Abstract
Conductive
hydrogels
(CHs)
have
received
significant
attention
for
use
in
wearable
devices
because
they
retain
their
softness
and
flexibility
while
maintaining
high
conductivity.
CHs
are
well
suited
applications
skin‐contact
electronics
biomedical
owing
to
biocompatibility
conformality.
Although
highly
conductive
smart
extensively
researched,
a
detailed
summary
of
the
outstanding
results
is
required
comprehensive
understanding.
In
this
review,
recent
progress
preparation
fabrication
summarized
devices.
Improvements
mechanical,
electrical,
functional
properties
high‐performance
also
discussed.
Furthermore,
examples
innovative
based
on
that
can
be
seamlessly
integrated
into
daily
lives
reviewed.
Molecules,
Год журнала:
2023,
Номер
28(6), С. 2766 - 2766
Опубликована: Март 19, 2023
Over
the
last
decade,
efforts
have
been
oriented
toward
development
of
suitable
gels
for
3D
printing,
with
controlled
morphology
and
shear-thinning
behavior
in
well-defined
conditions.
As
a
multidisciplinary
approach
to
fabrication
complex
biomaterials,
bioprinting
combines
cells
biocompatible
materials,
which
are
subsequently
printed
specific
shapes
generate
structures
regenerative
medicine
or
tissue
engineering.
A
major
interest
is
devoted
printing
biomimetic
materials
structural
fidelity
after
their
fabrication.
Among
some
requirements
imposed
bioinks,
such
as
biocompatibility,
nontoxicity,
possibility
be
sterilized,
nondamaging
processability
represents
critical
issue
stability
functioning
constructs.
The
challenges
field
printable
mimic
at
different
length
scales
existing
nature
reproduce
functions
biological
systems.
Thus,
careful
investigation
rheological
characteristics
allows
fine-tuning
material
properties
that
manufactured
targeted
applications.
fluid-like
solid-like
conditions
similar
those
encountered
additive
manufacturing
can
monitored
through
viscoelastic
parameters
determined
shear
network
strength,
shear-thinning,
yield
point,
thixotropy
govern
bioprintability.
An
assessment
these
features
provides
significant
insights
design
characterization
gels.
This
review
focuses
on
bioinspired
survey
cutting-edge
research
developing
manufacturing.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(36)
Опубликована: Фев. 28, 2024
Abstract
Chronic
diabetic
wound
repair
is
a
global
medical
challenge.
Developing
hydrogel
dressing
to
effectively
promote
angiogenesis
and
detect
state
in
management
an
unmet
requirement.
Herein,
facile
efficient
strategy
prepare
self‐healing
with
enhanced
real‐time
monitoring
for
wounds
presented,
by
cross‐linking
carboxymethyl
cellulose
(CMC)
precoordinated
europium‐ethylenediaminetetraacetic
acid
(Eu‐EDTA)
complexes.
Benefiting
from
the
dynamic
reversible
coordination
interaction
formation,
exhibits
remarkable
injectability
properties,
thus
forming
coverage
irregular
deep
minimally
invasive
procedures.
Furthermore,
fluorescence
of
changes
linearly
pH
value
range
4.5–7.5
enables
measurement
monitor
state.
More
importantly,
can
proliferation
migration
endothelial
cells
enhance
tube
formation
ability,
demonstrating
great
capacity
tissue
remodeling.
The
vivo
experiments
manifested
that
upregulating
expression
angiogenesis‐related
factors
downregulating
matrix
metalloproteinase‐9
(MMP‐9),
contributing
granulation
collagen
deposition,
repair.
This
work
provide
promising
diagnosis
therapy
clinical
wounds.
Bioactive Materials,
Год журнала:
2023,
Номер
29, С. 98 - 115
Опубликована: Июль 5, 2023
Tumor
microenvironment
(TME)
plays
an
important
role
in
the
tumorigenesis,
proliferation,
invasion
and
metastasis.
Thereby
developing
synergistic
anticancer
strategies
with
multiple
mechanisms
are
urgent.
Copper
is
widely
used
treatment
of
tumor
chemodynamic
therapy
(CDT)
due
to
its
excellent
laser-mediated
photo-Fenton-like
reaction.
Additionally,
copper
can
induce
cell
death
through
cuproptosis,
which
a
new
modality
different
from
known
has
great
promise
treatment.
Herein,
we
report
natural
small
molecules
carrier-free
injectable
hydrogel
(NCTD
Gel)
consisted
Cu2+-mediated
self-assembled
glycyrrhizic
acid
(GA)
norcantharidin
(NCTD),
mainly
governed
by
coordination
hydrogen
bonds.
Under
808
nm
laser
irradiation,
NCTD
Gel
produce
reactive
oxygen
species
(ROS),
consume
glutathione
(GSH)
overcome
hypoxia
TME,
leading
synergistically
regulate
TME
via
apoptosis,
cuproptosis
anti-inflammation.
In
addition,
Gel's
CDT
display
high
selectivity
good
biocompatibility
as
it
relies
on
weak
acidity
H2O2
overexpression
TME.
Notably,
components
originated
clinical
agents
preparation
process
easy,
green
economical,
without
any
excipients.
This
study
provides
antitumor
strategy,
prospect
industrial
production
transformation.
ACS Nano,
Год журнала:
2023,
Номер
17(4), С. 3847 - 3864
Опубликована: Фев. 13, 2023
Postoperative
abdominal
adhesions
are
a
common
problem
after
surgery
and
can
produce
serious
complications.
Current
antiadhesive
strategies
focus
mostly
on
physical
barriers
unsatisfactory
inefficient.
In
this
study,
we
designed
synthesized
advanced
injectable
cream-like
hydrogels
with
multiple
functionalities,
including
rapid
gelation,
self-healing,
antioxidation,
anti-inflammation,
anti-cell
adhesion.
The
multifunctional
were
facilely
formed
by
the
conjugation
reaction
of
epigallocatechin-3-gallate
(EGCG)
hyaluronic
acid
(HA)-based
microgels
poly(vinyl
alcohol)
(PVA)
based
dynamic
boronic
ester
bond.
physicochemical
properties
antioxidative
anti-inflammatory
activities
systematically
characterized.
A
mouse
cecum–abdominal
wall
adhesion
model
was
implemented
to
investigate
efficacy
our
microgel-based
in
preventing
postoperative
adhesions.
hydrogels,
high
molecular
weight
HA,
significantly
decreased
inflammation,
oxidative
stress,
fibrosis
reduced
formation,
compared
commercial
Seprafilm
group
or
Injury-only
group.
Label-free
quantitative
proteomics
analysis
demonstrated
that
S100A8
S100A9
expressions
associated
formation;
microgel-containing
inhibited
these
expressions.
multifunctionality
formation
intra-abdominal
murine
model,
demonstrating
promise
for
clinical
applications.
ACS Omega,
Год журнала:
2023,
Номер
8(9), С. 8172 - 8189
Опубликована: Фев. 20, 2023
Wound
healing
is
a
complex
and
dynamic
physiological
process
consisting
of
series
cellular
molecular
events
that
initiate
immediately
after
tissue
lesion,
to
reconstruct
the
skin
layer.
It
indubitable
patients
with
chronic
wounds,
severely
infected
or
any
metabolic
disorder
wound
microenvironment
always
endure
severe
pain
discomfort
affect
their
quality
life.
essential
treat
wounds
for
conserving
physical
as
well
mental
well-being
affected
convalescing
improve
For
supporting
augmenting
process,
selection
pertinent
dressing
essential.
A
substantial
reduction
in
duration,
disability,
associated
cost,
risk
recurrent
infections
can
be
achieved
via
engineering
dressings.
Hydrogels
play
leading
role
path
ideal
Hydrogels,
comprising
water
large
extent,
providing
moist
environment,
being
comfortable
patients,
having
biocompatible
biodegradable
properties,
have
found
success
suitable
dressings
market.
The
exploitation
hydrogels
increasing
perpetually
substantiation
broader
therapeutic
actions
owing
resemblance
dermal
tissues,
capability
stimulate
partial
regeneration,
ability
incorporate
moieties
promoting
healing.
This
review
entails
properties
hydrogel
healing,
types
hydrogels,
cross-linking
mechanisms,
design
considerations,
formulation
strategies
engineering.
Various
categories
fabricated
recently
are
discussed
based
on
gel
network
composition,
degradability,
chemical
which
provide
an
outlook
regarding
importance
tailoring
physicochemical
hydrogels.
examples
marketed
also
incorporated
along
future
perspectives
challenges
them.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2023,
Номер
11
Опубликована: Фев. 22, 2023
Hydrogels
are
widely
used
biomaterials
in
the
delivery
of
therapeutic
agents,
including
drugs,
genes,
proteins,
etc.,
as
well
tissue
engineering,
due
to
obvious
properties
such
biocompatibility
and
their
similarity
natural
body
tissues.
Some
these
substances
have
feature
injectability,
which
means
that
substance
is
injected
into
desired
place
solution
state
then
turns
gel,
makes
it
possible
administer
them
from
a
way
with
minimal
amount
invasion
eliminate
need
for
surgery
implant
pre-formed
materials.
Gelation
can
be
caused
by
stimulus
and/or
spontaneously.
Suppose
this
induces
effect
one
or
many
stimuli.
In
case,
material
question
called
stimuli-responsive
because
responds
surrounding
conditions.
context,
we
introduce
different
stimuli
cause
gelation
investigate
mechanisms
transformation
gel
them.
Also,
study
special
structures,
nano
gels
nanocomposite
gels.
