Analytical Letters,
Год журнала:
2024,
Номер
57(17), С. 2813 - 2829
Опубликована: Янв. 18, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
known
to
bioaccumulate
in
aquatic
organisms,
such
as
shellfish,
have
been
linked
adverse
human
health
outcomes.
Increasing
attention
has
focused
on
method
development
for
the
detection
of
PFAS
various
media;
however,
these
methods
typically
tedious,
require
high
solvent
volumes,
time
consuming.
The
present
used
a
Quick,
Easy,
Cheap,
Effective,
Rugged,
Safe
(QuEChERS)
extraction
approach
analysis
by
ultra-performance
liquid
chromatography
coupled
with
tandem
mass
spectrometry
(UPLC-MS/MS)
detect
28
Eastern
oyster
(Crassostrea
virginica)
tissue.
This
was
validated
using
limit
detection,
quantitation,
precision
accuracy
studies.
Limits
ranged
from
0.2
5.8
ng
g−1,
limits
quantitation
0.66
19.2
recoveries
spanned
52.1–105.9%
at
100
mL−1
analyte
level.
Analysis
12
unknown
composite
samples
revealed
PFHxA,
PFPeS,
PFOA,
PFHpA
PFOS
least
two
compounds
were
detected
each
sample.
proved
be
an
efficient
environmentally
friendly
sample
preparation
complex
tissue
media,
oysters.
Environmental Research,
Год журнала:
2023,
Номер
238, С. 117234 - 117234
Опубликована: Окт. 2, 2023
Prenatal
exposure
to
metals/metalloids,
even
at
common
US
population
levels,
may
pose
risks
fetal
health,
and
affect
children's
lung
function.
Yet,
the
combined
effects
of
simultaneous
prenatal
exposures
on
function
remain
largely
unexplored.
This
study
analyzed
11
metals
(As
speciation,
Cd,
Co,
Cu,
Mo,
Ni,
Pb,
Sb,
Se,
Sn,
Zn)
in
maternal
urine
during
weeks
24-28
gestation
evaluated
function,
including
forced
vital
capacity
(FVC)
expiratory
volume
first
second
expiration
(FEV1),
316
mother-child
pairs
around
age
7.
We
used
Bayesian
Kernel
Machine
Regression
(BKMR),
weighted
quantile
sum
regression
(WQSR),
multiple
linear
examine
association
between
metal
mixture
adjusting
for
smoking,
child
age,
sex,
height.
In
BKMR
models
assessing
effects,
limited
evidence
non-linearity
or
interactions
was
found.
Nevertheless,
As
species,
Pb
showed
a
negative
association,
while
Mo
exhibited
positive
with
FVC
FEV1,
other
held
constant
their
medians.
The
index,
from
WQSR
analysis
cumulative
impact
all
metals,
highlighted
highest
weight,
As,
Sb
most
substantial
weights
FEV1.
Urinary
Co
were
negatively
associated
(β
=
-0.09,
95%
confidence
interval
(CI)
(-0.18;
-0.01)
β
-0.07,
CI
(-0.13;
0.00),
respectively).
also
FEV1
0.00).
There
FVC,
both
though
wide
intervals.
Our
findings
suggest
that
trace
element
emphasizing
importance
reducing
toxic
maintaining
adequate
nutrient
levels.
Environment International,
Год журнала:
2023,
Номер
181, С. 108271 - 108271
Опубликована: Окт. 18, 2023
The
etiology
of
autism
spectrum
disorder
(ASD)
is
multifactorial,
involving
genetic
and
environmental
contributors
such
as
endocrine-disrupting
chemicals
(EDCs).To
evaluate
the
association
between
perinatal
exposure
to
27
potential
EDCs
ASD
among
Norwegian
children,
further
examine
neurodevelopmental
toxicity
associated
using
zebrafish
embryos
larvae.1,199
mothers
enrolled
in
prospective
birth-cohort
(HUMIS,
2002-2009)
study.
Breastmilk
levels
were
measured:
polychlorinated
biphenyls,
organochlorine
pesticides,
polybrominated
diphenyl
ethers,
perfluoroalkyl
substances
a
proxy
for
exposure.
We
employed
multivariable
logistic
regression
determine
association,
utilized
elastic
net
variable
selection
method,
conducted
an
vivo
study
with
larvae
confirm
effect.A
total
20
children
had
specialist
confirmed
diagnosis
1,199
mother-child
pairs
this
β-Hexachlorocyclohexane
(β-HCH)
was
only
chemical
ASD,
after
adjusting
26
other
chemicals.
Mothers
highest
β-HCH
their
milk
significant
increased
risk
having
child
(OR
=
1.82,
95
%
CI:
1.20,
2.77
interquartile
range
increase
ln-transformed
concentration).
median
concentration
breast
4.37
ng/g
lipid
(interquartile
range:
2.92-6.47),
estimated
daily
intake
(EDI)
through
breastfeeding
0.03
µg/kg
body
weight.
social
behavioral
effects
established
across
various
concentrations,
analysis
suggesting
that
perturbation
dopaminergic
neuron
development
may
underlie
neurotoxicity
β-HCH.Prenatal
specialist-confirmed
diagnoses
EDI
surpasses
threshold.
Zebrafish
experiments
neurotoxicity,
disruption
underlying
mechanism.
Analytical Letters,
Год журнала:
2024,
Номер
57(17), С. 2813 - 2829
Опубликована: Янв. 18, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
known
to
bioaccumulate
in
aquatic
organisms,
such
as
shellfish,
have
been
linked
adverse
human
health
outcomes.
Increasing
attention
has
focused
on
method
development
for
the
detection
of
PFAS
various
media;
however,
these
methods
typically
tedious,
require
high
solvent
volumes,
time
consuming.
The
present
used
a
Quick,
Easy,
Cheap,
Effective,
Rugged,
Safe
(QuEChERS)
extraction
approach
analysis
by
ultra-performance
liquid
chromatography
coupled
with
tandem
mass
spectrometry
(UPLC-MS/MS)
detect
28
Eastern
oyster
(Crassostrea
virginica)
tissue.
This
was
validated
using
limit
detection,
quantitation,
precision
accuracy
studies.
Limits
ranged
from
0.2
5.8
ng
g−1,
limits
quantitation
0.66
19.2
recoveries
spanned
52.1–105.9%
at
100
mL−1
analyte
level.
Analysis
12
unknown
composite
samples
revealed
PFHxA,
PFPeS,
PFOA,
PFHpA
PFOS
least
two
compounds
were
detected
each
sample.
proved
be
an
efficient
environmentally
friendly
sample
preparation
complex
tissue
media,
oysters.
