Associations between phenol and paraben exposure and the risk of developing breast cancer in adult women: a cross-sectional study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 3, 2025

Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) have adverse effects on breast cancer (BC). The aim of this study was to assess the association between exposure prevalent EDCs—phenols and parabens—and risk developing BC. Data urinary bisphenol A (BPA), triclosan (TRS), benzophenone-3 (BP3), methyl paraben (MPB), ethyl (EPB), propyl (PPB), butyl (BUP) were obtained from 2005–2014 National Health Nutrition Examination Survey. total 4455 subjects included in cross-sectional study. results weighted multivariable regression models indicated elevated concentrations TRS increased BC by 2.33 (Q2: 95% CI = 1.45–3.75, p < 0.001) 1.94 times (Q3: 1.21–3.09, 0.006), respectively. nonlinear statistically significant (P 0.007), with restricted cubic splines (RCS) curve exhibiting an inverted U shape. more pronounced among overweight individuals (BMI ≥ 25 kg/m2), those aged 60 years, white individuals. Weighted quantile sum (WQS) Bayesian Kernel Machine Regression (BKMR) analysis revealed no overall mixtures phenol metabolites risk. However, most influential, higher (both continuous categorical) significantly associated risk, particularly

Язык: Английский

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Metabolomics and Lipidomics with Mass Spectrometry Imaging Reveal Mechanistic Insights into Dibutyl Phthalate-Promoted Proliferation of Breast Cancer Cell Spheroids

Environmental Science & Technology Letters, Год журнала: 2024, Номер 11(3), С. 208 - 215

Опубликована: Март 1, 2024

Dibutyl phthalate (DBP), extensively used as a plasticizer, has endocrine-disrupting properties that may increase the risk of breast cancer at low concentrations. However, previous studies on effects DBP mainly focused activation typical intracellular receptors, and downstream mechanisms metabolic level have not been well elucidated. Therefore, our study applied metabolomics, lipidomics, mass spectrometry imaging (MSI) techniques to investigate responses MCF-7 cell spheroid (CCS) exposure. The omics results showed exposure resulted in increased glucose glutamine uptake catabolism CCS which supported production nucleotides, glycerophospholipids, amino acids, providing sufficient energy building blocks for synthesis DNA/RNA cytomembrane necessary proliferation. These were further corroborated by MSI data, showing enhanced abundances ATP, GMP, UDP, lysophosphatidylcholines, phosphatidylcholines, phosphatidylethanolamines treated with DBP. Interestingly, most these biomolecules predominantly distributed proliferative region. Our result indicated supply biosynthetic substrates peripheral area facilitated proliferation CCS, shedding new light DBP-promoted development.

Язык: Английский

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Spatial Lipidomics Reveals Lipid Changes in the Cotyledon and Plumule of Mung Bean Seeds during Germination

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(49), С. 19879 - 19887

Опубликована: Ноя. 29, 2023

Seed germination is a vital process in plant development involving dynamic biochemical transformations such as lipid metabolism. However, the spatial distribution and changes of lipids different seed compartments during are poorly understood. In this study, we employed liquid chromatography/mass spectrometry (LC/MS)-based lipidomics MALDI mass imaging (MSI) to investigate occurring cotyledon plumule mung bean seeds germination. Lipidomic data revealed that reduced levels many glycerolipids (e.g., triglyceride) phosphatidylglycerols phosphatidylcholine) while increased lysophospholipids lysophosphatidylcholine) both plumule. Sphingolipids sphingomyelin) displayed altered solely Sterol but decreased Further results MALDI–MSI could serve supplement validate LC–MS data. These findings enhance our understanding metabolic processes underlying seedling development, with potential implications for crop improvement quality control.

Язык: Английский

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Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(11), С. 101024 - 101024

Опубликована: Июнь 26, 2024

Triclocarban (TCC) is a common antimicrobial agent that has been widely used in medical care. Given the close association between TCC treatment and metabolic disorders, we assessed whether long-term to at human-relevant concentration could induce nephrotoxicity by disrupting levels mouse model. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was applied investigate alterations spatial distributions abundances of TCC, endogenous exogenous metabolites kidney after treatment. The results showed induced changes organ weight, coefficient histopathology kidney. MSI data reveled accumulated all regions kidney, while its five mainly distributed cortex regions. 79 biomolecules associated with pathways leukotriene E4 metabolism, biosythesis degradation glycerophospholipids glycerolipids, ceramide-to-sphingomyelin signaling were significantly altered These distinctive displayed favorable correlation pathological damage. This work offers new insights into related mechanisms TCC-induced nephrotocicity exhibits potential MALDI-MSI-based metabolomics as promising approach for risk assessment agents

Язык: Английский

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Toxicity evolution of triclosan during environmental transformation and human metabolism: Misgivings in the post-pandemic era

Environment International, Год журнала: 2024, Номер 190, С. 108927 - 108927

Опубликована: Авг. 1, 2024

In the context of pandemic viruses and pathogenic bacteria, triclosan (TCS), as a typical antibacterial agent, is widely used around world. However, health risks from TCS increase with exposure, it widespread in environmental human samples. Notably, transformation metabolism could induce potentially undesirable to humans, rather than simple decontamination or detoxification. This review summarizes exposure covering 2004 2023. Particularly, impacts metabolic are emphasized. Environmental transformations aimed at recognized form carcinogenic products such dioxins, ultraviolet light excessive active chlorine can promote formation these dioxin congeners, threatening health. Although be rapidly metabolized for detoxification, processes lipophilic ether analogs via cytochrome P450 catalysis, causing possible adverse cross-talk reactions disorders. Accordingly, may more harmful metabolism. particular, stimulate transmission antibiotic resistance even trace levels, public Considering accruing epidemiological toxicological studies indicating multiple outcomes TCS, we call on toxicologists pay attention toxicity evolution during

Язык: Английский

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Lipid metabolic reprograming: the unsung hero in breast cancer progression and tumor microenvironment

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Март 3, 2025

Aberrant lipid metabolism is a well-recognized hallmark of cancer. Notably, breast cancer (BC) arises from lipid-rich microenvironment and depends significantly on metabolic reprogramming to fulfill its developmental requirements. In this review, we revisit the pivotal role in BC, underscoring impact progression tumor microenvironment. Firstly, delineate overall landscape highlighting roles patient prognosis. Given that lipids can also act as signaling molecules, next describe exchanges between BC cells other cellular components Additionally, summarize therapeutic potential targeting aspects processes, lipid-related transcription factors immunotherapy BC. Finally, discuss possibilities problems associated with clinical applications lipid‑targeted therapy propose new research directions advances spatiotemporal multi-omics.

Язык: Английский

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Long-term and low-dose exposure to triclosan induces POI phenotype in female offspring mice

Environmental Pollution, Год журнала: 2025, Номер 372, С. 125966 - 125966

Опубликована: Март 3, 2025

Язык: Английский

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Factorial-Design-Based Optimization of a Commercial MALDI-2 timsTOF Mass Spectrometer for Lipid Analysis

Journal of the American Society for Mass Spectrometry, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Matrix-assisted laser desorption/ionization mass spectrometry with postionization (MALDI-2 MS) has become an important technique for the analysis of a wide range biomolecules. It traditionally been limited to custom lab-built setups until recent introduction commercial timsTOF fleX MALDI-2 system. A comprehensive optimization system lipid was performed using factorial design experiments (DOE). By examining 13 instrumental parameters across three full DOEs, we over 1500 individual runs assess impact and cross interactions these on signal intensity. We found optimal values both ion transmission maximize signals within region. These results show that shot frequency, collision RF, pre pulse storage were essential enhancing transmission, resulting in nearly 5-fold increase intensity compared default parameters. For optimization, positive negative modes showed similar optimized values, TIMS In pressure power being crucial. Overall, optics resulted enhancements 2 orders magnitude certain species.

Язык: Английский

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Bifunctional Catalyst ZVI@PDA Mediated the Reduction Coupling Oxidation Reaction of Triclosan to Achieve a High Mineralization Rate

ACS ES&T Water, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Язык: Английский

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The role of artificial intelligence in the development of anticancer therapeutics from natural polyphenols: Current advances and future prospects

Pharmacological Research, Год журнала: 2024, Номер 208, С. 107381 - 107381

Опубликована: Авг. 30, 2024

Natural polyphenols, abundant in the human diet, are derived from a wide variety of sources. Numerous preclinical studies have demonstrated their significant anticancer properties against various malignancies, making them valuable resources for drug development. However, traditional experimental methods developing therapies natural polyphenols time-consuming and labor-intensive. Recently, artificial intelligence has shown promising advancements discovery. Integrating AI technologies into development process can substantially reduce time enhance efficiency. In this study, we review crucial roles treatment explore potential to aid Specifically, discuss application key stages such as structure prediction, virtual screening, prediction biological activity, drug-target protein interaction, highlighting revolutionize polyphenol-based therapies.

Язык: Английский

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