Spatiotemporalized Hydrogel Microspheres Promote Vascularized Osteogenesis via Ultrasound Oxygen Delivery

Advanced Functional Materials, Год журнала: 2023, Номер 34(1)

Опубликована: Сен. 21, 2023

Abstract Disturbance of spatiotemporal oxygen balance is the main cause delayed healing or nonhealing large bone defects. The accurate administration to regulate disruptions in equilibrium during 9 h hypoxia imperative for tissue regeneration. Herein, oxygen‐loaded nanobubbles prepared by double emulsification are successfully embedded GelMA/HepMA microsphere macromolecular meshwork microfluidic techniques, and a spatiotemporalized hydrogel constructed noncovalently binding morphogenetic protein 2 (BMP‐2). microspheres precisely “remote control” release ultrasound vitro after injury homeostasis disorder, maintain high level vascular endothelial growth factor (VEGF) expression, accelerate repair. possess good oxygen‐carrying capacity ultrasonic responsiveness, concentration increases 1.63, 1.95, 2.11, 2.29 times under action at different intensities 1, 2, 3, 4 W, respectively, providing conditions precise regulation disorder ultrasound. In model vivo rat femoral defect model, show vascularization osteogenesis capabilities, which provide new strategy clinical treatment

Язык: Английский

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Exploring recent advancements and future prospects on coordination self-assembly of the regulated lanthanide-doped luminescent supramolecular hydrogels

Coordination Chemistry Reviews, Год журнала: 2023, Номер 499, С. 215486 - 215486

Опубликована: Окт. 27, 2023

Язык: Английский

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Ultrasonic-controlled “explosive” hydrogels to precisely regulate spatiotemporal osteoimmune disturbance

Biomaterials, Год журнала: 2023, Номер 295, С. 122057 - 122057

Опубликована: Фев. 15, 2023

Язык: Английский

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Acoustic Trapping: An Emerging Tool for Microfabrication Technology

Small, Год журнала: 2023, Номер 19(26)

Опубликована: Март 21, 2023

The high throughput deposition of microscale objects with precise spatial arrangement represents a key step in microfabrication technology. This can be done by creating physical boundaries to guide the process or using printing technologies; both approaches, these cannot further modified after they are formed. utilization dynamic acoustic fields offers novel approach facilitate real-time reconfigurable miniaturized systems contactless manner, which potentially used physics, chemistry, biology, as well materials science. Here, interactions an pressure field discussed and how fabricate different trapping devices tune explained. Moreover, approaches that dynamically modulate presented, potential applications microarrays biomedical engineering, chemical/biochemical sensing, science highlighted alongside discussion future research challenges.

Язык: Английский

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Ultrasound-assisted tissue engineering

Nature Reviews Bioengineering, Год журнала: 2024, Номер 2(6), С. 486 - 500

Опубликована: Апрель 2, 2024

Язык: Английский

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