Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice

Journal of Hazardous Materials, Год журнала: 2024, Номер 470, С. 134165 - 134165

Опубликована: Март 28, 2024

Язык: Английский

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Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation

The Science of The Total Environment, Год журнала: 2024, Номер 918, С. 170679 - 170679

Опубликована: Фев. 5, 2024

Язык: Английский

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Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 472, С. 134598 - 134598

Опубликована: Май 13, 2024

Язык: Английский

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Polystyrene nanoparticles strengthen high glucose toxicity associated with alteration in insulin signaling pathway in C. elegans

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 272, С. 116056 - 116056

Опубликована: Фев. 1, 2024

Using Caenorhabditis elegans as animal model, we investigated the effect of exposure to polystyrene nanoparticles (PS-NPs) in range μg/L on high glucose toxicity induction. With lifespan and locomotion behavior endpoints, observed that PS-NP (10 100 μg/L) enhanced 50 mM treated animals. In insulin signaling pathway, expressions genes encoding receptor (daf-2), kinases (age-1 akt-1/2), peptides (ins-9, ins-6, daf-28) were increased, daf-16 its target sod-3 decreased nematodes followed by exposure. Toxicity enhancement was inhibited RNAi daf-2, age-1, akt-2, akt-1, 3 genes, but increased sod-3. The resistance animals with daf-2 could be suppressed daf-16. Moreover, exposure, expression ins-9, daf-28. Our data demonstrated risk enhancing toxicity. More importantly, alteration pathway associated

Язык: Английский

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Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans

Environmental Pollution, Год журнала: 2023, Номер 337, С. 122649 - 122649

Опубликована: Сен. 28, 2023

Язык: Английский

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Exposure to 6-PPD quinone enhances lipid accumulation through activating metabolic sensors of SBP-1 and MDT-15 in Caenorhabditis elegans

Environmental Pollution, Год журнала: 2023, Номер 333, С. 121937 - 121937

Опубликована: Июнь 10, 2023

Язык: Английский

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6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding

Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133312 - 133312

Опубликована: Дек. 19, 2023

Язык: Английский

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A mini review on 6PPD quinone: A new threat to aquaculture and fisheries

Environmental Pollution, Год журнала: 2023, Номер 340, С. 122828 - 122828

Опубликована: Окт. 29, 2023

Язык: Английский

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Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout

Science Bulletin, Год журнала: 2023, Номер 69(5), С. 621 - 635

Опубликована: Дек. 26, 2023

Язык: Английский

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Polyethylene nanoplastics cause reproductive toxicity associated with activation of both estrogenic hormone receptor NHR-14 and DNA damage checkpoints in C. elegans

The Science of The Total Environment, Год журнала: 2023, Номер 906, С. 167471 - 167471

Опубликована: Сен. 29, 2023

Язык: Английский

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