Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

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Exploring Prenatal Exposure to Halogenated Compounds and Its Relationship with Birth Outcomes Using Nontarget Analysis

Environmental Science & Technology, Год журнала: 2024, Номер 58(16), С. 6890 - 6899

Опубликована: Апрель 12, 2024

Halogenated organic compounds (HOCs) are a class of contaminants showing high toxicity, low biodegradability, and bioaccumulation potential, especially chlorinated brominated HOCs (Cl/Br-HOCs). Knowledge gaps exist on whether novel Cl/Br-HOCs could penetrate the placental barrier cause adverse birth outcomes. Herein, 326 cord blood samples were collected in hospital Jinan, Shandong Province from February 2017 to January 2022, 44 identified with communicating confidence level above 4 based nontarget approach, covering veterinary drugs, pesticides, their transformation products, pharmaceutical personal care disinfection byproducts, so on. To our knowledge, presence closantel, bromoxynil, 4-hydroxy-2,5,6-trichloroisophthalonitrile, 2,6-dibromo-4-nitrophenol, related components was reported for first time. Both multiple linear regression (MLR) Bayesian kernel machine (BKMR) models applied evaluate relationships newborn outcomes (birth weight, length, ponderal index) individual Cl/Br-HOC mixture exposure, respectively. A significantly negative association observed between pentachlorophenol exposure but significance vanished after false discovery rate correction. The BKMR analysis showed that associated reduced indicating higher risks fetal growth restriction. Our findings offer an overview exposome during early life stage enhance understanding its risks.

Язык: Английский

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Occurrence of rare earth elements in umbilical cord serum and association with thyroid hormones and birth outcomes in newborns

Chemosphere, Год журнала: 2024, Номер 359, С. 142321 - 142321

Опубликована: Май 14, 2024

Язык: Английский

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Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review

Eco-Environment & Health, Год журнала: 2024, Номер 3(4), С. 476 - 493

Опубликована: Авг. 30, 2024

Per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with unambiguous neurotoxic effects. However, due to variability in experimental models, population characteristics, molecular endpoints, the elucidation of mechanisms underlying PFAS-induced neurotoxicity remains incomplete. In this review, we utilized adverse outcome pathway (AOP) framework, a comprehensive tool for evaluating toxicity across multiple biological levels (molecular, cellular, tissue organ, individual, population), elucidate induced by PFAS. Based on 271 studies, reactive oxygen species (ROS) generation emerged as initiating event 1 (MIE1). Subsequent key events (KEs) at cellular level include oxidative stress, neuroinflammation, apoptosis, altered Ca

Язык: Английский

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Accumulation features and temporal trends (2002–2015) for legacy and emerging per- and polyfluoroalkyl substances (PFASs) in finless porpoises bycaught off Korean coasts

Environmental Pollution, Год журнала: 2024, Номер 349, С. 123925 - 123925

Опубликована: Апрель 7, 2024

Язык: Английский

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Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)

Toxics, Год журнала: 2024, Номер 12(7), С. 501 - 501

Опубликована: Июль 10, 2024

Per- and polyfluoroalkyl substances (PFAS) are found in many consumer industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) perfluorooctanesulfonic (PFOS), developmentally toxic mammals, the vast majority of PFAS have not been evaluated for developmental toxicity potential. A concentration-response study 182 unique chemicals using zebrafish medium-throughput, vertebrate assay was conducted to investigate chemical structural identifiers toxicity. Embryos were exposed each compound (≤100 μM) beginning on day fertilization. At 6 days post-fertilization (dpf), two independent observers graded landmarks larva (e.g., mortality, hatching, swim bladder inflation, edema, abnormal spine/tail, or craniofacial structure). Thirty percent toxic, but there no enrichment any OECD category. PFOS (benchmark concentration [BMC] = 7.48 μM); however, other more potent: perfluorooctanesulfonamide (PFOSA), N-methylperfluorooctane sulfonamide (N-MeFOSA), ((perfluorooctyl)ethyl)phosphonic acid, perfluoro-3,6,9-trioxatridecanoic perfluorohexane sulfonamide. The profile these potent is largely unexplored mammals species. Based results, additional screening may be warranted understand

Язык: Английский

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Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans

Environmental Science & Technology, Год журнала: 2024, Номер 58(42), С. 18928 - 18939

Опубликована: Окт. 12, 2024

Chlorinated polyfluorinated ether sulfonic acid (F-53B), a commonly utilized alternative for perfluorooctane sulfonate, was detected in pregnant women and cord blood recently. However, the lack of detailed toxicokinetic information poses significant challenge assessing human risk assessment F-53B exposure. Our study aimed to develop physiologically based pharmacokinetic (PBPK) model mice, on experiments, extrapolating it humans. Pregnant mice were administered 80 μg/kg orally intravenously gestational day 13. concentrations biological samples analyzed via ultraperformance liquid chromatography-mass spectrometry. Results showed highest accumulation brain, followed by placenta, amniotic fluid, liver fetal mice. These data applied PBPK development evaluation, Monte Carlo simulations used characterize variability uncertainty population. Most predictive values within 2-fold range experimental (>72%) had coefficient determination (R

Язык: Английский

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Effects of early-life F-53B exposure on thyroid function in juvenile rats: the role of the cAMP signaling pathway

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137751 - 137751

Опубликована: Фев. 1, 2025

Язык: Английский

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Bayesian Benchmark Dose Assessment of Per- and Polyfluorinated Substances Exposure-Associated Thyroid Function Disruption During Pregnancy

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115456 - 115456

Опубликована: Апрель 1, 2025

Язык: Английский

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Occurrence, Sources, and Prioritization of Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water from Yangtze River Delta, China: Focusing on Emerging PFASs

Molecules, Год журнала: 2025, Номер 30(11), С. 2313 - 2313

Опубликована: Май 25, 2025

As regulations ban legacy PFASs, many emerging PFASs are being developed, leading to their release into the aquatic environment and drinking water. However, research studies on these in water limited, current standards only cover a few leaving unregulated toxicity unknown. Therefore, machine learning-based suspect screening combined with target was employed comprehensively identify quantify both novel from Yangtze River Delta, potential sources of contamination were determined through pollutant profile analysis. A total 30 identified, including 16 14 categorized 11 classes. Quantitative semi-quantitative analyses revealed that maximum concentrations ranged <LOQ (limit quantification) 48.92 ng/L. Notably, PFPeA (48.92 ng/L), perfluorobutanoic acid (PFBA, 44.83 perfluorooctanoic (PFOA, 37.72 perfluorobutanesulfonic (PFBS, 26.77 bis(trifluoromethanesulfonyl)imide (HNTf2, 15.02 ng/L) exhibited higher compared other PFASs. The analysis suggested Delta’s more likely originate pollution upper middle reaches rather than local industrial emissions. Then, identified prioritized by integrating PBT (persistence, bioaccumulation, toxicity) properties environmental exposure data. In prioritization risk assessment process, ten high-concern had Risk Indexes (RIs) those ref-PFOA ref-PFOS, eight two Delta originates surface lower River, which accumulates pollutants its reaches, affecting health over 20 million people. Our findings indicated presence region’s demonstrated conceptual models for chemical information prediction assessment. Although levels relatively low, still dominate. Further is needed identify, monitor, assess risks

Язык: Английский

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