Legacy and emerging per- and polyfluoroalkyl substances in tissue and toilet paper from China DOI Creative Commons
Nannan Wan,

Yu Liu,

Xinghui Zhang

и другие.

Journal of Hazardous Materials Letters, Год журнала: 2024, Номер 5, С. 100109 - 100109

Опубликована: Апрель 3, 2024

Per- and polyfluoroalkyl substances (PFASs) have been found in toilet paper Europe, the United States, Africa; however, their presence Chinese household has not investigated. In this study, 21 legacy 30 emerging PFASs were analyzed tissue from China, including 48 samples of different origins materials. Median concentrations chlorinated polyfluorinated ether sulfonates (Cl-PFESAs), hexafluoropropylene oxide homologs (HFPOs), p-perfluorous nonenoxybenzenesulfonate (OBS) 0.32, 0.19, 0.10 ng/g dry weight (dw), respectively. The detection frequencies (DFs) Cl-PFESAs OBS both greater than 96%, followed by trimer acid (HFPO-TrA, DF: 85%). Notably, level HFPO-TrA one sample was as high 540 dw, indicating a potential environmental risk to humans. addition, significantly higher that (p < 0.05). However, no significant differences observed materials origins. This suggests PFASs, particularly are widely detected products across is source landfill contamination human exposure.

Язык: Английский

Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts DOI

Lucas Gaillard,

Robert Barouki,

Étienne Blanc

и другие.

Trends in Endocrinology and Metabolism, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

Процитировано

12

Exploring Prenatal Exposure to Halogenated Compounds and Its Relationship with Birth Outcomes Using Nontarget Analysis DOI

Huan Lin,

Wei Gao, Jingjing Li

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(16), С. 6890 - 6899

Опубликована: Апрель 12, 2024

Halogenated organic compounds (HOCs) are a class of contaminants showing high toxicity, low biodegradability, and bioaccumulation potential, especially chlorinated brominated HOCs (Cl/Br-HOCs). Knowledge gaps exist on whether novel Cl/Br-HOCs could penetrate the placental barrier cause adverse birth outcomes. Herein, 326 cord blood samples were collected in hospital Jinan, Shandong Province from February 2017 to January 2022, 44 identified with communicating confidence level above 4 based nontarget approach, covering veterinary drugs, pesticides, their transformation products, pharmaceutical personal care disinfection byproducts, so on. To our knowledge, presence closantel, bromoxynil, 4-hydroxy-2,5,6-trichloroisophthalonitrile, 2,6-dibromo-4-nitrophenol, related components was reported for first time. Both multiple linear regression (MLR) Bayesian kernel machine (BKMR) models applied evaluate relationships newborn outcomes (birth weight, length, ponderal index) individual Cl/Br-HOC mixture exposure, respectively. A significantly negative association observed between pentachlorophenol exposure but significance vanished after false discovery rate correction. The BKMR analysis showed that associated reduced indicating higher risks fetal growth restriction. Our findings offer an overview exposome during early life stage enhance understanding its risks.

Язык: Английский

Процитировано

8

Occurrence of rare earth elements in umbilical cord serum and association with thyroid hormones and birth outcomes in newborns DOI
Xin Liu, Qian Xiang, Lei Zhang

и другие.

Chemosphere, Год журнала: 2024, Номер 359, С. 142321 - 142321

Опубликована: Май 14, 2024

Язык: Английский

Процитировано

5

Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review DOI Creative Commons
Shen-Pan Li,

Shuang-Jian Qin,

Huixian Zeng

и другие.

Eco-Environment & Health, Год журнала: 2024, Номер 3(4), С. 476 - 493

Опубликована: Авг. 30, 2024

Per- and polyfluoroalkyl substances (PFAS) are endocrine disruptors with unambiguous neurotoxic effects. However, due to variability in experimental models, population characteristics, molecular endpoints, the elucidation of mechanisms underlying PFAS-induced neurotoxicity remains incomplete. In this review, we utilized adverse outcome pathway (AOP) framework, a comprehensive tool for evaluating toxicity across multiple biological levels (molecular, cellular, tissue organ, individual, population), elucidate induced by PFAS. Based on 271 studies, reactive oxygen species (ROS) generation emerged as initiating event 1 (MIE1). Subsequent key events (KEs) at cellular level include oxidative stress, neuroinflammation, apoptosis, altered Ca

Язык: Английский

Процитировано

5

Development of a Physiologically Based Pharmacokinetic (PBPK) Model for F-53B in Pregnant Mice and Its Extrapolation to Humans DOI Creative Commons
Jing Zhang, Shen-Pan Li, Qingqing Li

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(42), С. 18928 - 18939

Опубликована: Окт. 12, 2024

Chlorinated polyfluorinated ether sulfonic acid (F-53B), a commonly utilized alternative for perfluorooctane sulfonate, was detected in pregnant women and cord blood recently. However, the lack of detailed toxicokinetic information poses significant challenge assessing human risk assessment F-53B exposure. Our study aimed to develop physiologically based pharmacokinetic (PBPK) model mice, on experiments, extrapolating it humans. Pregnant mice were administered 80 μg/kg orally intravenously gestational day 13. concentrations biological samples analyzed via ultraperformance liquid chromatography-mass spectrometry. Results showed highest accumulation brain, followed by placenta, amniotic fluid, liver fetal mice. These data applied PBPK development evaluation, Monte Carlo simulations used characterize variability uncertainty population. Most predictive values within 2-fold range experimental (>72%) had coefficient determination (R

Язык: Английский

Процитировано

5

Accumulation features and temporal trends (2002–2015) for legacy and emerging per- and polyfluoroalkyl substances (PFASs) in finless porpoises bycaught off Korean coasts DOI
Yunsun Jeong,

Sori Mok,

Kyum Joon Park

и другие.

Environmental Pollution, Год журнала: 2024, Номер 349, С. 123925 - 123925

Опубликована: Апрель 7, 2024

Язык: Английский

Процитировано

4

Effects of early-life F-53B exposure on thyroid function in juvenile rats: the role of the cAMP signaling pathway DOI
Shen-Pan Li, Zhao Wen-hui,

Jing Zhang

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 137751 - 137751

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Bayesian Benchmark Dose Assessment of Per- and Polyfluorinated Substances Exposure-Associated Thyroid Function Disruption During Pregnancy DOI
Shiwen Li,

Jingguang Li,

Yongning Wu

и другие.

Food and Chemical Toxicology, Год журнала: 2025, Номер unknown, С. 115456 - 115456

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Occurrence, Sources, and Prioritization of Per- and Polyfluoroalkyl Substances (PFASs) in Drinking Water from Yangtze River Delta, China: Focusing on Emerging PFASs DOI Creative Commons

Zixin Qian,

Chao Feng, Yuhang Chen

и другие.

Molecules, Год журнала: 2025, Номер 30(11), С. 2313 - 2313

Опубликована: Май 25, 2025

As regulations ban legacy PFASs, many emerging PFASs are being developed, leading to their release into the aquatic environment and drinking water. However, research studies on these in water limited, current standards only cover a few leaving unregulated toxicity unknown. Therefore, machine learning-based suspect screening combined with target was employed comprehensively identify quantify both novel from Yangtze River Delta, potential sources of contamination were determined through pollutant profile analysis. A total 30 identified, including 16 14 categorized 11 classes. Quantitative semi-quantitative analyses revealed that maximum concentrations ranged <LOQ (limit quantification) 48.92 ng/L. Notably, PFPeA (48.92 ng/L), perfluorobutanoic acid (PFBA, 44.83 perfluorooctanoic (PFOA, 37.72 perfluorobutanesulfonic (PFBS, 26.77 bis(trifluoromethanesulfonyl)imide (HNTf2, 15.02 ng/L) exhibited higher compared other PFASs. The analysis suggested Delta’s more likely originate pollution upper middle reaches rather than local industrial emissions. Then, identified prioritized by integrating PBT (persistence, bioaccumulation, toxicity) properties environmental exposure data. In prioritization risk assessment process, ten high-concern had Risk Indexes (RIs) those ref-PFOA ref-PFOS, eight two Delta originates surface lower River, which accumulates pollutants its reaches, affecting health over 20 million people. Our findings indicated presence region’s demonstrated conceptual models for chemical information prediction assessment. Although levels relatively low, still dominate. Further is needed identify, monitor, assess risks

Язык: Английский

Процитировано

0

Toxicokinetics, tissue distribution, and toxic potency of PFOS alternative OBS in adult zebrafish (Danio rerio) based on flow-through exposure system DOI
Yilong Zou, Yu Zhou, Xianglian Wang

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 300, С. 118445 - 118445

Опубликована: Июнь 4, 2025

Язык: Английский

Процитировано

0