Adipogenic and osteogenic effects of OBS and synergistic action with PFOS via PPARγ–RXRα heterodimers DOI Creative Commons
Hui Qin,

Yueming Lang,

Yiteng Wang

et al.

Environment International, Journal Year: 2023, Volume and Issue: 183, P. 108354 - 108354

Published: Nov. 25, 2023

Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is a novel alternative to perfluorooctane sulfonate (PFOS), with environmental health risks largely unknown. The present study aims unravel the adipogenesis effects and underlying molecular initiating events of OBS, which are crucial for understanding predicting its adverse outcome. In undifferentiated human mesenchymal stem cells (hMSCs), exposure 1-100 nM OBS 7 days stimulated reactive oxygen species production. subsequent multipotent differentiation, hMSCs favored repressed osteogenesis. point departure (PoD) cellular responses was 38.85 nM, higher than PFOS (0.39 nM). Notably, OBS/PFOS co-exposure inhibited osteogenesis synergistically promoted adipogenesis. Consistently, expression adipogenic marker genes up-regulated, while that osteogenic down-regulated. decreased adiponectin elevated tumour necrosis factor α (TNFα) secretion were observed in differentiated exposed mixture PFOS. co-treatment peroxisome proliferator-activated receptor γ (PPARγ) antagonist alleviated combination OBS. Moreover, induced PPARγ activation reporter gene assays, increased formation - retinoid X (RXRα) heterodimers measured by co-immunoprecipitation assays. Molecular docking showed interaction energy (-20.7 kcal/mol) intact PPARγ-RXRα complex lower (-25.9 kcal/mol). Overall, single exhibited potency inducing but comparable repressing osteogenesis, whereas increases heterodimers, resulting synergistic PPARγ, ultimately enhancing at expense differentiation. results indicate potential obesity bone density caused PFOS, as well other perfluorinated alkylated substances mixtures.

Language: Английский

The regulation of endocrine-disrupting chemicals to minimize their impact on health DOI
Carol Duh‐Leong, Maricel V. Maffini, Christopher D. Kassotis

et al.

Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(10), P. 600 - 614

Published: Aug. 8, 2023

Language: Английский

Citations

51
Determinants of maternal and neonatal PFAS concentrations: a review DOI Creative Commons
Jordan McAdam, Erin M. Bell

Environmental Health, Journal Year: 2023, Volume and Issue: 22(1)

Published: May 10, 2023

Per- and polyfluoroalkyl substances (PFAS) are used for their properties such as stain water resistance. The have been associated with adverse health outcomes in both pregnant mothers infants, including pre-eclampsia low birthweight. A growing body of research suggests that PFAS transferred from mother to fetus through the placenta, leading utero exposure. systematic review was performed using PubMed database search studies evaluating determinants concentrations blood matrices neonates shortly after birth. Studies were included this if an observational study design utilized, exposure at least one analyte measured, measured maternal or neonatal matrices, determinant assessed, results beta estimates provided. We identified 35 inclusion evaluated relationships among factors collected these studies. Parity, breastfeeding history, race country origin, household income had strongest most consistent evidence support roles certain mothers. Reported findings on smoking status, alcohol consumption, pre-pregnancy mass index (BMI) suggest not important neonates. Further into informative consumer product use, detailed dietary information, consumed sources potential is needed. Research critical estimate past exposure, build improved models, further our understanding dose-response relationships, which can influence epidemiological risk assessment evaluations. Given exposed PFAS, it identify understand better implement public interventions populations.

Language: Английский

Citations

41
Per-and polyfluoroalkyl substances (PFAS) as a health hazard: Current state of knowledge and strategies in environmental settings across Asia and future perspectives DOI

Karuna Singh,

Naresh Kumar, Asheesh Kumar Yadav

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 475, P. 145064 - 145064

Published: July 29, 2023

Language: Английский

Citations

40
Emerging and Legacy Perfluoroalkyl Substances in Breastfed Chinese Infants: Renal Clearance, Body Burden, and Implications DOI Creative Commons
Jingzhi Yao, Zhaomin Dong,

Lulin Jiang

et al.

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(3)

Published: March 1, 2023

Background: Human breast milk is a primary route of exposure to perfluoroalkyl substances (PFAS) in infants. To understand the associated risks, occurrence PFAS human and toxicokinetics infants need be addressed. Objectives: We determined levels emerging legacy urine samples from Chinese breastfed infants, estimated renal clearance, predicted infant serum levels. Methods: In total, were collected 1,151 lactating mothers 21 cities China. addition, 80 paired cord blood obtained two cities. Nine 13 analyzed using ultra high-performance liquid chromatography tandem mass spectrometry. Renal clearance rates (CLrenals) samples. concentrations (<1 year age) first-order pharmacokinetic model. Results: All nine detected milk, with detection 6:2 Cl-PFESA, PFMOAA, PFO5DoDA all exceeding 70%. The level Cl-PFESA (median concentration=13.6 ng/L) ranked third after PFOA (336 PFOS (49.7 ng/L). daily intake (EDI) values exceeded reference dose (RfD) 20 ng/kg BW per day recommended by U.S. Environmental Protection Agency 78% 17% samples, respectively. had lowest CLrenal (0.009mL/kg day), corresponding longest half-life 49 y. average half-lives PFO2HxA, PFO3OA 0.221, 0.075, 0.304 y, CLrenals PFOA, PFNA, PFDA slower than adults. Conclusions: Our results demonstrate widespread relatively high EDIs suggest potential health risks postnatal newborns. https://doi.org/10.1289/EHP11403

Language: Английский

Citations

36
A Critical Review on PFAS Removal from Water: Removal Mechanism and Future Challenges DOI Open Access
Rabia Amen, Alhassan Ibrahim, Waqar Shafqat

et al.

Sustainability, Journal Year: 2023, Volume and Issue: 15(23), P. 16173 - 16173

Published: Nov. 21, 2023

Per and polyfluoroalkyl substances (PFAS) have been extensively employed in a broad range of manufacturing consumer goods due to their highly persistent nature. PFAS exposure is recognized pose serious health hazards; therefore, addressing pollution water has become top priority for public environmental protection organizations. This review article focuses on the efficiency different removal techniques (activated carbon, biochar, ion exchange resin, membrane filtration, reverse osmosis, metal-organic frameworks, foam fractionation, ozone destruction techniques) eliminating types short- long-chain from water. Hydrophobicity electrostatic interactions are revealed be primary mechanisms elimination PFAS. The all eradicate short-chain comparatively lower compared most efficient but some drawbacks, including formation precursors high operational costs. According findings study, it anticipated that combined methods will required effectively remediate PFAS-contaminated

Language: Английский

Citations

30
Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury DOI
Jie Gao, Tiantian Li, Wei Guo

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported PFOA upregulates lipid metabolism and associated with liver injury humans. However, when fatty degradation pathway activated, accumulation still occurs, suggesting of unknown pathways mechanisms remain be elucidated. In this study, adult C57BL/6N mice were exposed at 0.1, 1, 10 mg/kg/day. Using integrated metabolomics transcriptomics, it was uncovered arginine differentially downregulated all three groups. vitro confirmed downregulation MIHA cell lines treated PFOA. Supplementation could effectively rescue downregulate chemokine levels caused by This finding highlights contribution maintaining health following exposure suggests potential metabolic immune modulation.

Language: Английский

Citations

1
Per- and poly-fluoroalkyl substances (PFAS) in circulation in a Canadian population: their association with serum-liver enzyme biomarkers and piloting a novel method to reduce serum-PFAS DOI Creative Commons
Jennifer J. Schlezinger, Anila Bello, Kelsey M. Mangano

et al.

Environmental Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 15, 2025

Extensive use of per- and polyfluoroalkyl substances (PFAS) has resulted in their ubiquitous presence human blood. PFAS exposures have been associated with multiple adverse health effects. Biomonitoring studies focused on long-chain PFASs, but these are being replaced by short-chain PFASs or alternate chemistries (or replacement such as GenX), resulting changes time. Here, we take advantage serum samples collected part a clinical trial testing the efficacy dietary fiber intervention to reduce cholesterol investigate exposure Canadian participants. Serum were from 72 participants (adult males elevated cholesterol) 2019–2020 at baseline after 4 weeks analyzed for 17 PFASs. The highest geometric mean concentrations measured corresponded PFOSA (7.1 ng/ml), PFOS (4.2, PFOA (1.8 ng/ml) PFHxS (1.3 ng/ml). Four (PFOA, PFOS, PFHxS) two (PFBA, PFHxA) detected 100% GenX was 71% Analyses associations between serum-PFAS biomarkers outcomes showed PFBA, PFHxA, PFDA higher gamma-glutamyl transferase not measures serum-total low-density lipoprotein cholesterol. Comparison 4-week follow-up that total decreased both control groups. However, suite concern identified United States National Academies Sciences, Engineering, Medicine, significantly only group. This observation suggests sustained may body burden, future need sources extend supplement intake beyond weeks. Overall, results show chemistry common this population.

Language: Английский

Citations

1
Review of the zebrafish as a model to investigate per- and polyfluoroalkyl substance toxicity DOI Creative Commons
Yvonne Rericha, Michael T. Simonich, Lisa Truong

et al.

Toxicological Sciences, Journal Year: 2023, Volume and Issue: 194(2), P. 138 - 152

Published: May 23, 2023

Abstract The existence of thousands per- and polyfluoroalkyl substances (PFAS) evidence that some cause adverse health effects has created immense need to better understand PFAS toxicity move beyond one-chemical-at-a-time approaches hazard assessment for this chemical class. zebrafish model enables rapid large libraries PFAS, powerful comparison compounds in a single vivo system, evaluation across life stages generations, led significant advances research recent years. focus review is assess contemporary findings regarding toxicokinetics, apical outcomes, potential modes action using the model. Much peer-reviewed literature focused on small subset structural subclasses, such as perfluoroalkyl sulfonic acids carboxylic acids. However, data more diverse structures are enabling prioritization concern. Structure-activity comparisons utilization modeling ‘omics technologies have greatly contributed our understanding growing number will surely inform predictive capabilities many future.

Language: Английский

Citations

21
Three-year field study on the temporal response of soil microbial communities and functions to PFOA exposure DOI

H.S. Huang,

Xueyan Lyu,

Xiao Feng

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135008 - 135008

Published: June 25, 2024

Language: Английский

Citations

7
Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder DOI Creative Commons
Claudia Gundacker, Karine Audouze, Raimund Widhalm

et al.

Toxics, Journal Year: 2022, Volume and Issue: 10(11), P. 684 - 684

Published: Nov. 12, 2022

Prenatal exposure to per- and polyfluorinated substances (PFAS) may impair fetal growth. Our knowledge of the underlying mechanisms is incomplete. We used Adverse Outcome Pathway (AOP)-helpFinder tool search PubMed for studies published until March 2021 that examined PFAS in relation birth weight, oxidative stress, hormones/hormone receptors, or growth signaling pathways. Of these 1880 articles, 106 experimental remained after abstract screening. One clear finding are associated with stress vivo animal vitro studies. It appears PFAS-induced reactive-oxygen species (ROS) generation triggers increased peroxisome proliferator-activated receptor (PPAR)γ expression activation pathways, leading hyperdifferentiation pre-adipocytes. Fewer proliferating pre-adipocytes result lower adipose tissue weight this way reduce weight. also through endocrine effects. Estrogenic effects have been noted Overall, data suggest thyroid-damaging affecting thyroid hormones, hormone gene expression, histology decreased body organ The on complex relationships between system function, adipogenesis, should be further explored.

Language: Английский

Citations

25