Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Дек. 30, 2024
Oxidative modifications can disrupt protein folds and functions, are strongly associated with human aging diseases. Conventional oxidation pathways typically involve the free diffusion of reactive oxygen species (ROS), which primarily attack surface. Yet, it remains unclear whether how internal capable trapping (O
Язык: Английский
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Abstract X‐ray induced photodynamic therapy (X‐PDT) leverages penetrating to generate singlet oxygen ( 1 O 2 ) for treating deep‐seated tumors. However, conventional X‐PDT typically relies on heavy metal inorganic scintillators and organic photosensitizers produce , which presents challenges related toxicity energy conversion efficiency. In this study, highly biocompatible phosphorescent nanoscintillators based hydrogen‐bonded frameworks (HOF) are designed engineered, termed BPT‐HOF@PEG, enhance in hepatocellular carcinoma (HCC) treatment. BPT‐HOF@PEG functions simultaneously as both scintillator photosensitizer, effectively absorbing transferring abundant . Both vitro vivo investigations demonstrate that internalized efficiently produces significant quantities of upon irradiation. Additionally, exposure directly inflicts DNA damage, the synergistic effects these mechanisms result pronounced cell death substantial tumor growth inhibition, with a inhibition rate up 90.4% assessments. RNA sequencing analyses reveal induces apoptosis Hepa1‐6 cells while inhibiting proliferation, culminating death. Therefore, work highlights considerable potential efficient HOF nanoscintillators‐based promising therapeutic approach HCC, providing effective alternative negligible patients unresectable
Язык: Английский
Процитировано
2
Pharmaceuticals, Год журнала: 2024, Номер 17(10), С. 1274 - 1274
Опубликована: Сен. 26, 2024
Photodynamic therapy (PDT) is a therapeutic modality that depends on the interaction of light, photosensitizers, and oxygen. The photon absorption energy transfer process can lead to Type II photochemical reaction photosensitizer production singlet oxygen (
Язык: Английский
Процитировано
4
Angewandte Chemie International Edition, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).
Язык: Английский
Процитировано
0
Angewandte Chemie, Год журнала: 2025, Номер unknown
Опубликована: Янв. 13, 2025
Abstract Photoactivatable metal complexes offer the prospect of novel drugs with low side effects and new mechanisms action to combat resistance current therapy. We highlight recent progress in design platinum, ruthenium, iridium, gold other transition complexes, especially for applications as anticancer anti‐infective agents. In particular, understanding excited state chemistry related identification bioactive species (excited metallomics/pharmacophores) is important. metallodrugs are classified here photocatalysts, photorelease agents ligand‐activated Their activation wavelengths, cellular action, experimental theoretical metallomics states photoproducts discussed explore strategies investigation photoactivatable metallodrugs. These have potential clinical Photodynamic Therapy (PDT), Photoactivated Chemotherapy (PACT) Photothermal (PTT).
Язык: Английский
Процитировано
0
ACS Omega, Год журнала: 2025, Номер unknown
Опубликована: Янв. 26, 2025
Molecular fluorescence is typically reduced or "quenched" by dissolved oxygen present in solutions. Quenching mechanisms are broadly categorized as dynamic quenching, and static quenching. Dynamic quenching involves collisions between the fluorophore. Static occurs when fluorophore forms a nonfluorescent complex with oxygen. In previous study, of naphthalene showed evidence although mechanism was not known. The earlier work limited to low concentrations (∼2 mM) cyclohexane, leading relatively large uncertainties value constant. up ∼50 mM were used, resulting more accurate determination Absorption spectra obtained at higher revealed spectrum new species, which we interpret that naphthalene-oxygen charge-transfer complex. binding energy estimated compared benzene-oxygen method described herein, equilibrium (or association) constant for assumed be constant, determined from graphs relative intensities vs concentration using Stern-Volmer formalism. values molecular absorption coefficients absorbance data. This differs commonly used determine product coefficient. latter can lead substantial errors both these quantities if free molecule overlap significantly.
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2025, Номер 12(2), С. 118 - 118
Опубликована: Янв. 27, 2025
A total of 75% the oxygen humans inhale is exhaled without being utilized. To help organisms better utilize in exercise training, we designed singlet energy generator (SOEG), a device that converts ambient air into energy-rich oxygen. The SOEG comprises an LED light source, photosensitizer kit, and pump. Based on principle photosynthesis, activates to produce excited-state under irradiation light, which releases about 94 kJ/mol (SOE) after relaxation process. After comparing data from 14 volunteers, found inhaling SOE during significantly reduces consumption running, decreases uptake, improves running efficiency. At same time, effectively lowers blood lactate levels utilization, indicating may enhance endurance efficiency exercise.
Язык: Английский
Процитировано
0
Food Chemistry, Год журнала: 2025, Номер 477, С. 143481 - 143481
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Iridium(III) complexes have been recognized as promising candidates for two-photon sensitized photodynamic therapy (PDT). In this context, we report on the study of two complexes: a monomer (IrL1) and dimer (Ir2L2). Both possess 2-phenylpyridine cyclometallating ligands pyridylbenzimidazole derivative an ancillary ligand. dimer, Ir(III) centers are connected by non-conjugated bridged bis(pyridylbenzimidazole). We compare photophysical properties these complexes. display phosphorescent emission in orange-red part visible spectrum, with emissions centered at 610 nm IrL1 625 Ir2L2, both exhibiting quantum yields ∼24%. However, Ir2L2 proves to be much brighter than monomer, making four times IrL1. This trend is consistent under excitation (TPE), singlet oxygen generation yields, displaying figure merit (σTPA × ΦΔ) 40, compared only 5 monomer. generate intracellular ROS exhibit strong phototoxicity upon blue light activation (λ = 420 nm), achieving submicromolar IC50 values HT29 A549 cell lines after 24 h incubation. Moreover, TPE 800 also induce cancer death.
Язык: Английский
Процитировано
0
Chemical Science, Год журнала: 2024, Номер 15(36), С. 14746 - 14756
Опубликована: Янв. 1, 2024
Full photophysical picture and thermally activated ISC was revealed for rhodacyclopentadienes by fs-spectroscopy Marcus analysis, while potential application on 1 O 2 sensitizing explored.
Язык: Английский
Процитировано
1
RSC Advances, Год журнала: 2024, Номер 14(39), С. 28783 - 28790
Опубликована: Янв. 1, 2024
An extra adenine mononucleotide part in flavin dinucleotide (FAD), compared with (FMN), significantly affects FAD's conformational properties and efficiency of singlet oxygen production dependence on pH.
Язык: Английский
Процитировано
1