Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line DOI
Deepika Saini, Pankaj Kumar Chaudhary, Ganesh Kumar Verma

et al.

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: 108, P. 106082 - 106082

Published: May 23, 2025

Language: Английский

Activation of lysosomal iron triggers ferroptosis in cancer DOI Creative Commons
Tatiana Cañeque, Leeroy Baron, Sebastian Müller

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Iron catalyses the oxidation of lipids in biological membranes and promotes a form cell death called ferroptosis1. Defining where this chemistry occurs can inform design drugs capable inducing or inhibiting ferroptosis various disease-relevant settings. Genetic approaches have revealed suppressors ferroptosis2-4; by contrast, small molecules provide spatiotemporal control at work5. Here we show that inhibitor liproxstatin-1 exerts cytoprotective effects inactivating iron lysosomes. We also inducer RSL3 initiates membrane lipid designed small-molecule activator lysosomal iron-fentomycin-1-to induce oxidative degradation phospholipids ultimately ferroptosis. Fentomycin-1 is able to kill iron-rich CD44high primary sarcoma pancreatic ductal adenocarcinoma cells, which promote metastasis fuel drug tolerance. In such regulates adaptation6,7 while conferring vulnerability ferroptosis8,9. Sarcoma cells exposed sublethal doses fentomycin-1 acquire ferroptosis-resistant state characterized downregulation mesenchymal markers activation membrane-damage response. This phospholipid degrader eradicate drug-tolerant persister cancer vitro reduces intranodal tumour growth mouse model breast metastasis. Together, these results reactivity confers therapeutic benefits, establish as druggable target highlight value targeting states10.

Language: Английский

Citations

3
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis DOI

Wenqian Zheng,

Yang Liu, Jinru Liu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137337 - 137337

Published: March 1, 2025

Language: Английский

Citations

1
Copper-based nanoplatforms and their role in cancer therapy DOI
José I. García-Peiro, Javier Bonet-Aletá,

José L. Hueso

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216542 - 216542

Published: March 13, 2025

Language: Английский

Citations

0
Molecular mechanistic approach to reveal decitabine's effect on DNMT gene modulation and its inhibitory role in heavy metal-induced proliferation in urinary bladder cancer cell line DOI
Deepika Saini, Pankaj Kumar Chaudhary, Ganesh Kumar Verma

et al.

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: 108, P. 106082 - 106082

Published: May 23, 2025

Language: Английский

Citations

0