Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(32), P. 7692 - 7759
Published: Jan. 1, 2024
Tissue engineering has emerged as a remarkable field aiming to repair or replace damaged tissues through the use of biomimetic constructs.
Language: Английский
Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 257, P. 110687 - 110687
Published: March 21, 2023
Language: Английский
Citations
56
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)
Published: Feb. 28, 2024
Abstract Chronic diabetic wound repair is a global medical challenge. Developing hydrogel dressing to effectively promote angiogenesis and detect state in management an unmet requirement. Herein, facile efficient strategy prepare self‐healing with enhanced real‐time monitoring for wounds presented, by cross‐linking carboxymethyl cellulose (CMC) precoordinated europium‐ethylenediaminetetraacetic acid (Eu‐EDTA) complexes. Benefiting from the dynamic reversible coordination interaction formation, exhibits remarkable injectability properties, thus forming coverage irregular deep minimally invasive procedures. Furthermore, fluorescence of changes linearly pH value range 4.5–7.5 enables measurement monitor state. More importantly, can proliferation migration endothelial cells enhance tube formation ability, demonstrating great capacity tissue remodeling. The vivo experiments manifested that upregulating expression angiogenesis‐related factors downregulating matrix metalloproteinase‐9 (MMP‐9), contributing granulation collagen deposition, repair. This work provide promising diagnosis therapy clinical wounds.
Language: Английский
Citations
54
ACS Nano, Journal Year: 2023, Volume and Issue: 17(4), P. 3847 - 3864
Published: Feb. 13, 2023
Postoperative abdominal adhesions are a common problem after surgery and can produce serious complications. Current antiadhesive strategies focus mostly on physical barriers unsatisfactory inefficient. In this study, we designed synthesized advanced injectable cream-like hydrogels with multiple functionalities, including rapid gelation, self-healing, antioxidation, anti-inflammation, anti-cell adhesion. The multifunctional were facilely formed by the conjugation reaction of epigallocatechin-3-gallate (EGCG) hyaluronic acid (HA)-based microgels poly(vinyl alcohol) (PVA) based dynamic boronic ester bond. physicochemical properties antioxidative anti-inflammatory activities systematically characterized. A mouse cecum–abdominal wall adhesion model was implemented to investigate efficacy our microgel-based in preventing postoperative adhesions. hydrogels, high molecular weight HA, significantly decreased inflammation, oxidative stress, fibrosis reduced formation, compared commercial Seprafilm group or Injury-only group. Label-free quantitative proteomics analysis demonstrated that S100A8 S100A9 expressions associated formation; microgel-containing inhibited these expressions. multifunctionality formation intra-abdominal murine model, demonstrating promise for clinical applications.
Language: Английский
Citations
53
Bioactive Materials, Journal Year: 2023, Volume and Issue: 29, P. 98 - 115
Published: July 5, 2023
Tumor microenvironment (TME) plays an important role in the tumorigenesis, proliferation, invasion and metastasis. Thereby developing synergistic anticancer strategies with multiple mechanisms are urgent. Copper is widely used treatment of tumor chemodynamic therapy (CDT) due to its excellent laser-mediated photo-Fenton-like reaction. Additionally, copper can induce cell death through cuproptosis, which a new modality different from known has great promise treatment. Herein, we report natural small molecules carrier-free injectable hydrogel (NCTD Gel) consisted Cu2+-mediated self-assembled glycyrrhizic acid (GA) norcantharidin (NCTD), mainly governed by coordination hydrogen bonds. Under 808 nm laser irradiation, NCTD Gel produce reactive oxygen species (ROS), consume glutathione (GSH) overcome hypoxia TME, leading synergistically regulate TME via apoptosis, cuproptosis anti-inflammation. In addition, Gel's CDT display high selectivity good biocompatibility as it relies on weak acidity H2O2 overexpression TME. Notably, components originated clinical agents preparation process easy, green economical, without any excipients. This study provides antitumor strategy, prospect industrial production transformation.
Language: Английский
Citations
53
ACS Omega, Journal Year: 2023, Volume and Issue: 8(9), P. 8172 - 8189
Published: Feb. 20, 2023
Wound healing is a complex and dynamic physiological process consisting of series cellular molecular events that initiate immediately after tissue lesion, to reconstruct the skin layer. It indubitable patients with chronic wounds, severely infected or any metabolic disorder wound microenvironment always endure severe pain discomfort affect their quality life. essential treat wounds for conserving physical as well mental well-being affected convalescing improve For supporting augmenting process, selection pertinent dressing essential. A substantial reduction in duration, disability, associated cost, risk recurrent infections can be achieved via engineering dressings. Hydrogels play leading role path ideal Hydrogels, comprising water large extent, providing moist environment, being comfortable patients, having biocompatible biodegradable properties, have found success suitable dressings market. The exploitation hydrogels increasing perpetually substantiation broader therapeutic actions owing resemblance dermal tissues, capability stimulate partial regeneration, ability incorporate moieties promoting healing. This review entails properties hydrogel healing, types hydrogels, cross-linking mechanisms, design considerations, formulation strategies engineering. Various categories fabricated recently are discussed based on gel network composition, degradability, chemical which provide an outlook regarding importance tailoring physicochemical hydrogels. examples marketed also incorporated along future perspectives challenges them.
Language: Английский
Citations
49
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: Feb. 22, 2023
Hydrogels are widely used biomaterials in the delivery of therapeutic agents, including drugs, genes, proteins, etc., as well tissue engineering, due to obvious properties such biocompatibility and their similarity natural body tissues. Some these substances have feature injectability, which means that substance is injected into desired place solution state then turns gel, makes it possible administer them from a way with minimal amount invasion eliminate need for surgery implant pre-formed materials. Gelation can be caused by stimulus and/or spontaneously. Suppose this induces effect one or many stimuli. In case, material question called stimuli-responsive because responds surrounding conditions. context, we introduce different stimuli cause gelation investigate mechanisms transformation gel them. Also, study special structures, nano gels nanocomposite gels.
Language: Английский
Citations
48
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: unknown, P. 121812 - 121812
Published: Jan. 1, 2024
Language: Английский
Citations
47
Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 319, P. 102982 - 102982
Published: Aug. 13, 2023
Language: Английский
Citations
42
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215790 - 215790
Published: March 20, 2024
Language: Английский
Citations
36
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105601 - 105601
Published: March 18, 2024
Language: Английский
Citations
34