Revolutionizing food science with mass spectrometry imaging: A comprehensive review of applications and challenges

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2024, Номер 23(4)

Опубликована: Июнь 25, 2024

Abstract Food science encounters increasing complexity and challenges, necessitating more efficient, accurate, sensitive analytical techniques. Mass spectrometry imaging (MSI) emerges as a revolutionary tool, offering molecular‐level insights. This review delves into MSI's applications challenges in food science. It introduces MSI principles instruments such matrix‐assisted laser desorption/ionization, desorption electrospray ionization, secondary ion mass spectrometry, ablation inductively coupled plasma highlighting their application chemical composition analysis, variety identification, authenticity assessment, endogenous substance, exogenous contaminant residue quality control, process monitoring processing storage. Despite its potential, faces hurdles the cost of instrumentation, sample preparation, limited capabilities, lack standardization for samples. While has wide range analysis can provide comprehensive accurate results, persist, demanding further research solutions. The future development directions include miniaturization devices, high‐resolution high‐speed MSI, multiomics multimodal data fusion, well artificial intelligence. These findings conclusions valuable references insights field offer theoretical methodological support practice

Язык: Английский

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Spatial metabolomics reveal metabolic alternations in the injured mice kidneys induced by triclocarban treatment

Journal of Pharmaceutical Analysis, Год журнала: 2024, Номер 14(11), С. 101024 - 101024

Опубликована: Июнь 26, 2024

Triclocarban (TCC) is a common antimicrobial agent that has been widely used in medical care. Given the close association between TCC treatment and metabolic disorders, we assessed whether long-term to at human-relevant concentration could induce nephrotoxicity by disrupting levels mouse model. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was applied investigate alterations spatial distributions abundances of TCC, endogenous exogenous metabolites kidney after treatment. The results showed induced changes organ weight, coefficient histopathology kidney. MSI data reveled accumulated all regions kidney, while its five mainly distributed cortex regions. 79 biomolecules associated with pathways leukotriene E4 metabolism, biosythesis degradation glycerophospholipids glycerolipids, ceramide-to-sphingomyelin signaling were significantly altered These distinctive displayed favorable correlation pathological damage. This work offers new insights into related mechanisms TCC-induced nephrotocicity exhibits potential MALDI-MSI-based metabolomics as promising approach for risk assessment agents

Язык: Английский

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Advances in clinical application of lipidomics in healthy ageing and healthy longevity medicine

Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102432 - 102432

Опубликована: Июль 17, 2024

It is imperative to optimise health and healthspan across the lifespan. The accumulation of reactive oxygen species (ROS) has been implicated in hallmarks ageing inhibiting ROS production can potentially delay whilst increasing healthy longevity. Lipids lipid mediators (derivatives lipids) are becoming increasingly recognized as central molecule tissue cellular function susceptible peroxidation; hence linked with ageing. Lipid classes process include sterols, glycerophospholipids, sphingolipids oxidation products polyunsaturated fatty acids but these not yet translated into clinic. Further mechanistic studies required for understanding process. Lipidomics, system level characterisation respect metabolism function, might provide a significant useful biological age profiling tool through longitudinal studies. profiles different ages among individuals could be harnessed biomarkers potential integration development lipid-based clock (lipid clock). includes prediction future morbidity or mortality, which will promote precision longevity medicine.

Язык: Английский

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Factorial-Design-Based Optimization of a Commercial MALDI-2 timsTOF Mass Spectrometer for Lipid Analysis

Journal of the American Society for Mass Spectrometry, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Matrix-assisted laser desorption/ionization mass spectrometry with postionization (MALDI-2 MS) has become an important technique for the analysis of a wide range biomolecules. It traditionally been limited to custom lab-built setups until recent introduction commercial timsTOF fleX MALDI-2 system. A comprehensive optimization system lipid was performed using factorial design experiments (DOE). By examining 13 instrumental parameters across three full DOEs, we over 1500 individual runs assess impact and cross interactions these on signal intensity. We found optimal values both ion transmission maximize signals within region. These results show that shot frequency, collision RF, pre pulse storage were essential enhancing transmission, resulting in nearly 5-fold increase intensity compared default parameters. For optimization, positive negative modes showed similar optimized values, TIMS In pressure power being crucial. Overall, optics resulted enhancements 2 orders magnitude certain species.

Язык: Английский

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Identification of miRNA-mRNA regulatory network during the germination of soybean seed(Glycine max)and the role of Gma-miR1512a-GmKIN10 interaction

Plant Physiology and Biochemistry, Год журнала: 2025, Номер unknown, С. 109853 - 109853

Опубликована: Март 1, 2025

Язык: Английский

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MALDI Mass Spectrometry Imaging of Metabolites in Cereal Grains and Legumes: Repurposing for Industrial Applications

Food Reviews International, Год журнала: 2024, Номер unknown, С. 1 - 22

Опубликована: Дек. 20, 2024

Cereal grains and legumes are major sources of health-promoting nutrients in our daily diet key ingredients food production. However, they also subjected to contamination by foreign substances such as mycotoxins, pesticides, acrylamide. Analytical techniques methods for detecting quantifying metabolites plants mass spectrometry well-established, but disregard spatial information. In contrast, matrix-assisted laser desorption/ionisation imaging (MALDI-MSI) is a powerful technique study the distribution molecules within plant tissues, providing valuable insights into biology physiology. To date, translation this technology industrial applications seldom explored. This review article introduces how MALDI-MSI can revolutionise traditional approaches cereal legumes. The principles typical workflow, particularly sample preparation were discussed. explores previous implementations ag-food research, opportunities it presents seed crop applications. open gates technological advances improve analysis, processing regulatory systems grain legume industry.

Язык: Английский

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Impact of short-term germination on dehulling efficiency, enzymatic activities, and chemical composition of mung bean seeds (Vigna radiata L.)

Future Foods, Год журнала: 2024, Номер 10, С. 100416 - 100416

Опубликована: Июль 14, 2024

Mung beans are promising for protein ingredient production, but their benefits hindered by potential antinutritional factors and coloring compounds in the hull, resulting darker-colored products. To address this issue, study aims to identify a germination period that enhances dehulling efficiency while minimizing mass losses chemical alterations. bean seeds were soaked overnight germinated dark 4, 8, 12, 24, 32, 48 h, with effects on efficiency, enzymatic activities, composition, including factors, examined. After h of germination, substantial increase enzyme activities was observed: lipolytic increased 644 %, amylolytic 200 polyphenol oxidase activity 280 %. A decline (21.02–25.77 %), starch (41.83–56.65 fat (0.35–1.03 %) content detectable after germination. SDS-PAGE analysis revealed reduction globulins structural changes prolonged Total phenolic particularly reduced 20 % due dehulling. Short-term within 12 24 found be an effective strategy facilitate mung reducing preserving thus improving as high-quality raw material plant-based foods.

Язык: Английский

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Comprehensive lipidomic insights of differentially accumulating lipids in large pigmented rice sprout collection and the changes in the starch composition upon germination

Food Chemistry, Год журнала: 2024, Номер 460, С. 140677 - 140677

Опубликована: Июль 31, 2024

Язык: Английский

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MALDI and MALDI-2 mass spectrometry imaging contribute to revealing the alternations in lipid metabolism in germinating soybean seeds

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110595 - 110595

Опубликована: Окт. 1, 2024

Язык: Английский

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Uncovering the multiscale structure and physicochemical properties of starch extracted from naturally fermented mung bean liquid by wet milling

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105298 - 105298

Опубликована: Окт. 1, 2024

Язык: Английский

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