Exposure to complex mixtures of urban sediments containing Tyre and Road Wear Particles (TRWPs) increases the germ-line mutation rate in Chironomus riparius

Aquatic Toxicology, Год журнала: 2025, Номер 281, С. 107292 - 107292

Опубликована: Фев. 16, 2025

Tyre and road wear particles (TRWPs) are a significant yet often underestimated source of environmental pollution, contributing to the accumulation microplastics complex mixture contaminants in both terrestrial aquatic ecosystems. Despite their prevalence, long-term evolutionary effects TRWPs, beyond immediate toxicity, remain largely unknown. In this study, we assessed mutagenicity non-biting midge Chironomus riparius, upon exposure urban sediment collected from runoff sedimentation basin. To assess extent mutagenic over multiple generations, combined model with short-term mutation lines (MALs) subsequent whole genome sequencing (WGS). The study was conducted five concentrations 0.5 % 10 %. Our results reveal that significantly increases rates compared control groups by 50 %, independent concentration (0.5 %). infer potential causal processes, comparative analysis using known mutational spectra previous studies. This comparison showed profiles induced clearly clustered those caused Benzo[a]Pyrene (BaP), Polycyclic Aromatic Hydrocarbon (PAH). A comprehensive chemical characterization confirmed considerable impact traffic-related contamination, including PAHs primarily petrogenic origin. suggests PAH-like compounds present sediments may play role observed effects. shows influence alter exposed organisms, potentially compromising genomic stability shaping trajectories. These genetic changes can have profound on population dynamics ecosystem health, underlining importance understanding consequences pollution. Additionally, show comparatively analysing provide valuable insights into processes.

Язык: Английский

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Occurrence and Ecological Risk of Alkylamine Triazines in Chinese Estuarine Sediments: An Emerging Class of Persistent, Mobile, and Toxic Substances

Environmental Science & Technology, Год журнала: 2024, Номер 58(15), С. 6814 - 6824

Опубликована: Апрель 6, 2024

Identifying persistent, mobile, and toxic (PMT) substances from synthetic chemicals is critical for chemical management ecological risk assessment. Inspired by the triazine analogues (e.g., atrazine melamine) in original European Union's list of PMT substances, occurrence compositions alkylamine triazines (AATs) estuarine sediments main rivers along eastern coast China were comprehensively explored an integrated strategy target, suspect, nontarget screening analysis. A total 44 AATs identified, which 23 confirmed comparison with authentic standards. Among remaining tentatively identified analogues, 18 emerging pollutants not previously reported environment. Tri- di-AATs dominant varied geographic distributions apparent investigated regions. Toxic unit calculations indicated that there acute chronic risks to algae on a large geographical scale, antifouling biocide cybutryne as key driver. The assessment physicochemical properties further revealed more than half could be categorized potential very persistent mobile at level. These results highlight are class posing high impacts aquatic environment therefore require attention.

Язык: Английский

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Mind your tyres: The ecotoxicological impact of urban sediments on an aquatic organism

The Science of The Total Environment, Год журнала: 2024, Номер 951, С. 175597 - 175597

Опубликована: Авг. 17, 2024

The presence of tyre and road wear particles (TRWP) in the environment is an underestimated threat due to their potential impact on ecosystems human health. However, mode action impacts aquatic remain largely unknown. In present study, we adopted a sediment exposure scenario investigate influence coming from urban runoff sedimentation basin life cycle Chironomus riparius. Targeted broad-spectrum chemical analysis helped characterise sediments confirmed significant contribution contaminants traffic (e.g. contribution, Polycyclic Aromatic Hydrocarbons [PAHs], metals, rubber additives). First-stage chironomid larvae were subjected increasing concentrations whole sediment. results showed that this influenced all measured endpoints. vivo quantification ROS exposed lowest concentration contaminated exhibited increased fluorescence. conditions mortality by almost 30 %, but effect was surprisingly not concentration-dependent. Fertility decreased significantly concentration-dependently. Mean Emergence Time (EmT50) larval size optimality curve. Furthermore, as consequence effects fitness, Population Growth Rate (PGR) decrease, which Therefore, after single generation, PGR calculation can be sensitive tool monitor pollution caused complex matrices, i.e. composed several contaminants. Our research highlights importance effective management underlines need for further investigation better understand toxicity TRWPs.

Язык: Английский

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Ubiquitous occurrence of p-Phenylenediamine (PPD) antioxidants and PPD-quinones in fresh atmospheric snow and their amplification effects on associated aqueous contamination

Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133409 - 133409

Опубликована: Дек. 30, 2023

Язык: Английский

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Urban sewage discharge of neonicotinoids and their transformation products threatens aquatic organisms

Water Research, Год журнала: 2024, Номер 268, С. 122740 - 122740

Опубликована: Ноя. 2, 2024

Язык: Английский

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Occurrence and phase distribution of benzothiazoles in untreated highway stormwater runoff and road dust

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(49), С. 107878 - 107886

Опубликована: Сен. 23, 2023

Язык: Английский

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Examination of interactions between heavy metals and benzotriazoles in rainwater runoff and snowmelt in an urban catchment in Poland

Water Resources and Industry, Год журнала: 2023, Номер 31, С. 100236 - 100236

Опубликована: Дек. 7, 2023

Heavy metals (HMs) are toxic pollutants that can accumulate and harm human health the environment. Monitoring their concentration in water is an essential tool for evaluating quality safety of this vital resource. The aims study were (i) to characterize HMs contamination rainwater runoff snowmelt, identify likely sources compliance with regulations guidelines, (ii) conduct a preliminary assessment regarding potential link between occurrence benzotriazoles based on previous experiment. This investigates six (cadmium, lead, nickel, chromium, copper, zinc) snowmelt samples collected twelve Białystok locations northeastern Poland. highest Cu (517.5 μg/L) was identified from city's ring road, heavy vehicle traffic, near industrial area. A 4-lane asphalt street city center exhibited concentrations Pb (91.1 Ni (64.6 also Cd (1.37 (27.3 runoff. sample pedestrian-only area presented Zn (3672.2 μg/L). Considerable contents Cr (353.2 found warehousing Snowmelt higher than Our results indicate most occur independently. analysis winds tendency travel dust particles suggest specific contaminants might have originated Belarus, neighboring territory Białystok.

Язык: Английский

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Seasonal hot spots of pollution and risks in Western Kenya: A spatial-temporal analysis of almost 800 organic micropollutants

The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 175036 - 175036

Опубликована: Июль 27, 2024

The release of chemicals into the environment presents a significant threat to aquatic ecosystems dependent on proximity emission sources and seasonal dynamics mobilization. While spatial-temporal information water pollution in Europe is increasing, there are substantial knowledge gaps tropical countries. Thus, we took Lake Victoria South Basin western Kenya as case study identify spatial hot spots contamination, quantified toxic risks different groups organisms, identified risk drivers. For this purpose, analyzed grab samples from five rivers with agricultural wastewater treatment plants their catchment four seasons. We used liquid chromatography coupled high resolution mass spectrometry (LC-HRMS) target list 785 organic micropollutants. A total 307 compounds were detected concentrations ranging 0.3 ng/L 6.6 μg/L. Using Toxic Unit (TU) approach based mixture toxicity standard test crustaceans most affected group followed by algae fish. crustaceans, chronic thresholds exceeded 96 % all samples, while 56 expected be acutely toxic, highest February during dry season. High unit values for fish recorded July season May wet Diazinon, imidacloprid, clothianidin pirimiphos-methyl major drivers crustacean triclosan herbicide mixtures drive seasons, respectively. 18 found exceed acute environmental thresholds. With study, strong patterns pollution, could confirmed informing prioritization monitoring abatement enhance quality reduce risks.

Язык: Английский

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Long-Term Exposure to Tire-Derived 6-PPD Quinone Causes Neurotoxicity and Neuroinflammation via Inhibition of HTR2A in C57BL/6 Mice

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), a novel contaminant derived from tire wear, has raised concerns due to its potential neurotoxicity, yet long-term effects on mammalian neurological health remain poorly understood. This study investigates the neurotoxic and neuroinflammatory impacts of prolonged 6-PPDQ exposure using male C57BL/6 mice. Behavioral assessments revealed significant cognitive deficits, while biochemical analyses demonstrated increased levels reactive oxygen species, apoptosis, blood-brain barrier (BBB) disruption. Elevated pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) activation microglial cells were observed, indicating robust response. Network pharmacology molecular docking identified serotonin receptor HTR2A as key target through which mediates toxic effects. Activation by agonist DOI (2,5-dimethoxy-4-iodoamphetamine) mitigated these effects, suggesting therapeutic strategy. These findings provide first evidence 6-PPDQ-induced neurotoxicity in mammals, underscoring need for preventive measures protect health.

Язык: Английский

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Following the Mixtures of Organic Micropollutants with In Vitro Bioassays in a Large Lowland River from Source to Sea

ACS Environmental Au, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Язык: Английский

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