Advanced Functional Materials,
Год журнала:
2024,
Номер
34(46)
Опубликована: Окт. 4, 2024
Abstract
Early
osteoimmune
microenvironment
disorder
at
the
interface
between
bone
and
implant
can
lead
to
loosening,
which
prolongs
patient
convalescence,
exacerbates
postoperative
complications,
potentially
results
in
failure.
The
timely
regulation
of
macrophages
primarily
orchestrates
entire
long‐term
regeneration
process.
Here,
it
is
proposed
precisely
direct
macrophage
polarization
using
localized
photoelectrical
signals
generated
by
an
excitable
surface
response
remote
stimulation
via
near‐infrared
light
(NIR).
photocurrent
from
n–n
heterojunction
calcium
titanate
(CaTiO
3
)
defective
titanium
dioxide
(TiO
2
‐V
o
on
accurately
polarization,
suppressing
acute
inflammation
early
stage
post‐implantation
establishing
a
favorable
that
promotes
bone‐to‐implant
integration.
Mechanistic
study
reveals
photoelectric
initiate
increased
influx
voltage‐gated
ion
channels,
subsequently
modulating
calcium/calmodulin‐dependent
protein
kinase
(Camkk2)
I
(Camk1)
expression
regulate
polarization.
This
optimization
enhanced
mesenchymal
stem
cells
(MSCs)
recruitment
osteogenesis,
ultimately
accelerating
integration
within
14
days
post‐implantation.
research
presents
novel
method
for
adjusting
vivo
spatiotemporal
immune
responses
through
use
noninvasive
externally‐controlled
targeted
stimulations.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(8), С. 5082 - 5106
Опубликована: Июль 15, 2024
In
view
of
their
exceptional
approach,
excellent
inherent
biocompatibility
and
biodegradability
properties,
interaction
with
the
local
extracellular
matrix,
protein-based
polymers
have
received
attention
in
bone
tissue
engineering,
which
is
a
multidisciplinary
field
that
repairs
regenerates
fractured
bones.
Bone
multihierarchical
complex
structure,
it
performs
several
essential
biofunctions,
including
maintaining
mineral
balance
structural
support
protecting
soft
organs.
Protein-based
gained
interest
developing
ideal
scaffolds
as
emerging
biomaterials
for
healing
regeneration,
challenging
to
design
substitutes
perfect
biomaterials.
Several
polymers,
collagen,
keratin,
gelatin,
serum
albumin,
etc.,
are
potential
materials
due
cytocompatibility,
controlled
biodegradability,
high
biofunctionalization,
tunable
mechanical
characteristics.
While
numerous
studies
indicated
encouraging
possibilities
proteins
BTE,
there
still
major
challenges
concerning
stability
physiological
conditions,
continuous
release
growth
factors
bioactive
molecules.
Robust
derived
from
can
be
used
replace
broken
or
diseased
biocompatible
substitute;
proteins,
being
biopolymers,
provide
engineering.
Herein,
recent
developments
protein
cutting-edge
engineering
addressed
this
review
within
3–5
years,
focus
on
significant
future
perspectives.
The
first
section
discusses
fundamentals
anatomy
scaffolds,
second
describes
fabrication
techniques
scaffolds.
third
highlights
importance
applications
BTE.
Hence,
development
state-of-the-art
has
been
discussed,
highlighting
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(12)
Опубликована: Янв. 14, 2024
Abstract
Abnormal
levels
of
reactive
oxygen
species
(ROS)
and
the
hypoxic
microenvironment
within
bone
defects
are
important
factors
that
impede
repair
processes.
Herein,
an
innovative
ultrasound‐modulatable
hydrogel
platform
with
selenoprotein‐mediated
antioxidant
effects
to
promote
injury
is
presented.
This
encapsulates
oxygen‐enriched
selene‐incorporated
thin‐shell
silicon
methacrylate
gelatin
(O
2
‐PSSG).
The
resultant
construct
orchestrates
modulation
bone‐defect
microenvironment,
thereby
expediting
course
regeneration.
Ultrasound
(US)
used
regulate
pore
size
release
selenium‐containing
nanoparticles
in
situ
synthesis
efficient
intracellular
selenoproteins
hydrogen
peroxide
consumption.
As
expected,
O
‐PSSG
rapidly
releases
selenocystine
([Sec]
)
under
US
control
scavenge
maintain
homeostasis
marrow
mesenchymal
stem
cells
(BMSCs).
Over
time,
action
system
by
selenoprotein
increases
activation
Wnt/β‐catenin
pathways
promotes
differentiation
BMSCs.
Consequently,
potentiates
proficiency
BMSCs
both
vitro
vivo,
alleviates
environments,
osteogenic
differentiation,
expedites
cranial
rat
models.
In
summary,
this
study
suggests
designed
constructed
US‐responsive
a
promising
prospective
strategy
for
addressing
fostering
Advanced Functional Materials,
Год журнала:
2023,
Номер
34(1)
Опубликована: Сен. 21, 2023
Abstract
Disturbance
of
spatiotemporal
oxygen
balance
is
the
main
cause
delayed
healing
or
nonhealing
large
bone
defects.
The
accurate
administration
to
regulate
disruptions
in
equilibrium
during
9
h
hypoxia
imperative
for
tissue
regeneration.
Herein,
oxygen‐loaded
nanobubbles
prepared
by
double
emulsification
are
successfully
embedded
GelMA/HepMA
microsphere
macromolecular
meshwork
microfluidic
techniques,
and
a
spatiotemporalized
hydrogel
constructed
noncovalently
binding
morphogenetic
protein
2
(BMP‐2).
microspheres
precisely
“remote
control”
release
ultrasound
vitro
after
injury
homeostasis
disorder,
maintain
high
level
vascular
endothelial
growth
factor
(VEGF)
expression,
accelerate
repair.
possess
good
oxygen‐carrying
capacity
ultrasonic
responsiveness,
concentration
increases
1.63,
1.95,
2.11,
2.29
times
under
action
at
different
intensities
1,
2,
3,
4
W,
respectively,
providing
conditions
precise
regulation
disorder
ultrasound.
In
model
vivo
rat
femoral
defect
model,
show
vascularization
osteogenesis
capabilities,
which
provide
new
strategy
clinical
treatment
Cell
behavior
is
intricately
intertwined
with
the
in
vivo
microenvironment
and
endogenous
pathways.
The
ability
to
guide
cellular
toward
specific
goals
can
be
achieved
by
external
stimuli,
notably
electricity,
light,
ultrasound,
magnetism,
simultaneously
harnessed
through
biomaterial-mediated
responses.
These
triggers
become
focal
points
within
body
due
interactions
biomaterials,
facilitating
a
range
of
pathways:
electrical
signal
transmission,
biochemical
cues,
drug
release,
cell
loading,
modulation
mechanical
stress.
Stimulus-responsive
biomaterials
hold
immense
potential
biomedical
research,
establishing
themselves
as
pivotal
point
interdisciplinary
pursuits.
This
comprehensive
review
systematically
elucidates
prevalent
physical
stimuli
their
corresponding
biomaterial
response
mechanisms.
Moreover,
it
delves
deeply
into
application
domain
biomedicine.
A
balanced
assessment
distinct
stimulation
techniques
provided,
along
discussion
merits
limitations.
aims
shed
light
on
future
trajectory
stimulus-responsive
disease
treatment
outline
prospects
for
development.
poised
spark
novel
concepts
advancing
intelligent,
biomaterials.
Journal of Orthopaedic Translation,
Год журнала:
2025,
Номер
50, С. 111 - 128
Опубликована: Янв. 1, 2025
The
treatment
of
orthopaedic
diseases,
such
as
fractures
and
osteoarthritis,
remains
a
significant
challenge
due
to
the
complex
requirements
for
mechanical
strength
tissue
repair.
Hydrogels
based
on
hyaluronic
acid
methacrylate
(HAMA)
show
promise
engineering
materials
these
conditions.
Hyaluronic
(HA)
is
natural
component
extracellular
matrix,
known
its
good
compatibility.
HAMA-based
hydrogels
can
be
adjusted
through
crosslinking
by
combining
them
with
other
materials.
This
review
provides
an
overview
recent
research
applications
in
diseases.
First,
we
summarize
techniques
preparation
characterization
HAMA
hydrogels.
Next,
offer
detailed
use
treating
conditions
cartilage
injuries,
bone
defects,
meniscus
injuries.
Additionally,
discuss
diseases
related
orthopaedics.
Finally,
point
out
challenges
propose
future
directions
clinical
translation
strong
translational
potential
orthopaedics
their
biocompatibility,
adjustable
properties,
regenerative
capabilities.
With
ongoing
research,
are
well-positioned
applications,
particularly
repair,
osteoarthritis
treatment.
Journal of Controlled Release,
Год журнала:
2023,
Номер
361, С. 280 - 296
Опубликована: Авг. 9, 2023
Extracellular
vesicles
(EVs)
are
small
membrane-bound
released
by
cells.
EVs
emerging
as
a
promising
class
of
therapeutic
entity
that
could
be
adapted
in
formulation
due
to
their
lack
immunogenicity
and
targeting
capabilities.
have
been
shown
similar
regenerative
effects
parental
cells
also
potential
disease
diagnosis.
To
improve
the
EVs,
researchers
developed
various
strategies
for
modifying
them,
including
genetic
engineering
chemical
modifications
which
examined
confer
target
specificity
prevent
rapid
clearance
after
systematic
injection.
Formulation
efforts
focused
on
utilising
hydrogel
nano-formulation
increase
persistence
EV
localisation
specific
tissue
or
organ.
Researchers
used
biomaterials
bioscaffolds
deliver
directly
sites
prolong
release
exposure.
This
review
provides
an
in-depth
examination
material
design
delivery
systems,
highlighting
impact
properties
molecular
interactions
maintenance
stability
function.
The
characteristics
materials
designed
regulate
stability,
rate
biodistribution
described.
Other
aspects
design,
modification
methods
discussed.
aims
offer
understanding
designing
how
they
can
formulated
make
transition
from
laboratory
research
clinical
use.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(33)
Опубликована: Март 3, 2024
Abstract
The
immune
microenvironment
is
critical
for
the
occurrence,
progression,
and
treatment
of
diseases.
Ultrasound
tissue
engineering
technology
utilizes
ultrasound
principles
to
repair,
regenerate,
functionally
reconstruct
biological
tissues.
therapy
a
non‐invasive
modality
that
regulates
maintains
homeostasis
through
various
characteristic
effects.
Ultrasound‐responsive
biomaterials
utilize
properties
or
drug/gene
delivery
regulate
under
stimulation
targeted
purposeful
treatment.
This
article
comprehensively
systematically
reviews
advancements
in
regulating
microenvironment.
First,
changes
at
different
stages
disease
briefly
illustrated.
It
then
reviewed
regulation
by
ultrasound‐responsive
five
types
diseases:
tumor,
cardiovascular
system
diseases,
nervous
musculoskeletal
wound.
Finally,
prospects
summarized.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
Abstract
Inflammatory
responses
play
a
central
role
in
coordinating
biomaterial‐mediated
tissue
regeneration.
However,
precise
modulation
of
dynamic
variations
microenvironmental
inflammation
post‐implantation
remains
challenging.
In
this
study,
the
traditional
β‐tricalcium
phosphate‐based
scaffold
is
remodeled
via
ultrathin
MXene‐Ti
3
C
2
decoration
and
Zn
2+
/Sr
ion‐substitution,
endowing
with
excellent
reactive
oxygen
species‐scavenging
ability,
near‐infrared
responsivity,
enhanced
mechanical
properties.
The
induction
mild
hyperthermia
around
implant
periodic
irradiation
facilitates
spatiotemporal
regulation
inflammatory
cytokines
secreted
by
spectrum
macrophage
phenotypes.
process
initially
amplifies
pro‐inflammatory
response,
then
accelerates
M1‐to‐M2
polarization
transition,
yielding
satisfactory
pattern
osteo‐immunomodulation
during
natural
bone
healing
process.
Later,
sustained
release
ions
gradual
degradation
3D
maintains
favorable
reparative
M2‐dominated
immunological
microenvironment
that
supports
new
mineralization.
Precise
temporal
immunoregulation
intelligent
enhances
regeneration
rat
cranial
defect
model.
This
strategy
paves
way
for
application
materials
to
guide
toward
outcome,
making
clinical
treatment
more
predictable
durable.
findings
also
demonstrate
irradiation‐derived
promising
method
immunomodulation.
