Phytotoxicity of 6PPD and its uptake by Myriophyllum verticillatum: Oxidative stress and metabolic processes DOI

Yuexing Zhao,

Weitao Liu,

Jinzheng Liu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 177248 - 177248

Опубликована: Ноя. 1, 2024

Язык: Английский

Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans DOI
Yingchen Yang, Wei Meng, Ya Zhang

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 5, 2024

There is growing evidence of the frequent detection tire rubber-derived contaminants

Язык: Английский

Процитировано

4
Long-Term Exposure to Tire-Derived 6-PPD Quinone Causes Neurotoxicity and Neuroinflammation via Inhibition of HTR2A in C57BL/6 Mice DOI
Changsheng Ma,

Yuxi Liu,

Bo Han

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), a novel contaminant derived from tire wear, has raised concerns due to its potential neurotoxicity, yet long-term effects on mammalian neurological health remain poorly understood. This study investigates the neurotoxic and neuroinflammatory impacts of prolonged 6-PPDQ exposure using male C57BL/6 mice. Behavioral assessments revealed significant cognitive deficits, while biochemical analyses demonstrated increased levels reactive oxygen species, apoptosis, blood-brain barrier (BBB) disruption. Elevated pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) activation microglial cells were observed, indicating robust response. Network pharmacology molecular docking identified serotonin receptor HTR2A as key target through which mediates toxic effects. Activation by agonist DOI (2,5-dimethoxy-4-iodoamphetamine) mitigated these effects, suggesting therapeutic strategy. These findings provide first evidence 6-PPDQ-induced neurotoxicity in mammals, underscoring need for preventive measures protect health.

Язык: Английский

Процитировано

0
Protective role of ghrelin against 6PPD-quinone-induced neurotoxicity in zebrafish larvae (Danio rerio) via the GHSR pathway DOI Creative Commons
Zhengwei Huang, Congcong Chen,

Kaiyu Guan

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 285, С. 117031 - 117031

Опубликована: Сен. 28, 2024

Язык: Английский

Процитировано

3
Stress of Soil Moisture and Temperature Exacerbates the Toxicity of Tire Wear Particles to Soil Fauna: Tracking the Role of Additives through Host Microbiota DOI
Min Lv, Han Chen,

Zhaoqin Liang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 135995 - 135995

Опубликована: Сен. 28, 2024

Язык: Английский

Процитировано

3
Phytotoxicity of 6PPD and its uptake by Myriophyllum verticillatum: Oxidative stress and metabolic processes DOI

Yuexing Zhao,

Weitao Liu,

Jinzheng Liu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 955, С. 177248 - 177248

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

3