Advanced Materials,
Год журнала:
2024,
Номер
36(33)
Опубликована: Июнь 6, 2024
The
growing
aging
population,
with
its
associated
chronic
diseases,
underscores
the
urgency
for
effective
tissue
regeneration
strategies.
Biomaterials
play
a
pivotal
role
in
realm
of
reconstruction
and
regeneration,
distinct
shift
toward
minimally
invasive
(MI)
treatments.
This
transition,
fueled
by
engineered
biomaterials,
steers
away
from
surgical
procedures
to
embrace
approaches
offering
reduced
trauma,
accelerated
recovery,
cost-effectiveness.
In
MI
repair
cargo
delivery,
various
techniques
are
explored.
While
situ
polymerization
is
prominent,
it
not
without
challenges.
narrative
review
explores
diverse
fabrication
methods,
biofunctionalization
injectable
pre-formed
scaffolds,
focusing
on
their
unique
advantages.
exhibiting
compressibility,
controlled
injection,
maintained
mechanical
integrity,
emerge
as
promising
alternative
solutions
conclusion
this
emphasizes
importance
interdisciplinary
design
facilitated
synergizing
fields
materials
science,
advanced
3D
biomanufacturing,
mechanobiological
studies,
innovative
regeneration.
ACS Nano,
Год журнала:
2024,
Номер
18(34), С. 22780 - 22792
Опубликована: Авг. 14, 2024
Hydrogel-based
depots
typically
tend
to
remain
where
injected
and
have
excellent
biocompatibility
but
are
relatively
poor
at
controlling
drug
release.
Nanoparticles
(NPs)
the
opposite
properties.
The
smaller
NPs
are,
more
likely
they
leave
site
of
injection.
Their
is
variable
depending
on
material
can
be
poor.
However,
good
In
these
other
properties,
combining
hydrogels
leverage
their
advantages
negate
disadvantages.
This
review
highlights
rationale
for
hybrid
NP-hydrogel
systems
in
delivery,
basic
methods
producing
them,
examples
two
addressed
specific
problems.
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Окт. 11, 2024
Nanoparticulate
delivery
systems
have
been
attracting
attention
in
pharmaceutical
sciences
for
enhanced
drug
bioavailability
and
targeted
delivery.
Specifically,
these
can
enhance
the
solubility
of
poorly
water-soluble
drugs,
protect
therapeutic
agents
from
degradation,
prolong
circulation
time
body,
control
release,
facilitate
precise
targeting
drugs
to
specific
tissues
or
cells.
However,
once
administered
into
nanoparticles
often
encounter
significant
challenges
that
affect
their
efficacy
safety,
such
as
issues
with
stability,
biocompatibility,
targeting.
The
surface
properties
are
one
most
important
features
they
greatly
influence
interactions
between
themselves
biological
targets.
Key
characteristics,
charge,
hydrophobicity,
presence
functional
groups,
determine
how
behave
environments,
thereby
influencing
cellular
uptake,
ability
avoid
immune
clearance.
Modification
nanoparticle
has
shown
be
an
effective
approach
modulate
physicochemical
nanoparticles,
achieving
desired
vivo
.
This
review
aims
summarize
recent
advances
decoration
emphasis
on
improved
colloidal
reduced
toxicity,
future
perspectives
modification
approaches
also
discussed.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(18), С. 9059 - 9132
Опубликована: Янв. 1, 2024
Nanodrugs,
which
utilise
nanomaterials
in
disease
prevention
and
therapy,
have
attracted
considerable
interest
since
their
initial
conceptualisation
the
1990s.
Substantial
efforts
been
made
to
develop
nanodrugs
for
overcoming
limitations
of
conventional
drugs,
such
as
low
targeting
efficacy,
high
dosage
toxicity,
potential
drug
resistance.
Despite
significant
progress
that
has
nanodrug
discovery,
precise
design
or
screening
with
desired
biomedical
functions
prior
experimentation
remains
a
challenge.
This
is
particularly
case
regard
personalised
precision
nanodrugs,
require
simultaneous
optimisation
structures,
compositions,
surface
functionalities
nanodrugs.
The
development
powerful
computer
clusters
algorithms
it
possible
overcome
this
challenge
through
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Despite
the
significant
potential
of
short
hairpin
RNA
(shRNA)‐mediated
gene
therapy
for
various
diseases,
clinical
success
cancer
treatment
remains
poor,
partly
because
low
selectivity
and
efficiency.
In
this
study,
an
mRNA‐initiated
autonomous
multi‐shRNA
nanofactory
(RNF@CM)
is
designed
in
vivo
amplification
imaging
precise
treatment.
The
RNF@CM
consists
a
gold
nanoparticle
core,
interlayer
two
types
three‐stranded
DNA/RNA
hybrid
probes,
one
which
bound
to
aptamer‐inhibited
DNA
polymerases,
outer
layer
cell
membrane.
After
specific
delivery
into
target
cells,
intracellular
tumour‐related
mRNA
can
initiate
with
circular
strand‐displacement
polymerisation
reaction,
resulting
release
significantly
amplified
fluorescence
continuous
production
three
shRNAs.
effectively
distinguished
cells
from
normal
exclusively
produced
multiple
shRNAs
response
accurately
diagnosed
tumours
vivo,
inhibited
tumour
growth
negligible
toxicity,
expanding
toolbox
on‐demand
precision
theranostics.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 24, 2025
The
liver
performs
crucial
roles
in
energy
metabolism,
detoxification,
and
immune
regulation.
Hepatic
diseases,
including
hepatitis,
fibrosis,
cancer,
have
posed
a
significant
threat
to
global
health,
emphasizing
the
critical
need
for
development
of
novel
effective
treatment
approaches.
Nanotechnology,
an
emerging
technology,
has
been
extensively
researched
medicine.
Among
many
types
nanomaterials,
polymeric
nanoparticles
(NPs)
are
widely
used
drug
delivery
systems.
Compared
traditional
therapies,
they
offer
advantages
disease
by
improving
outcomes
reducing
side
effects.
This
review
introduced
discussed
application
natural
polymers
synthetic
their
management.
Furthermore,
this
paper
reviewed
-mainly
chitosan
(CS),
hyaluronic
acid
(HA),
polyethylene
glycol
(PEG)
poly
(lactic-co-glycolic
acid)
(PLGA)-in
treatment,
focusing
on
use
various
systems
pure
bioactive
compounds
origin,
drugs,
nucleic
acids,
peptides,
others.
Finally,
challenges
future
perspectives
NPs
were
provide
guidance
further
research
directions,
with
aim
promoting
clinical
nanotherapeutics
treating
hepatic
diseases.
Polymer Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
modular
approach
to
install
functional
chain-end
groups
through
a
redox-responsive
disulfide
linkage
is
utilized
fabricate
targeted
delivery
system
using
self-assembly.
