Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(5), С. 3483 - 3491
Опубликована: Янв. 24, 2024
Planar
chiral
ferrocenyl
phosphines
have
been
employed
as
highly
valuable
ligands
in
metal-catalyzed
asymmetric
reactions.
However,
their
preparation
remains
a
formidable
challenge
due
to
the
requirement
for
intricate,
multistep
synthetic
sequences.
In
addressing
this
issue,
we
developed
groundbreaking
enantioselective
C-H
activation
strategy
facilitated
by
P(III)
directing
groups,
enabling
efficient
construction
of
planar
single
step.
Our
innovative
approach
entails
combination
palladium
catalyst,
parent
phosphine,
and
phosphoramidite
ligand,
leading
exceptional
reactivity
enantioselectivity.
Remarkably,
these
novel
exhibit
remarkable
efficacy
silver-catalyzed
1,3-dipolar
cycloadditions.
We
carried
out
experimental
computational
studies
obtain
more
comprehensive
understanding
reaction
pathway
factors
contributing
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(14), С. 4024 - 4040
Опубликована: Янв. 1, 2024
This
review
provides
a
comprehensive
overview
of
metal
catalysis
in
photo-electrochemical
systems,
discussing
reaction
mechanisms
and
offering
prospects
for
this
triadic
catalytic
mode.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(8)
Опубликована: Янв. 6, 2024
Atropisomeric
phosphines
hold
considerable
significance
in
asymmetric
catalysis,
yet
their
synthesis
presents
a
formidable
challenge
owing
to
intricate
multistep
procedures.
In
this
context,
groundbreaking
methodology
has
been
presented
for
preparation.
This
innovative
approach
entails
an
atroposelective
rhodium-catalyzed
C-H
activation
employing
aryl
and
heteroaryl
halides,
chelated
by
P(III)
center.
The
essence
of
strategy
lies
its
ability
directly
construct
chiral
phosphine
ligands
single
step,
thereby
exhibiting
exceptional
efficiency
terms
atom
redox
economy.
Illustrative
examples
serve
demonstrate
the
immense
potential
situ-formed
catalysis.
Mechanistic
experiments
have
further
provided
invaluable
insights
into
transformation.
ACS Chemical Biology,
Год журнала:
2024,
Номер
19(3), С. 774 - 783
Опубликована: Фев. 28, 2024
Enzymes
catalyzing
peptide
macrocyclization
are
important
biochemical
tools
in
drug
discovery.
The
three-residue
cyclophane-forming
enzymes
(3-CyFEs)
an
emerging
family
of
post-translational
modifying
that
catalyze
the
formation
cyclophanes.
In
this
report,
we
introduce
three
additional
3-CyFEs,
including
ChlB,
WnsB,
and
FnnB,
cyclophane
on
Tyr,
Trp,
Phe,
respectively.
To
understand
promiscuity
these
those
previously
reported
(MscB,
HaaB,
YxdB),
tested
single
amino
acid
substitutions
at
motif
modification
(Ω1X2X3,
Ω1
=
aromatic).
Collectively,
observe
substrate
is
observed
X2
positions,
but
a
greater
specificity
for
X3
residue.
Two
nonnative
products
were
characterized
showing
Phe-C3
to
Arg-Cβ
His-C2
Pro-Cβ
cross-links,
We
also
leader
dependence
selected
3-CyFEs
show
predicted
helix
region
formation.
These
results
demonstrate
biocatalytic
potential
maturases
allow
rational
design
substrates
obtain
diverse
array
genetically
encoded
3-residue
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(5), С. 3483 - 3491
Опубликована: Янв. 24, 2024
Planar
chiral
ferrocenyl
phosphines
have
been
employed
as
highly
valuable
ligands
in
metal-catalyzed
asymmetric
reactions.
However,
their
preparation
remains
a
formidable
challenge
due
to
the
requirement
for
intricate,
multistep
synthetic
sequences.
In
addressing
this
issue,
we
developed
groundbreaking
enantioselective
C-H
activation
strategy
facilitated
by
P(III)
directing
groups,
enabling
efficient
construction
of
planar
single
step.
Our
innovative
approach
entails
combination
palladium
catalyst,
parent
phosphine,
and
phosphoramidite
ligand,
leading
exceptional
reactivity
enantioselectivity.
Remarkably,
these
novel
exhibit
remarkable
efficacy
silver-catalyzed
1,3-dipolar
cycloadditions.
We
carried
out
experimental
computational
studies
obtain
more
comprehensive
understanding
reaction
pathway
factors
contributing
