Per- and polyfluoroalkyl substances, gestational weight gain, postpartum weight retention and body composition in the UPSIDE cohort DOI Creative Commons
Carolyn Waugh Kinkade, Zorimar Rivera‐Núñez, Sally W. Thurston

и другие.

Environmental Health, Год журнала: 2023, Номер 22(1)

Опубликована: Сен. 2, 2023

Abstract Background Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals found in drinking water consumer products, resulting ubiquitous human exposure. PFAS have been linked to endocrine disruption altered weight gain across the lifespan. A limited inconsistent body of research suggests may impact gestational (GWG) postpartum mass index (BMI), which important predictors overall infant maternal health, respectively. Methods In Understanding Pregnancy Signals Infant Development (UPSIDE/UPSIDE-MOMs) study ( n = 243; Rochester, NY), we examined second trimester serum (PFOS: perfluorooctanesulfonic acid, PFOA: perfluorooctanoic PFNA: perfluorononanoic PFHxS: perfluorohexanesulfonic PFDA: perfluorodecanoic acid) relation GWG (kg, weekly rate gain) postpartum, retention (PPWR (kg) total fat percentage (measured by bioelectrical impedance)). We fit multivariable linear regression models examining these outcomes log-transformed whole cohort as well stratified pre-pregnancy BMI (< 25 vs. > kg/m 2 ), adjusting for demographics lifestyle factors. used weighted quantile sum find combined influence 5 on GWG, PPWR, percentage. Results PFOA PFHxS were inversely associated with (PFOA: ß -1.54 kg, 95%CI: -2.79, -0.30; -0.05 kg/week, -0.09, -0.01; -1.59 -3.39, 0.21; -0.11, 0.01) PPWR at 6 12 months (PFOA months: -2.39 -4.17, -0.61; -4.02 -6.58, -1.46; -2.94 -5.52, -0.35; -5.13 -8.34, -1.93). was additionally lower (ß -1.75, -3.17, -0.32; -1.64, -3.43, 0.16, respectively) stronger associations observed participants higher BMI. The mixture -2.030, -3.486, -0.573) amongst all participants. Conclusion PFAS, particular PFHxS, pregnancy patterns adiposity potential implications fetal development long-term cardiometabolic health.

Язык: Английский

The regulation of endocrine-disrupting chemicals to minimize their impact on health DOI
Carol Duh‐Leong, Maricel V. Maffini, Christopher D. Kassotis

и другие.

Nature Reviews Endocrinology, Год журнала: 2023, Номер 19(10), С. 600 - 614

Опубликована: Авг. 8, 2023

Язык: Английский

Процитировано

53
Determinants of maternal and neonatal PFAS concentrations: a review DOI Creative Commons
Jordan McAdam, Erin M. Bell

Environmental Health, Год журнала: 2023, Номер 22(1)

Опубликована: Май 10, 2023

Per- and polyfluoroalkyl substances (PFAS) are used for their properties such as stain water resistance. The have been associated with adverse health outcomes in both pregnant mothers infants, including pre-eclampsia low birthweight. A growing body of research suggests that PFAS transferred from mother to fetus through the placenta, leading utero exposure. systematic review was performed using PubMed database search studies evaluating determinants concentrations blood matrices neonates shortly after birth. Studies were included this if an observational study design utilized, exposure at least one analyte measured, measured maternal or neonatal matrices, determinant assessed, results beta estimates provided. We identified 35 inclusion evaluated relationships among factors collected these studies. Parity, breastfeeding history, race country origin, household income had strongest most consistent evidence support roles certain mothers. Reported findings on smoking status, alcohol consumption, pre-pregnancy mass index (BMI) suggest not important neonates. Further into informative consumer product use, detailed dietary information, consumed sources potential is needed. Research critical estimate past exposure, build improved models, further our understanding dose-response relationships, which can influence epidemiological risk assessment evaluations. Given exposed PFAS, it identify understand better implement public interventions populations.

Язык: Английский

Процитировано

45
Per-and polyfluoroalkyl substances (PFAS) as a health hazard: Current state of knowledge and strategies in environmental settings across Asia and future perspectives DOI

Karuna Singh,

Naresh Kumar, Asheesh Kumar Yadav

и другие.

Chemical Engineering Journal, Год журнала: 2023, Номер 475, С. 145064 - 145064

Опубликована: Июль 29, 2023

Язык: Английский

Процитировано

44
Emerging and Legacy Perfluoroalkyl Substances in Breastfed Chinese Infants: Renal Clearance, Body Burden, and Implications DOI Creative Commons
Jingzhi Yao, Zhaomin Dong,

Lulin Jiang

и другие.

Environmental Health Perspectives, Год журнала: 2023, Номер 131(3)

Опубликована: Март 1, 2023

Background: Human breast milk is a primary route of exposure to perfluoroalkyl substances (PFAS) in infants. To understand the associated risks, occurrence PFAS human and toxicokinetics infants need be addressed. Objectives: We determined levels emerging legacy urine samples from Chinese breastfed infants, estimated renal clearance, predicted infant serum levels. Methods: In total, were collected 1,151 lactating mothers 21 cities China. addition, 80 paired cord blood obtained two cities. Nine 13 analyzed using ultra high-performance liquid chromatography tandem mass spectrometry. Renal clearance rates (CLrenals) samples. concentrations (<1 year age) first-order pharmacokinetic model. Results: All nine detected milk, with detection 6:2 Cl-PFESA, PFMOAA, PFO5DoDA all exceeding 70%. The level Cl-PFESA (median concentration=13.6 ng/L) ranked third after PFOA (336 PFOS (49.7 ng/L). daily intake (EDI) values exceeded reference dose (RfD) 20 ng/kg BW per day recommended by U.S. Environmental Protection Agency 78% 17% samples, respectively. had lowest CLrenal (0.009mL/kg day), corresponding longest half-life 49 y. average half-lives PFO2HxA, PFO3OA 0.221, 0.075, 0.304 y, CLrenals PFOA, PFNA, PFDA slower than adults. Conclusions: Our results demonstrate widespread relatively high EDIs suggest potential health risks postnatal newborns. https://doi.org/10.1289/EHP11403

Язык: Английский

Процитировано

38
A Critical Review on PFAS Removal from Water: Removal Mechanism and Future Challenges DOI Open Access
Rabia Amen, Alhassan Ibrahim, Waqar Shafqat

и другие.

Sustainability, Год журнала: 2023, Номер 15(23), С. 16173 - 16173

Опубликована: Ноя. 21, 2023

Per and polyfluoroalkyl substances (PFAS) have been extensively employed in a broad range of manufacturing consumer goods due to their highly persistent nature. PFAS exposure is recognized pose serious health hazards; therefore, addressing pollution water has become top priority for public environmental protection organizations. This review article focuses on the efficiency different removal techniques (activated carbon, biochar, ion exchange resin, membrane filtration, reverse osmosis, metal-organic frameworks, foam fractionation, ozone destruction techniques) eliminating types short- long-chain from water. Hydrophobicity electrostatic interactions are revealed be primary mechanisms elimination PFAS. The all eradicate short-chain comparatively lower compared most efficient but some drawbacks, including formation precursors high operational costs. According findings study, it anticipated that combined methods will required effectively remediate PFAS-contaminated

Язык: Английский

Процитировано

33
Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity DOI Creative Commons
Yvonne Rericha, Michael T. Simonich, Lisa Truong

и другие.

Toxicological Sciences, Год журнала: 2023, Номер 194(2), С. 138 - 152

Опубликована: Май 23, 2023

Abstract The existence of thousands per- and polyfluoroalkyl substances (PFAS) evidence that some cause adverse health effects has created immense need to better understand PFAS toxicity move beyond one-chemical-at-a-time approaches hazard assessment for this chemical class. zebrafish model enables rapid large libraries PFAS, powerful comparison compounds in a single vivo system, evaluation across life stages generations, led significant advances research recent years. focus review is assess contemporary findings regarding toxicokinetics, apical outcomes, potential modes action using the model. Much peer-reviewed literature focused on small subset structural subclasses, such as perfluoroalkyl sulfonic acids carboxylic acids. However, data more diverse structures are enabling prioritization concern. Structure-activity comparisons utilization modeling ‘omics technologies have greatly contributed our understanding growing number will surely inform predictive capabilities many future.

Язык: Английский

Процитировано

25
Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury DOI
Jie Gao, Tiantian Li, Wei Guo

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported PFOA upregulates lipid metabolism and associated with liver injury humans. However, when fatty degradation pathway activated, accumulation still occurs, suggesting of unknown pathways mechanisms remain be elucidated. In this study, adult C57BL/6N mice were exposed at 0.1, 1, 10 mg/kg/day. Using integrated metabolomics transcriptomics, it was uncovered arginine differentially downregulated all three groups. vitro confirmed downregulation MIHA cell lines treated PFOA. Supplementation could effectively rescue downregulate chemokine levels caused by This finding highlights contribution maintaining health following exposure suggests potential metabolic immune modulation.

Язык: Английский

Процитировано

2
Three-year field study on the temporal response of soil microbial communities and functions to PFOA exposure DOI

H.S. Huang,

Xueyan Lyu,

Xiao Feng

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 476, С. 135008 - 135008

Опубликована: Июнь 25, 2024

Язык: Английский

Процитировано

8
Sex-Specific Effects of In Utero Exposure to Per- and Polyfluoroalkyl Substances on Placental Development DOI

Cynthia Michelle Perez,

Neha Sehgal, Stephanie M. Eick

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 120868 - 120868

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS DOI Creative Commons
Jennifer J. Schlezinger, Anila Bello, Kelsey M. Mangano

и другие.

Environmental Health, Год журнала: 2025, Номер 24(1)

Опубликована: Март 15, 2025

Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence human blood. PFAS exposures have been associated with multiple adverse health effects. Biomonitoring studies focused on long-chain PFASs, but these are being replaced by short-chain PFASs or alternate chemistries (or replacement such as GenX), resulting changes time. Here, we take advantage serum samples collected part a clinical trial testing the efficacy dietary fiber intervention to reduce cholesterol investigate exposure Canadian participants. Serum were from 72 participants (adult males elevated cholesterol) 2019–2020 at baseline after 4 weeks analyzed for 17 PFASs. The highest geometric mean concentrations measured corresponded PFOSA (7.1 ng/ml), PFOS (4.2, PFOA (1.8 ng/ml) PFHxS (1.3 ng/ml). Four (PFOA, PFOS, PFHxS) two (PFBA, PFHxA) detected 100% GenX was 71% Analyses associations between serum-PFAS biomarkers outcomes showed PFBA, PFHxA, PFDA higher gamma-glutamyl transferase not measures serum-total low-density lipoprotein cholesterol. Comparison 4-week follow-up that total decreased both control groups. However, suite concern identified United States National Academies Sciences, Engineering, Medicine, significantly only group. This observation suggests sustained may body burden, future need sources extend supplement intake beyond weeks. Overall, results show chemistry common this population.

Язык: Английский

Процитировано

1