. 15, 2023

Fluorine is characterized by high electronegativity and small atomic size, which provide this molecule with the unique property of augmenting potency, selectivity, metabolic stability, pharmacokinetics drugs. (F) substitution has been extensively explored in drug research as a means improving biological activity enhancing chemical or stability. Selective F onto therapeutic diagnostic candidate can enhance several pharmacokinetic physicochemical properties such stability membrane permeation. The increased binding ability fluorinated target proteins also reported some cases. An emerging line on addressed using 18F radiolabel tracer atom extremely sensitive methodology positron emission tomography (PET) imaging. This review aims to report drugs approved US Food Drug Administration (FDA) from 2016 2022. It cites selected examples variety FDA-approved period have heterocyclic cores, including pyrrole, pyrazole, imidazole, triazole, pyridine, pyridone, pyridazine, pyrazine, pyrimidine, triazine, purine, indole, benzimidazole, isoquinoline, quinoline appended either F-18 F-19. Some oligonucleotides were authorized FDA between 2019

Язык: Английский

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Latest developments in coumarin-based anticancer agents: mechanism of action and structure–activity relationship studies

RSC Medicinal Chemistry, Год журнала: 2023, Номер 15(1), С. 10 - 54

Опубликована: Окт. 20, 2023

Many researchers around the world are working on development of novel anticancer drugs with different mechanisms action. In this case, coumarin is a highly promising pharmacophore for drugs. Besides, hybridization moiety other pharmacophores has emerged as potent breakthrough in treatment cancer to decrease its side effects and increase efficiency. This review aims provide comprehensive overview recent derivatives their application Herein, we highlight describe largest number research works reported field from 2015 August 2023, along action structure-activity relationship studies, making articles published topic date.

Язык: Английский

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Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications

Chemical Reviews, Год журнала: 2024, Номер 124(15), С. 8825 - 9014

Опубликована: Июль 25, 2024

Luminescence imaging is a powerful and versatile technique for investigating cell physiology pathology in living systems, making significant contributions to life science research clinical diagnosis. In recent years, luminescent transition metal complexes have gained attention diagnostic therapeutic applications due their unique photophysical photochemical properties. this Review, we provide comprehensive overview of the development bioimaging biosensing applications, with focus on centers d

Язык: Английский

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Water-based layer-by-layer processing enables 19% efficient binary organic solar cells with minimized thickness sensitivity

Energy & Environmental Science, Год журнала: 2024, Номер 17(7), С. 2441 - 2452

Опубликована: Янв. 1, 2024

A mesoporous layer was constructed by a donor-based nanoparticulate water-ink, which facilitates the infiltration of acceptor, allowing fabrication efficient organic solar cells with high thickness tolerance.

Язык: Английский

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Anti-moisture, anti-bacterial cellulosic triboelectric materials enabled by hydroxyl coordination effect

Nano Energy, Год журнала: 2024, Номер 124, С. 109472 - 109472

Опубликована: Март 8, 2024

Язык: Английский

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FDA approved fluorine-containing drugs in 2023

Chinese Chemical Letters, Год журнала: 2024, Номер 35(11), С. 109780 - 109780

Опубликована: Март 15, 2024

Язык: Английский

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Insights into sensing applications of fluorescent covalent organic frameworks

TrAC Trends in Analytical Chemistry, Год журнала: 2024, Номер 173, С. 117625 - 117625

Опубликована: Фев. 27, 2024

Язык: Английский

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Deep optimization of water quality index and positive matrix factorization models for water quality evaluation and pollution source apportionment using a random forest model

Environmental Pollution, Год журнала: 2024, Номер 347, С. 123771 - 123771

Опубликована: Март 15, 2024

Язык: Английский

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High organofluorine concentrations in municipal wastewater affect downstream drinking water supplies for millions of Americans

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(3)

Опубликована: Янв. 6, 2025

Wastewater receives per- and polyfluoroalkyl substances (PFAS) from diverse consumer industrial sources, discharges are known to be a concern for drinking water quality. The PFAS family includes thousands of potential chemical structures containing organofluorine moieties. Exposures few well-studied PFAS, mainly perfluoroalkyl acids (PFAA), have been associated with increased risk many adverse health outcomes, prompting federal regulations six compounds in 2024. Here, we find that the regulated (mean = 7 8%) 18 measured PFAA 11 21%) make up only small fraction extractable (EOF) influent effluent eight large municipal wastewater treatment facilities. Most EOF (75%) (62%) consists mono- polyfluorinated pharmaceuticals. technology sizes facilities this study similar those serving 70% US population. Despite advanced technologies, maximum removal efficiency among work was <25%. Extrapolating our measurements other across United States results nationwide discharge estimate 1.0 2.8 million moles F y-1. Using national model simulates connections between downstream intakes, sources 23 Americans could contaminated above regulatory thresholds by wastewater-derived alone. These emphasize importance further curbing ongoing additional evaluations fate toxicity fluorinated

Язык: Английский

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Substitution–Leaching–Deposition (SLD) Processes Drive Reversible Surface Layer Reconstruction of Metal Oxides for Fluoride Adsorption

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Surface complexation has long been recognized as the basic mode involved in fluoride adsorption onto metal oxides. However, such general recognition is challenged by unusual pH dependence observed adsorption. Here, we selected hydrated zirconium oxide (HZO) a representative to revisit mechanism. Multiple situ microscopic analyses and thermodynamic simulations suggest that, unlike of other anions that proceed exclusively via substituting protonated terminal hydroxyl (η-OH2+) groups oxides, can displace both η-OH2+ bridging (μ-OH+) HZO (i.e., Substitution). This distinctive displacement drives leaching Zr from HZO, generating aqueous polyfluorozirconium complexes Leaching) which subsequently deposit outer-sphere Deposition). The adsorbed gradually converts into fluorozirconate (Na5Zr2F13) coating, resulting surface layer reconstruction up 100 nm depth. atypical dependency be explained processes Substitution, Leaching, Deposition SLD processes). More attractively, SLD-driven reversible nature, ensuring constant defluoridation capability during cyclic adsorption-desorption assays. study advances our understanding at water-metal interfaces.

Язык: Английский

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