Tissue accumulation of microplastics and potential health risks in human

The Science of The Total Environment, Год журнала: 2024, Номер 915, С. 170004 - 170004

Опубликована: Янв. 21, 2024

Язык: Английский

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Impact of Plastic Particles on the Horizontal Transfer of Antibiotic Resistance Genes to Bacterium: Dependent on Particle Sizes and Antibiotic Resistance Gene Vector Replication Capacities

Environmental Science & Technology, Год журнала: 2022, Номер 56(21), С. 14948 - 14959

Опубликована: Май 3, 2022

Plastic particles impact the propagation of antibiotic resistance genes (ARGs) in environmental media, and their perturbation on horizontal gene transfer (HGT) ARGs is recognized as a critical influencing mechanism. However, studies concerning influence mechanisms plastic HGT were limited, particularly for effect particle sizes ARG vector-associated mechanisms. This study explored polystyrene (PS) with 75, 90, 100, 1000, 10000 nm (via transformation) mediated by pUC19, pSTV29, pBR322 plasmids into Escherichia coli cells. PS ≤100 impacted transformation ARGs, but large (1000 nm) showed no obvious effects. Effects three vastly distinct. For pUC19 high replication capacities, was monotonously promoted. pSTV29 low suppressing effects observed. attributed to two competing The enhancing mechanism that direct interaction membrane lipids indirect associated bacterial oxidative stress response induced pore formation cell increased permeability, thus plasmid entrance. inhibiting interfered inside E. coli, decreasing tranformation. deepened our understanding dissemination contamination.

Язык: Английский

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Characterization and regulation of microplastic pollution for protecting planetary and human health

Environmental Pollution, Год журнала: 2022, Номер 315, С. 120442 - 120442

Опубликована: Окт. 19, 2022

Язык: Английский

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Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation

The Science of The Total Environment, Год журнала: 2022, Номер 838, С. 155937 - 155937

Опубликована: Май 16, 2022

Microplastics (MPs) as emerging contaminants have become a global environmental problem. However, studies on the effects of MPs metabolic diseases remain limited. Here, we evaluated polystyrene (PS), one most prominent types MPs, insulin sensitivity in mice fed with normal chow diet (NCD) or high-fat (HFD), and explained underlying mechanisms. Mice NCD HFD both showed resistance (IR) after PS exposure accompanied by increased plasma lipopolysaccharide pro-inflammatory cytokines such tumor necrosis factor-α interleukin-1β. Exposure to also resulted significant decrease richness diversity gut microbiota, particularly an increase relative abundance Gram-negative bacteria Prevotellaceae Enterobacteriaceae. Additionally, small particle size (5 μm) accumulated liver, kidneys blood vessels mice. Further analyses inhibition signaling pathway liver exposed mice, IRS1 decreased expression PI3K. Hence, mechanism induce IR might be mediated through regulating microbiota accumulation tissues, stimulating inflammation inhibiting pathway. In conclusion, potential contaminant that causes associated IR.

Язык: Английский

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Microplastics in human samples: Recent advances, hot-spots, and analytical challenges

TrAC Trends in Analytical Chemistry, Год журнала: 2023, Номер 161, С. 117016 - 117016

Опубликована: Март 11, 2023

Язык: Английский

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