Journal of Applied Toxicology,
Год журнала:
2023,
Номер
44(4), С. 488 - 500
Опубликована: Сен. 12, 2023
Abstract
Based
on
the
87
original
publications
only
from
quartiles
1
and
2
of
Journal
Citation
Report
(JCR)
collected
by
major
academic
databases
(Science
Direct,
Web
Science,
PubMed,
Wiley)
in
2022,
frontier
toxicology
studies
zebrafish
model
is
summarized.
Herewith,
a
total
six
aspects
covered
such
as
developmental,
neurological,
cardiovascular,
hepatic,
reproductive,
immunizing
toxicities.
The
tested
samples
involve
chemicals,
drugs,
new
environmental
pollutants,
nanomaterials,
its
derivatives,
along
with
those
related
mechanisms.
This
report
may
provide
focus
benefit
to
researchers
engaging
for
environment,
medicine,
food,
other
fields.
Environment International,
Год журнала:
2024,
Номер
189, С. 108795 - 108795
Опубликована: Июнь 1, 2024
Bisphenol
G
(BPG),
bisphenol
M
(BPM)
and
TMC
(BPTMC),
are
newly
recognized
analogues
of
A
(BPA),
which
have
been
detected
in
multiple
environmental
media.
However,
the
understanding
their
negative
impacts
on
health
is
limited.
In
this
study,
zebrafish
embryos
were
exposed
to
BPA
three
(0.1,
10,
1000
μg/L)
identify
developmental
toxic
effects.
According
our
results,
all
induced
significant
disorders
including
inhibited
yolk
sac
absorption,
altered
heart
rate,
teratogenic
Oil
Red
O
staining
indicated
lipid
accumulation
region
after
exposure,
was
consistent
with
delayed
uptake.
Untargeted
lipidomic
analysis
abundance
triacylglycerol,
ceramide
fatty
acids
significantly
by
analogues.
The
combined
lipidomics
transcriptomics
results
BPG
BPM
affected
metabolism
disrupting
peroxisome
proliferator-activated
receptor
pathway
interfering
homeostasis
transport.
This
partly
explained
morphological
changes
exposure.
conclusion,
study
reveals
that
BPG,
BPTMC
possess
acute
toxicity
toward
zebrafish,
abnormalities
associated
disturbances
metabolism.
Frontiers in Toxicology,
Год журнала:
2024,
Номер
6
Опубликована: Июль 22, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
a
widespread
persistent
class
of
contaminants
posing
significant
environmental
human
health
concerns.
Comprehensive
understanding
the
modes
action
underlying
toxicity
among
structurally
diverse
PFAS
is
mostly
lacking.
To
address
this
need,
we
recently
reported
on
our
application
developing
zebrafish
to
evaluate
large
library
for
developmental
toxicity.
In
present
study,
prioritized
15
bioactive
that
induced
morphological
effects
performed
RNA-sequencing
characterize
early
transcriptional
responses
at
single
timepoint
(48
h
post
fertilization)
after
exposures
(8
fertilization).
Internal
concentrations
5
were
measured
from
pooled
whole
fish
samples
across
multiple
timepoints
between
24–120
fertilization,
additional
temporal
transcriptomics
several
(48–96
conducted
Nafion
byproduct
2.
A
broad
range
differentially
expressed
gene
counts
identified
exposures.
Most
elicited
robust
transcriptomic
changes
affected
biological
processes
brain
nervous
system
development.
While
disrupted
unique
processes,
also
found
similarities
in
some
functional
head
groups
associated
with
disruption
expression
similar
sets.
Body
burdens
select
sulfonic
acid
PFAS,
including
2,
increased
24–96
fertilization
sampling
greater
than
those
sulfonamide
chain
lengths.
parallel,
2-induced
48
96
fertilization.
characteristics
based
toxicity,
effects,
will
contribute
further
prioritization
structures
testing
informed
hazard
assessment.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 19, 2025
Anti-programmed
death
1
(αPD1)
immune
checkpoint
blockade
is
used
in
combination
for
cancer
treatment
but
associated
with
cardiovascular
toxicity.
Leflunomide
(Lef)
can
suppress
the
growth
of
several
tumor
and
mitigate
cardiac
remodeling
mice.
However,
role
Lef
αPD1-induced
cardiotoxicity
remains
unclear.
Here,
we
report
that
inhibits
αPD1-related
without
compromising
efficacy
αPD1-mediated
immunotherapy.
changes
community
structure
gut
microbiota
αPD1-treated
melanoma-bearing
Moreover,
mice
receiving
transplants
from
Lef+αPD1-treated
have
better
function
compared
to
Mechanistically,
analyze
metabolomics
identify
indole-3-propionic
acid
(IPA),
which
protects
dysfunction
IPA
directly
bind
aryl
hydrocarbon
receptor
promote
phosphoinositide
3-kinase
expression,
thus
curtailing
cardiomyocyte
response
injury.
Our
findings
reveal
mitigates
toxicity
through
modulation
microbiota-IPA-heart
axis.
The
authors
show
leflunomide
microbiota-indole-3-propionic
acid-heart
