Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 248, С. 114458 - 114458
Опубликована: Дек. 16, 2024
Язык: Английский
Progress in Polymer Science, Год журнала: 2025, Номер unknown, С. 101929 - 101929
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160591 - 160591
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Regenerative Biomaterials, Год журнала: 2025, Номер 12
Опубликована: Янв. 1, 2025
Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(3), С. 170 - 170
Опубликована: Фев. 26, 2025
Cancer is a global health concern. Various therapeutic approaches, including chemotherapy, photodynamic therapy, and immunotherapy, have been developed for cancer treatment. Silica nanoparticles, quantum dots, metal–organic framework (MOF)-based nanomedicines gained interest in therapy because of their selective accumulation tumors via the enhanced permeability retention (EPR) effect. However, bare nanoparticles face challenges poor biocompatibility, low stability, limited drug-loading capacity, rapid clearance by reticuloendothelial system (RES). Gels with unique three-dimensional network structures formed through various interactions such as covalent hydrogen bonds are emerging promising materials addressing these challenges. Gel hybridization enhances facilitates controlled drug release, confers cancer-targeting abilities to nanoparticles. This review discusses gel–nanoparticle hybrid systems treatment past five years analyzes roles gels systems.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Март 5, 2025
The incidence and mortality rates of digestive tract tumors, especially gastric colorectal cancers, are high worldwide. Owing to their unique advantages, such as efficient drug loading, safety, targeting properties, nanoparticles (NPs) have demonstrated great potential in the treatment gastrointestinal tumors. However, practical application is limited by several factors, costs, few clinical trials, long approval periods. In this review, we summarize three types immunotherapeutic nanomaterial drugs for tumors: organic, inorganic, hybrid nanomaterials. This article also discusses current status research development field advantages each type material provide theoretical references developing new advancing research.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141787 - 141787
Опубликована: Март 6, 2025
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2024, Номер unknown
Опубликована: Дек. 9, 2024
Viral nanoparticles (VNPs) have emerged as crucial tools in the field of biomedicine. Leveraging their biological and physicochemical properties, VNPs exhibit significant advantages prevention, diagnosis, treatment human diseases. Through techniques such chemical bioconjugation, infusion, genetic engineering, encapsulation, these been endowed with multifunctional capabilities, including display functional peptides or proteins, encapsulation therapeutic drugs inorganic particles, integration imaging agents, conjugation bioactive molecules. This review provides an in-depth analysis biomedicine, elucidating diverse types, distinctive features, production methods, complex design principles behind VNPs. It highlights recent innovative research various applications, covering roles imaging, drug delivery, therapeutics, gene vaccines, immunotherapy, tissue regeneration. Additionally, assessment safety biocompatibility discusses challenges future opportunities field, underscoring vast potential evolving nature VNP research.
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2024, Номер 29(19), С. 4666 - 4666
Опубликована: Сен. 30, 2024
Self-healing, stretchable, and moldable hydrogels have a great potential application in tissue engineering soft robotics. Despite success reported hydrogels, it is still challenge to construct the with an ultrafast self-healing performance. Herein, composite (PBLH) self-healing, properties were successfully constructed by poly (vinyl alcohol) (PVA), borate (B), ε-poly-l-lysine (EPL), hyaluronic acid (HA) based on efficient one-pot method. Fourier transform infrared spectroscopy, X-ray diffraction, rheological measurements confirmed formation of dynamic network among PVA, B, EPL, HA through cross-linking bonds, electrostatic interaction, hydrogen bonding. Having fabricated structure, damage gap can heal within 1 min, presenting excellent ability. Simultaneously, be molded into various shapes, length stretched 15 times their original length. In addition, exhibited antibacterial property against Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). Our results illustrated that not only retain advantages traditional but also possess outstanding stretchable properties, prospective candidate for constructing biomedical materials.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2024, Номер 29, С. 101295 - 101295
Опубликована: Окт. 10, 2024
Ischemia-reperfusion injury (IRI) commonly occurs in clinical settings, particularly medical practices such as organ transplantation, cardiopulmonary resuscitation, and recovery from acute trauma, posing substantial challenges therapies. Current systemic therapies for IRI are limited by poor drug targeting, short efficacy, significant side effects. Owing to their exceptional biocompatibility, biodegradability, excellent mechanical properties, targeting capabilities, controlled release potential, properties mimicking the extracellular matrix (ECM), hydrogels not only serve superior platforms therapeutic substance delivery retention, but also facilitate bioenvironment cultivation cell recruitment, demonstrating potential treatment. This review explores pathological processes of discusses roles outcomes various hydrogel systems. By categorizing systems into depots delivering agents, scaffolds encapsulating mesenchymal stem cells (MSCs), ECM-mimicking hydrogels, this article emphasizes selection polymers substances, details special crosslinking mechanisms physicochemical well summarizes application Furthermore, it evaluates limitations current treatments suggests directions future applications.
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 248, С. 114458 - 114458
Опубликована: Дек. 16, 2024
Язык: Английский
Процитировано
0