Journal of Hazardous Materials Letters,
Год журнала:
2024,
Номер
5, С. 100109 - 100109
Опубликована: Апрель 3, 2024
Per-
and
polyfluoroalkyl
substances
(PFASs)
have
been
found
in
toilet
paper
Europe,
the
United
States,
Africa;
however,
their
presence
Chinese
household
has
not
investigated.
In
this
study,
21
legacy
30
emerging
PFASs
were
analyzed
tissue
from
China,
including
48
samples
of
different
origins
materials.
Median
concentrations
chlorinated
polyfluorinated
ether
sulfonates
(Cl-PFESAs),
hexafluoropropylene
oxide
homologs
(HFPOs),
p-perfluorous
nonenoxybenzenesulfonate
(OBS)
0.32,
0.19,
0.10
ng/g
dry
weight
(dw),
respectively.
The
detection
frequencies
(DFs)
Cl-PFESAs
OBS
both
greater
than
96%,
followed
by
trimer
acid
(HFPO-TrA,
DF:
85%).
Notably,
level
HFPO-TrA
one
sample
was
as
high
540
dw,
indicating
a
potential
environmental
risk
to
humans.
addition,
significantly
higher
that
(p
<
0.05).
However,
no
significant
differences
observed
materials
origins.
This
suggests
PFASs,
particularly
are
widely
detected
products
across
is
source
landfill
contamination
human
exposure.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(16), С. 6890 - 6899
Опубликована: Апрель 12, 2024
Halogenated
organic
compounds
(HOCs)
are
a
class
of
contaminants
showing
high
toxicity,
low
biodegradability,
and
bioaccumulation
potential,
especially
chlorinated
brominated
HOCs
(Cl/Br-HOCs).
Knowledge
gaps
exist
on
whether
novel
Cl/Br-HOCs
could
penetrate
the
placental
barrier
cause
adverse
birth
outcomes.
Herein,
326
cord
blood
samples
were
collected
in
hospital
Jinan,
Shandong
Province
from
February
2017
to
January
2022,
44
identified
with
communicating
confidence
level
above
4
based
nontarget
approach,
covering
veterinary
drugs,
pesticides,
their
transformation
products,
pharmaceutical
personal
care
disinfection
byproducts,
so
on.
To
our
knowledge,
presence
closantel,
bromoxynil,
4-hydroxy-2,5,6-trichloroisophthalonitrile,
2,6-dibromo-4-nitrophenol,
related
components
was
reported
for
first
time.
Both
multiple
linear
regression
(MLR)
Bayesian
kernel
machine
(BKMR)
models
applied
evaluate
relationships
newborn
outcomes
(birth
weight,
length,
ponderal
index)
individual
Cl/Br-HOC
mixture
exposure,
respectively.
A
significantly
negative
association
observed
between
pentachlorophenol
exposure
but
significance
vanished
after
false
discovery
rate
correction.
The
BKMR
analysis
showed
that
associated
reduced
indicating
higher
risks
fetal
growth
restriction.
Our
findings
offer
an
overview
exposome
during
early
life
stage
enhance
understanding
its
risks.
Eco-Environment & Health,
Год журнала:
2024,
Номер
3(4), С. 476 - 493
Опубликована: Авг. 30, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
endocrine
disruptors
with
unambiguous
neurotoxic
effects.
However,
due
to
variability
in
experimental
models,
population
characteristics,
molecular
endpoints,
the
elucidation
of
mechanisms
underlying
PFAS-induced
neurotoxicity
remains
incomplete.
In
this
review,
we
utilized
adverse
outcome
pathway
(AOP)
framework,
a
comprehensive
tool
for
evaluating
toxicity
across
multiple
biological
levels
(molecular,
cellular,
tissue
organ,
individual,
population),
elucidate
induced
by
PFAS.
Based
on
271
studies,
reactive
oxygen
species
(ROS)
generation
emerged
as
initiating
event
1
(MIE1).
Subsequent
key
events
(KEs)
at
cellular
level
include
oxidative
stress,
neuroinflammation,
apoptosis,
altered
Ca
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(42), С. 18928 - 18939
Опубликована: Окт. 12, 2024
Chlorinated
polyfluorinated
ether
sulfonic
acid
(F-53B),
a
commonly
utilized
alternative
for
perfluorooctane
sulfonate,
was
detected
in
pregnant
women
and
cord
blood
recently.
However,
the
lack
of
detailed
toxicokinetic
information
poses
significant
challenge
assessing
human
risk
assessment
F-53B
exposure.
Our
study
aimed
to
develop
physiologically
based
pharmacokinetic
(PBPK)
model
mice,
on
experiments,
extrapolating
it
humans.
Pregnant
mice
were
administered
80
μg/kg
orally
intravenously
gestational
day
13.
concentrations
biological
samples
analyzed
via
ultraperformance
liquid
chromatography-mass
spectrometry.
Results
showed
highest
accumulation
brain,
followed
by
placenta,
amniotic
fluid,
liver
fetal
mice.
These
data
applied
PBPK
development
evaluation,
Monte
Carlo
simulations
used
characterize
variability
uncertainty
population.
Most
predictive
values
within
2-fold
range
experimental
(>72%)
had
coefficient
determination
(R
Molecules,
Год журнала:
2025,
Номер
30(11), С. 2313 - 2313
Опубликована: Май 25, 2025
As
regulations
ban
legacy
PFASs,
many
emerging
PFASs
are
being
developed,
leading
to
their
release
into
the
aquatic
environment
and
drinking
water.
However,
research
studies
on
these
in
water
limited,
current
standards
only
cover
a
few
leaving
unregulated
toxicity
unknown.
Therefore,
machine
learning-based
suspect
screening
combined
with
target
was
employed
comprehensively
identify
quantify
both
novel
from
Yangtze
River
Delta,
potential
sources
of
contamination
were
determined
through
pollutant
profile
analysis.
A
total
30
identified,
including
16
14
categorized
11
classes.
Quantitative
semi-quantitative
analyses
revealed
that
maximum
concentrations
ranged
<LOQ
(limit
quantification)
48.92
ng/L.
Notably,
PFPeA
(48.92
ng/L),
perfluorobutanoic
acid
(PFBA,
44.83
perfluorooctanoic
(PFOA,
37.72
perfluorobutanesulfonic
(PFBS,
26.77
bis(trifluoromethanesulfonyl)imide
(HNTf2,
15.02
ng/L)
exhibited
higher
compared
other
PFASs.
The
analysis
suggested
Delta’s
more
likely
originate
pollution
upper
middle
reaches
rather
than
local
industrial
emissions.
Then,
identified
prioritized
by
integrating
PBT
(persistence,
bioaccumulation,
toxicity)
properties
environmental
exposure
data.
In
prioritization
risk
assessment
process,
ten
high-concern
had
Risk
Indexes
(RIs)
those
ref-PFOA
ref-PFOS,
eight
two
Delta
originates
surface
lower
River,
which
accumulates
pollutants
its
reaches,
affecting
health
over
20
million
people.
Our
findings
indicated
presence
region’s
demonstrated
conceptual
models
for
chemical
information
prediction
assessment.
Although
levels
relatively
low,
still
dominate.
Further
is
needed
identify,
monitor,
assess
risks
