Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study DOI Creative Commons
Ugonna Ihenacho, Cherie Guillermo, Lynne R. Wilkens

и другие.

Journal of the Endocrine Society, Год журнала: 2023, Номер 7(12)

Опубликована: Ноя. 2, 2023

Metabolic syndrome (MetS) is associated with a high risk of cardiovascular disease, leading cause death among women. MetS diagnosis at least 3 the following: blood pressure, fasting glucose, triglycerides, waist circumference, and low high-density lipoprotein cholesterol. Epidemiological studies suggest that endocrine disrupting chemical (EDC) exposure positively individual components MetS, but evidence an association between EDCs remains inconsistent. In cross-sectional analysis within Multiethnic Cohort Study, we evaluated 4 classes urinary (bisphenol A [BPA], triclosan, parabens, phthalates) 1728 Multivariable logistic regression was used to estimate odds ratios 95% CI for tertiles each EDC adjusting age, body mass index (BMI), racial ethnic group, breast cancer status. Stratified analyses by race ethnicity BMI were conducted. identified in 519 (30.0%) We did not detect statistically significant associations BPA, or phthalate metabolite excretion. inversely total parabens (Ptrend = .002). Although there suggestive inverse Latino African American women, women < 30 kg/m2, no heterogeneity BMI. These findings larger multiethnic studies. Prospective investigate suggested differences race, ethnicity, are warranted.

Язык: Английский

AQP1 Deficiency Drives Phthalate-Induced Epithelial Barrier Disruption through Intestinal Inflammation DOI
Yi Zhao,

Zi-Yan Hu,

Ming Lou

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(27), С. 15334 - 15344

Опубликована: Июнь 25, 2024

Di-2-ethylhexyl phthalate (DEHP) is frequently used as a plasticizer to enhance the plasticity and durability of agricultural products, which pose adverse effects human health environment. Aquaporin 1 (AQP1) main water transport channel protein involved in maintenance intestinal integrity. However, impact DEHP exposure on gut its potential mechanisms remain elusive. Here, we determined that induced compromised duodenum structure, was concomitant with mitochondrial structural injury epithelial cells. Importantly, caused inflammatory cell damage strong response accompanied by activating TLR4/MyD88/NF-κB signaling pathway. Mechanistically, directly inhibits expression AQP1 thus leads an response, ultimately disrupting integrity barrier function. Collectively, our findings uncover role phthalate-induced disorders, could be promising therapeutic approach for treating patients disorders or diseases.

Язык: Английский

Процитировано

14
Enhancing SERS Sensitivity in N‐Graphene Hydrangea by Synergistic Charge‐Transfer and Excitation Light Absorption DOI Creative Commons
Bingkun Wang, Zheng Li,

Huijuan Wu

и другие.

Small Structures, Год журнала: 2024, Номер 5(3)

Опубликована: Янв. 14, 2024

Surface‐enhanced Raman scattering (SERS) is a versatile spectroscopic technique, which plays crucial role in enhancing analytical sensitivity, investigating interfacial reaction mechanisms, enabling biosensing, and fostering efficient catalysis. Currently, the common SERS substrates are primarily metal nanostructures, entail high manufacturing costs, complex processes, surface undergo change over time with environmental conditions. These issues limit development of technology. In this work, nitrogen‐doped graphene (N‐graphene) hydrangea was synthesized on silicon (Si) substrate using plasma‐assisted chemical vapor deposition (PACVD), forming an N‐graphene hydrangea/Si hybrid structure as substrate. This offers advantages stability, ultra‐sensitivity, reusability. The three‐dimensional nano‐cavity can increase interaction between light graphene, resulting increased localized electric field. Combining theoretical simulation analysis, introduction nitrogen (N) elements adjusts Fermi level promoting charge transfer. practical scenarios, Di(2‐ethylhexyl) phthalate (DEHP), commonly used plasticizer, has raised concerns due to its potential endocrine disruptor carcinogen. as‐prepared achieves remarkable detection low 10 −8 m for DEHP, providing significant support conservation human health.

Язык: Английский

Процитировано

7
Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness DOI Open Access
Somayeh Vafaei, Samar Alkhrait, Qiwei Yang

и другие.

Nutrients, Год журнала: 2024, Номер 16(6), С. 807 - 807

Опубликована: Март 12, 2024

Uterine fibroids (UFs) are the most common prevalent benign tumor among women of reproductive age, disproportionately affecting color. This paper introduces an innovative management strategy for UFs, emphasizing curbing disease prevention and progression. Traditionally, medical intervention is deferred until advanced stages, necessitating invasive surgeries such as hysterectomy or myomectomy, leading to high recurrence rates increased healthcare costs. The strategy, outlined in this review, emphasizes UF named LIFE UP awareness—standing Lifestyle Interventions, Food Modifications, Environmental Practices Prevention. These cost-effective, safe, accessible measures hold potential prevent improve overall health, reduce need procedures, generate substantial cost savings both individuals systems. review underscores importance a proactive method, paving way future research policy initiatives domain.

Язык: Английский

Процитировано

3
Investigation on the interaction between catalase and typical phthalates with different side chain lengths DOI
Rui Guan, Yaoyao Wang, Hongbin Liu

и другие.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер 336, С. 126031 - 126031

Опубликована: Март 12, 2025

Язык: Английский

Процитировано

0
Dibutyl phthalate promotes central precocious puberty through primordial follicle activation by downregulating BMP15 DOI
Yangcheng Yao, Wenjuan Liu,

Maoxing Tang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 300, С. 118460 - 118460

Опубликована: Июнь 4, 2025

Язык: Английский

Процитировано

0
Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort DOI Creative Commons
Vicente Mustieles,

Aurélien Lascouts,

Óscar J. Pozo

и другие.

Environmental Science & Technology, Год журнала: 2023, Номер 57(48), С. 19202 - 19213

Опубликована: Ноя. 6, 2023

We assessed phthalate-hormone associations in 382 pregnant women of the new-generation SEPAGES cohort (2014–2017, France) using improved exposure and outcome assessments. Metabolites from seven phthalate compounds replacement di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) were measured within-subject pools repeated urine samples collected at second third pregnancy trimesters (≈21 samples/trimester). five steroid hormones maternal hair delivery, reflecting cumulative levels over previous weeks to months. Adjusted linear regression Bayesian weighted quantile sum (BWQS) mixture models performed. Each doubling third-trimester urinary mono-benzyl (MBzP) concentrations was associated with an average increase 13.3% (95% CI: 2.65, 24.9) for ∑cortisol, 10.0% 0.26, 20.7) ∑cortisone, 17.3% 1.67, 35.4) 11-dehydrocorticosterone, 16.2% 2.20, 32.1) testosterone, together a suggestive 10.5% −1.57, 24.1) progesterone levels. second-trimester di-isononyl (DiNP) inversely testosterone (−11.6%; 95% −21.6, −0.31). For most hormones, nonsignificant trend toward positive effect observed but not trimester. Our study showed that some metabolites, especially MBzP, may affect adrenal reproductive hormone during pregnancy.

Язык: Английский

Процитировано

8
Thyroid hormones and oxidative stress moderated the association between urinary phthalate metabolites and cardiovascular risk factors DOI
Rong He,

Hua Bi,

Jia He

и другие.

Environmental Pollution, Год журнала: 2024, Номер 362, С. 124927 - 124927

Опубликована: Сен. 13, 2024

Язык: Английский

Процитировано

2
Bacterial Catabolism of Phthalates With Estrogenic Activity Used as Plasticisers in the Manufacture of Plastic Products DOI Creative Commons
Rinita Dhar,

Suman Basu,

Mousumi Bhattacharyya

и другие.

Microbial Biotechnology, Год журнала: 2024, Номер 17(11)

Опубликована: Ноя. 1, 2024

ABSTRACT Phthalic acid esters (PAEs), the pervasive and ubiquitous endocrine‐disrupting chemicals of environmental concern, generated annually on a million‐ton scale, are primarily employed as plasticisers in production variety plastic products additives large number commercial supplies. The increased awareness various adverse effects ecosystem human health including reproductive developmental disorders has led to striking increase research interest aimed at managing these man‐made oestrogenic chemicals. In circumstances, microbial metabolism appeared major realistic process neutralise toxic burdens PAEs an ecologically accepted manner. Among wide species capable degrading/transforming reported so far, bacteria‐mediated degradation been studied most extensively. main purpose this review is provide current knowledge metabolic imprints degradation/transformation PAEs, co‐contaminant pollution. addition, communication illustrates recent advancement structure–functional aspects key enzyme phthalate hydrolase, their inducible regulation gene expression evolutionary relatedness, besides prioritising future needs facilitate development new insights into bioremediation PAE environment.

Язык: Английский

Процитировано

2
Silicone wristbands reveal ubiquitous human exposure to ortho-phthalates and non-ortho-phthalate plasticizers in Southern California DOI
Aalekhya Reddam, Nicholas J. Herkert, Heather M. Stapleton

и другие.

Environmental Research, Год журнала: 2024, Номер 258, С. 119465 - 119465

Опубликована: Июнь 21, 2024

Язык: Английский

Процитировано

1
Dose Addition Models Accurately Predict the Subacute Effects of a Mixture of Perfluorooctane Sulfonate and Perfluorooctanoic Acid on Japanese Quail (Coturnix japonica) Chick Mortality DOI Creative Commons
L. Earl Gray, Justin M. Conley, Steven J. Bursian

и другие.

Environmental Toxicology and Chemistry, Год журнала: 2023, Номер 43(1), С. 97 - 104

Опубликована: Сен. 27, 2023

Biomonitoring data have consistently demonstrated that fish, wildlife, and humans are exposed to multiple per- polyfluoroalkyl substances (PFAS) in drinking water foods. Despite ubiquitous exposure mixtures of PFAS, there is a lack vivo PFAS mixture research addresses whether these chemicals act cumulative, dose-additive (DA) manner or they behave independently. For this reason, critical need for studies designed evaluate the cumulative toxicity potential chemical interactions support assessment human ecological risks also define appropriate regulatory actions. Our primary objective was previously published Japanese quail chick mortality concentration-response perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), PFOS + PFOA use statistical modeling determine effects were accurately predicted by either DA response addition modeling. In addition, we wanted compare different models one model produced more accurate predictions than others. results hypothesis on shared endpoints from co-exposure approaches predictive estimates effects. Given limited number been executed with enough individual test mixtures, re-analysis an important contribution our understanding how act. The analysis will provide agencies as begin implement hazard assessments higher vertebrates. Environ Toxicol Chem 2024;43:97-104. © 2023 SETAC. This article has contributed U.S. Government employees their work public domain USA.

Язык: Английский

Процитировано

3