Weakened serum albumin binding-to-activated EGFR internalization in cellular accumulation for the synergistic toxicity of tetrabromobisphenol A and perfluorooctanoic acid

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study

International Journal of Hygiene and Environmental Health, Год журнала: 2024, Номер 258, С. 114359 - 114359

Опубликована: Март 22, 2024

Язык: Английский

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Quantifying levels of per- and polyfluoroalkyl Substances (PFAS) in water and serum after contamination from agricultural biosolid application

Environment International, Год журнала: 2024, Номер 190, С. 108850 - 108850

Опубликована: Июнь 24, 2024

The National Academies of Sciences, Engineering, and Medicine recommends per- polyfluoroalkyl substance (PFAS) blood testing for patients with risk elevated exposure, the Agency Toxic Substances Disease Registry (ATSDR) suggests PFAS based on exposure. Barriers to include cost, access labs, evolving laboratory methods. We quantify water serum levels among a highly-exposed cohort in an area groundwater contaminated by historical agricultural biosolid application. compare gold standard test commercial results from one-compartment toxicokinetic model. Participants were adults (n = 30) whose household 19) had sum six > 500 ng/L. Serum measured using liquid chromatography-tandem mass spectrometry. Demographic consumption data collected via telephone. accessed medical record. Statistical analysis included descriptive statistics bivariate plots levels. Perfluorohexanoic acid, perfluoroheptanoic acid (PFHpA), perfluorooctanoic (PFOA), perfluorononanoic (PFNA), perfluorobutanesulfonic perfluorohexanesulfonic (PFHxS), perfluorooctanesulfonic (PFOS) detected 19 wells, PFHpA, PFOA, PFNA, perfluorodecanoic perfluoroundecanoic PFHxS, PFOS at least participants' serum. In well water, PFOA geometric means (GMs) 1749 ng/L (geometric deviation [GSD] 2.4) 887 (GSD 19.7), respectively. serum, GMs 116.2 µg/L 13.5) 58.3 13.8), Our are comparable wider mix than other high-exposure cohorts. There was good agreement between tests mixed modeled predictions, suggesting water-based models may be inadequate assessing exposure this population.

Язык: Английский

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Screening Novel Per- and Polyfluoroalkyl Substances in Human Blood Based on Nontarget Analysis and Underestimated Potential Health Risks

Environmental Science & Technology, Год журнала: 2023, Номер 58(1), С. 150 - 159

Опубликована: Дек. 28, 2023

Nontarget analysis has gained prominence in screening novel perfluoroalkyl and polyfluoroalkyl substances (PFASs) the environment, yet remaining limited human biological matrices. In this study, 155 whole blood samples were collected from general population Shijiazhuang City, China. By nontarget analysis, 31 legacy PFASs assigned with confidence level of 3 or above. For first time, 11 identified blood, including C1 C3 sulfonic acids (PFSAs), C4 ether PFSA, C8 carboxylic acid (ether PFCA), C4–5 unsaturated alcohols, C9–10 acid-perfluoroalkyl sulfonamides (CA-PFSMs), sulfonamide. It is surprising that targeted highest suburban which was impacted by industrial emission, while such as PFSA C9–11 CA-PFSMs, rural who often drank contaminated groundwater. Combining toxicity prediction results bioaccumulation potential, lethality to rats, binding affinity target proteins, C7 PFSAs, CA-PFSMs exhibit great health risks. These findings emphasize necessity broadening assessing PFAS exposure risks, particularly populations.

Язык: Английский

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Plasma concentrations of per- and polyfluoroalkyl substances in pregnancy and breastfeeding duration in Project Viva

The Science of The Total Environment, Год журнала: 2023, Номер 891, С. 164724 - 164724

Опубликована: Июнь 7, 2023

Язык: Английский

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Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study: Matrix dependent partitioning differences compared to legacy POPs

Environment International, Год журнала: 2024, Номер 183, С. 108440 - 108440

Опубликована: Янв. 1, 2024

Polychlorinated alkanes (PCAs) constitute a large group of individual congeners originating from commercial chlorinated paraffin (CP) products with carbon chain lengths PCAs-C10-13, PCAs-C14-17, and PCAs-C18-32, occasionally containing PCAs-C6-9 impurities. The extensive use CPs has led to global environmental pollution PCAs. This study aimed quantify PCAs in paired serum breast milk lactating Swedish mothers, exploring their concentration relationship. Twenty-five samples mothers' blood were analysed concentrations determined for C6-32 compared 4,4'-DDE, the PCB congener 2,2',4,4',5,5'-hexachlorobipheny (CB-153), hexachlorobenzene (HCB). median PCAs-C6-9, PCAs-C18-32 ΣPCAs 14, 790, 520, 16 1350 ng/g lipid weight (lw) 0.84, 36, 63, 6.0 107 lw. Levels CB-153 HCB comparable two matrices, at 17, 12 4.9 results show significant differences PCAs-C10-13 PCAs-C14-17 22- 6.2-times lower lw-based than those measured serum. On wet serum/breast ratios 1.7, 3.2, 1.0, 0.4 1.6, respectively, while ratio each close 0.1. mothers had high concentration, although considerably lw, still surpassed HCB, suggesting an exposure risk infants PCA. variation accumulation between studied legacy POPs, is rarely discussed but warrants further studies on partitioning properties as well associated toxicological implications.

Язык: Английский

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Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk Over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 23, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are potentially related to many adverse health outcomes could be transferred from maternal blood human milk, which is an important exposure source for infants during a long-term period. In this study, the of 76 women after delivery their matched milk samples obtained at 0.5, 1, 3 months were analyzed by solid-phase extraction method with metal−organic framework/polymer hybrid nanofibers as sorbents ultrahigh-performance liquid chromatography-negative electrospray ionization mass spectrometric quantitative analysis 31 PFAS. The perfluorooctanoic acid, perfluorooctane sulfonate, N-methyl sulfonamido acetic acid (N-MeFOSAA) contributed more than approximately 50% total PFAS concentrations in while N-MeFOSAA (median: 0.274 ng/mL) was highest months. transfer efficiencies 0.5 generally lower, medians ranging 0.20% 16.9%. number species detected increased lactation time went on months, 10 displayed increasing trend prolongation (p < 0.05).

Язык: Английский

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Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice

Toxicological Sciences, Год журнала: 2024, Номер 201(1), С. 48 - 60

Опубликована: Июнь 3, 2024

Abstract Emerging epidemiological evidence indicates perfluorooctane sulfonic acid (PFOS) is increasingly associated with asthma and respiratory viral infections. Animal studies suggest PFOS disrupts lung development immuno-inflammatory responses, but little known about the potential consequences on health disease risk. Importantly, exposure during critical stages of may increase risk later in life. Thus, we hypothesized that developmental will affect inflammation alveolar/airway a sex-dependent manner. To address this knowledge gap, timed pregnant Balb/cJ dams were orally dosed (1.0 or 2.0 mg/kg/d) injected mealworm vehicle control daily from gestational day (GD) 0.5 to postnatal (PND) 21, offspring sacrificed at PND 22-23. PFOS-exposed male displayed increased alveolar septa thickness. Occludin was also downregulated lungs after mice, indicative barrier dysfunction. BALF macrophages significantly elevated mg/kg/d both sexes compared vehicles, whereas cytokines (TNF-α, IL-6, KC, MIP-1α, MIP-1β, MCP-1) suppressed controls. Multiplex nucleic hybridization assay showed male-specific downregulation cytokine gene expression mice mice. Overall, these results demonstrate exhibits adverse effects juvenile offspring, possibly predisposing them later-in-life disease. Further research required elucidate mechanisms underlying sex-differentiated pulmonary toxicity PFOS.

Язык: Английский

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Association Between Prenatal Exposure to Per‐ and Poly‐Fluoroalkyl Substances From Electronic Waste Disassembly Areas and Steroid Hormones in Human Milk Samples

GeoHealth, Год журнала: 2024, Номер 8(8)

Опубликована: Авг. 1, 2024

Abstract Per‐ and poly‐fluoroalkyl substances (PFAS), which are long‐lasting environmental contaminants that released into the environment during e‐waste disassembly process, pose a threat to human health. Human milk is complex dynamic mixture of endogenous exogenous substances, including steroid hormones PFAS. Therefore, in this study, we aimed investigate association between PFAS from women living close an area. In 2021, collected samples 150 mothers within 4 weeks delivery analyzed them via liquid chromatography‐tandem mass spectrometry determine levels 21 perfluorinated compounds five (estrone, estriol, testosterone, progesterone, androstenedione [A‐dione]). We also performed multiple linear regression analysis clarify maternal exposure hormone concentrations. Our results indicated PFOA PFOS were positively associated with estrone ( β , 0.23; 95% CI, 0.08–0.39) A‐dione 0.186; 0.016–0.357) concentrations milk, respectively. Further, average estimated daily intake 36.5 ng/kg bw/day (range, 0.52–291.7 bw/day) 5.21 0.26–32.3 bw/day), Of concern, breastfeeding infants study area was higher than recommended threshold. These findings suggested prenatal process can influence milk. Increased efforts mitigate mother infant pollutants required.

Язык: Английский

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Early-life exposure to per- and polyfluoroalkyl substances and infant gut microbial composition

Environmental Epidemiology, Год журнала: 2022, Номер 7(1), С. e238 - e238

Опубликована: Дек. 14, 2022

Background: Human milk is rich in essential nutrients and immune-activating compounds but also a source of toxicants including per- polyfluoroalkyl substances (PFAS). Evidence suggests that immune-related effects PFAS may, part, be due to alterations the microbiome. We aimed identify association between exposure infant gut Methods: [perfluorooctane sulfonic acid (PFOS) perfluorooctanoate (PFOA)] were quantified from ~6 weeks postpartum using high-performance liquid chromatography with tandem mass spectrometry. A molar sum (ΣPFAS) was calculated. Caregivers collected stool samples at 6 (n = 116) and/or 1 year 119). Stool DNA underwent metagenomic sequencing. estimated diversity relative abundances species linear regression. Single- multi-PFAS models adjusted for potential confounders complete case analyses imputed missing covariate data 6-week 1-year microbiomes separately. assessed sensitive populations stratification. Results: PFOS PFOA detected 94% 83% samples, respectively. associated increased among infants fed exclusively human [β 0.24 per doubling, (95% CI 0.03, 0.45), P 0.03] born primiparous mothers 0.37 (0.06, 0.67), 0.02]. Estimates strongest cases. ΣPFAS Bacteroides vulgatus abundance [(β –2.34% doubling (–3.63, –1.05), FDR q 0.099]. Conclusions: may increase microbiome alter biologically relevant bacteria. Additional related health outcomes.

Язык: Английский

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