Environmental Health,
Год журнала:
2023,
Номер
22(1)
Опубликована: Сен. 2, 2023
Abstract
Background
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
synthetic
chemicals
found
in
drinking
water
consumer
products,
resulting
ubiquitous
human
exposure.
PFAS
have
been
linked
to
endocrine
disruption
altered
weight
gain
across
the
lifespan.
A
limited
inconsistent
body
of
research
suggests
may
impact
gestational
(GWG)
postpartum
mass
index
(BMI),
which
important
predictors
overall
infant
maternal
health,
respectively.
Methods
In
Understanding
Pregnancy
Signals
Infant
Development
(UPSIDE/UPSIDE-MOMs)
study
(
n
=
243;
Rochester,
NY),
we
examined
second
trimester
serum
(PFOS:
perfluorooctanesulfonic
acid,
PFOA:
perfluorooctanoic
PFNA:
perfluorononanoic
PFHxS:
perfluorohexanesulfonic
PFDA:
perfluorodecanoic
acid)
relation
GWG
(kg,
weekly
rate
gain)
postpartum,
retention
(PPWR
(kg)
total
fat
percentage
(measured
by
bioelectrical
impedance)).
We
fit
multivariable
linear
regression
models
examining
these
outcomes
log-transformed
whole
cohort
as
well
stratified
pre-pregnancy
BMI
(<
25
vs.
>
kg/m
2
),
adjusting
for
demographics
lifestyle
factors.
used
weighted
quantile
sum
find
combined
influence
5
on
GWG,
PPWR,
percentage.
Results
PFOA
PFHxS
were
inversely
associated
with
(PFOA:
ß
-1.54
kg,
95%CI:
-2.79,
-0.30;
-0.05
kg/week,
-0.09,
-0.01;
-1.59
-3.39,
0.21;
-0.11,
0.01)
PPWR
at
6
12
months
(PFOA
months:
-2.39
-4.17,
-0.61;
-4.02
-6.58,
-1.46;
-2.94
-5.52,
-0.35;
-5.13
-8.34,
-1.93).
was
additionally
lower
(ß
-1.75,
-3.17,
-0.32;
-1.64,
-3.43,
0.16,
respectively)
stronger
associations
observed
participants
higher
BMI.
The
mixture
-2.030,
-3.486,
-0.573)
amongst
all
participants.
Conclusion
PFAS,
particular
PFHxS,
pregnancy
patterns
adiposity
potential
implications
fetal
development
long-term
cardiometabolic
health.
Environmental Health,
Год журнала:
2023,
Номер
22(1)
Опубликована: Май 10, 2023
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
used
for
their
properties
such
as
stain
water
resistance.
The
have
been
associated
with
adverse
health
outcomes
in
both
pregnant
mothers
infants,
including
pre-eclampsia
low
birthweight.
A
growing
body
of
research
suggests
that
PFAS
transferred
from
mother
to
fetus
through
the
placenta,
leading
utero
exposure.
systematic
review
was
performed
using
PubMed
database
search
studies
evaluating
determinants
concentrations
blood
matrices
neonates
shortly
after
birth.
Studies
were
included
this
if
an
observational
study
design
utilized,
exposure
at
least
one
analyte
measured,
measured
maternal
or
neonatal
matrices,
determinant
assessed,
results
beta
estimates
provided.
We
identified
35
inclusion
evaluated
relationships
among
factors
collected
these
studies.
Parity,
breastfeeding
history,
race
country
origin,
household
income
had
strongest
most
consistent
evidence
support
roles
certain
mothers.
Reported
findings
on
smoking
status,
alcohol
consumption,
pre-pregnancy
mass
index
(BMI)
suggest
not
important
neonates.
Further
into
informative
consumer
product
use,
detailed
dietary
information,
consumed
sources
potential
is
needed.
Research
critical
estimate
past
exposure,
build
improved
models,
further
our
understanding
dose-response
relationships,
which
can
influence
epidemiological
risk
assessment
evaluations.
Given
exposed
PFAS,
it
identify
understand
better
implement
public
interventions
populations.
Environmental Health Perspectives,
Год журнала:
2023,
Номер
131(3)
Опубликована: Март 1, 2023
Background:
Human
breast
milk
is
a
primary
route
of
exposure
to
perfluoroalkyl
substances
(PFAS)
in
infants.
To
understand
the
associated
risks,
occurrence
PFAS
human
and
toxicokinetics
infants
need
be
addressed.
Objectives:
We
determined
levels
emerging
legacy
urine
samples
from
Chinese
breastfed
infants,
estimated
renal
clearance,
predicted
infant
serum
levels.
Methods:
In
total,
were
collected
1,151
lactating
mothers
21
cities
China.
addition,
80
paired
cord
blood
obtained
two
cities.
Nine
13
analyzed
using
ultra
high-performance
liquid
chromatography
tandem
mass
spectrometry.
Renal
clearance
rates
(CLrenals)
samples.
concentrations
(<1
year
age)
first-order
pharmacokinetic
model.
Results:
All
nine
detected
milk,
with
detection
6:2
Cl-PFESA,
PFMOAA,
PFO5DoDA
all
exceeding
70%.
The
level
Cl-PFESA
(median
concentration=13.6
ng/L)
ranked
third
after
PFOA
(336
PFOS
(49.7
ng/L).
daily
intake
(EDI)
values
exceeded
reference
dose
(RfD)
20
ng/kg
BW
per
day
recommended
by
U.S.
Environmental
Protection
Agency
78%
17%
samples,
respectively.
had
lowest
CLrenal
(0.009mL/kg
day),
corresponding
longest
half-life
49
y.
average
half-lives
PFO2HxA,
PFO3OA
0.221,
0.075,
0.304
y,
CLrenals
PFOA,
PFNA,
PFDA
slower
than
adults.
Conclusions:
Our
results
demonstrate
widespread
relatively
high
EDIs
suggest
potential
health
risks
postnatal
newborns.
https://doi.org/10.1289/EHP11403
Sustainability,
Год журнала:
2023,
Номер
15(23), С. 16173 - 16173
Опубликована: Ноя. 21, 2023
Per
and
polyfluoroalkyl
substances
(PFAS)
have
been
extensively
employed
in
a
broad
range
of
manufacturing
consumer
goods
due
to
their
highly
persistent
nature.
PFAS
exposure
is
recognized
pose
serious
health
hazards;
therefore,
addressing
pollution
water
has
become
top
priority
for
public
environmental
protection
organizations.
This
review
article
focuses
on
the
efficiency
different
removal
techniques
(activated
carbon,
biochar,
ion
exchange
resin,
membrane
filtration,
reverse
osmosis,
metal-organic
frameworks,
foam
fractionation,
ozone
destruction
techniques)
eliminating
types
short-
long-chain
from
water.
Hydrophobicity
electrostatic
interactions
are
revealed
be
primary
mechanisms
elimination
PFAS.
The
all
eradicate
short-chain
comparatively
lower
compared
most
efficient
but
some
drawbacks,
including
formation
precursors
high
operational
costs.
According
findings
study,
it
anticipated
that
combined
methods
will
required
effectively
remediate
PFAS-contaminated
Toxicological Sciences,
Год журнала:
2023,
Номер
194(2), С. 138 - 152
Опубликована: Май 23, 2023
Abstract
The
existence
of
thousands
per-
and
polyfluoroalkyl
substances
(PFAS)
evidence
that
some
cause
adverse
health
effects
has
created
immense
need
to
better
understand
PFAS
toxicity
move
beyond
one-chemical-at-a-time
approaches
hazard
assessment
for
this
chemical
class.
zebrafish
model
enables
rapid
large
libraries
PFAS,
powerful
comparison
compounds
in
a
single
vivo
system,
evaluation
across
life
stages
generations,
led
significant
advances
research
recent
years.
focus
review
is
assess
contemporary
findings
regarding
toxicokinetics,
apical
outcomes,
potential
modes
action
using
the
model.
Much
peer-reviewed
literature
focused
on
small
subset
structural
subclasses,
such
as
perfluoroalkyl
sulfonic
acids
carboxylic
acids.
However,
data
more
diverse
structures
are
enabling
prioritization
concern.
Structure-activity
comparisons
utilization
modeling
‘omics
technologies
have
greatly
contributed
our
understanding
growing
number
will
surely
inform
predictive
capabilities
many
future.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Perfluorooctanoic
acid
(PFOA)
is
a
persistent
pollutant
that
has
gained
worldwide
attention,
owing
to
its
widespread
presence
in
the
environment.
Previous
studies
have
reported
PFOA
upregulates
lipid
metabolism
and
associated
with
liver
injury
humans.
However,
when
fatty
degradation
pathway
activated,
accumulation
still
occurs,
suggesting
of
unknown
pathways
mechanisms
remain
be
elucidated.
In
this
study,
adult
C57BL/6N
mice
were
exposed
at
0.1,
1,
10
mg/kg/day.
Using
integrated
metabolomics
transcriptomics,
it
was
uncovered
arginine
differentially
downregulated
all
three
groups.
vitro
confirmed
downregulation
MIHA
cell
lines
treated
PFOA.
Supplementation
could
effectively
rescue
downregulate
chemokine
levels
caused
by
This
finding
highlights
contribution
maintaining
health
following
exposure
suggests
potential
metabolic
immune
modulation.
Environmental Health,
Год журнала:
2025,
Номер
24(1)
Опубликована: Март 15, 2025
Extensive
use
of
per-
and
polyfluoroalkyl
substances
(PFAS)
has
resulted
in
their
ubiquitous
presence
human
blood.
PFAS
exposures
have
been
associated
with
multiple
adverse
health
effects.
Biomonitoring
studies
focused
on
long-chain
PFASs,
but
these
are
being
replaced
by
short-chain
PFASs
or
alternate
chemistries
(or
replacement
such
as
GenX),
resulting
changes
time.
Here,
we
take
advantage
serum
samples
collected
part
a
clinical
trial
testing
the
efficacy
dietary
fiber
intervention
to
reduce
cholesterol
investigate
exposure
Canadian
participants.
Serum
were
from
72
participants
(adult
males
elevated
cholesterol)
2019–2020
at
baseline
after
4
weeks
analyzed
for
17
PFASs.
The
highest
geometric
mean
concentrations
measured
corresponded
PFOSA
(7.1
ng/ml),
PFOS
(4.2,
PFOA
(1.8
ng/ml)
PFHxS
(1.3
ng/ml).
Four
(PFOA,
PFOS,
PFHxS)
two
(PFBA,
PFHxA)
detected
100%
GenX
was
71%
Analyses
associations
between
serum-PFAS
biomarkers
outcomes
showed
PFBA,
PFHxA,
PFDA
higher
gamma-glutamyl
transferase
not
measures
serum-total
low-density
lipoprotein
cholesterol.
Comparison
4-week
follow-up
that
total
decreased
both
control
groups.
However,
suite
concern
identified
United
States
National
Academies
Sciences,
Engineering,
Medicine,
significantly
only
group.
This
observation
suggests
sustained
may
body
burden,
future
need
sources
extend
supplement
intake
beyond
weeks.
Overall,
results
show
chemistry
common
this
population.