Transformation products of antibiotics: overlooked drivers for enhancing the environmental spread of antibiotic resistance DOI Open Access

Yuan Zhang,

Jiayan Jiang, Mingbao Feng

и другие.

Journal of Environmental Exposure Assessment, Год журнала: 2025, Номер 4(2)

Опубликована: Апрель 10, 2025

Humans have released thousands of antibiotics into the environment, which is a primary driver global dissemination bacterial resistance. Parent compounds can generate various transformation products (TPs), many remain unidentified and lack comprehensive microbial risk assessments. The TPs formed during process may exhibit structural similarities to parent compounds, they induce antibiotic-like resistance transmission despite lacking bactericidal/antibacterial properties compounds. However, assessments antimicrobial hazards predominantly emphasize while largely neglecting their TPs. Here, we highlight that warrant greater attention regarding chemical structure identification transmission. This perspective summarizes TPs’ potential, mechanisms, challenges in triggering

Язык: Английский

Profiles, drivers, and prioritization of antibiotics in China’s major rivers DOI
Yi Liu, Meng Zhang, Wu Yang

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 477, С. 135399 - 135399

Опубликована: Авг. 2, 2024

Язык: Английский

Процитировано

20

Discovering Novel Organophosphorus Compounds in Wastewater Treatment Plant Effluents through Suspect Screening and Nontarget Analysis DOI
Jingrun Hu,

Yitao Lyu,

Mingzhen Li

и другие.

Environmental Science & Technology, Год журнала: 2024, Номер 58(14), С. 6402 - 6414

Опубликована: Март 28, 2024

Limited knowledge on the structure of emerging organophosphorus compounds (OPCs) hampers our comprehensive understanding their environmental occurrence and potential risks. Through suspect nontarget screening, combining data-dependent acquisition, data-independent parallel reaction monitoring modes, we identified 60 OPCs (17 traditional 43 compounds) in effluents 14 wastewater treatment plants (WWTPs) Beijing Qinghai, China. These comprise 26 organophosphate triesters, 17 diesters, 6 organophosphonates, 7 organothiophosphate esters, 4 other OPCs. Notably, were newly WWTP effluents, 16 discovered matrices. Specifically, cyclic phosphonate, (5-ethyl-2-methyl-1,3,2-dioxaphosphorinan-5-yl)methyl dimethyl phosphonate P-oxide (PMMMPn), consistently appeared all with semiquantitative concentrations ranging from 44.4 to 282 ng/L. Its analogue, di-PMMMPn, presented 93% samples. Compositional differences between two cities mainly attributed Hazard ecological risk assessment underscored substantial contribution chlorinated esters overall risks effluents. This study provides most OPC profiles date, highlighting need for further research occurrence, fate, risks, particularly

Язык: Английский

Процитировано

18

Water Analysis: Emerging Contaminants and Current Issues DOI
Susan D. Richardson, Tarek Manasfi

Analytical Chemistry, Год журнала: 2024, Номер 96(20), С. 8184 - 8219

Опубликована: Май 3, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWater Analysis: Emerging Contaminants and Current IssuesSusan D. Richardson*Susan RichardsonDepartment of Chemistry Biochemistry, University South Carolina, JM Palms Center for GSR, 631 Sumter Street, Columbia, Carolina 29208, United States*[email protected]More by Susan RichardsonView Biographyhttps://orcid.org/0000-0001-6207-4513 Tarek ManasfiTarek ManasfiEawag, Environmental Chemistry, Uberlandstrasse 133, Dubendorf 8600, SwitzerlandMore ManasfiView BiographyCite this: Anal. Chem. 2024, 96, 20, 8184–8219Publication Date (Web):May 3, 2024Publication History Received16 March 2024Accepted16 April 2024Revised14 2024Published online3 May inissue 21 2024https://pubs.acs.org/doi/10.1021/acs.analchem.4c01423https://doi.org/10.1021/acs.analchem.4c01423review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views826Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Drinking water,Extraction,Impurities,Liquid chromatography,Mass spectrometry Get e-Alerts

Язык: Английский

Процитировано

18

Pore modulation of single atomic Fe sites for ultrafast Fenton-like chemistry with amplified electron migration oxidation DOI

Kexin Yin,

Xing Xu, Qinyan Yue

и другие.

Water Research, Год журнала: 2024, Номер 268, С. 122545 - 122545

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

15

Solid-liquid redistribution and degradation of antibiotics during hydrothermal treatment of sewage sludge: Interaction between biopolymers and antibiotics DOI

Siying Cai,

Xinyu Zhang,

Shuaiyu Chen

и другие.

Water Research, Год журнала: 2024, Номер 258, С. 121759 - 121759

Опубликована: Май 9, 2024

Язык: Английский

Процитировано

10

Accumulation of antibiotics in the environment: Have appropriate measures been taken to protect Canadian human and ecological health? DOI Creative Commons

Oluwatosin Joseph Aladekoyi,

Salsabil Siddiqui,

Patricia Hania

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 280, С. 116513 - 116513

Опубликована: Май 31, 2024

In Canada, every day, contaminants of emerging concern (CEC) are discharged from waste treatment facilities into freshwaters. CECs such as pharmaceutical active compounds (PhACs), personal care products (PCPs), per- and polyfluoroalkyl substances (PFAS), microplastics legally sewage plants (STPs), water reclamation (WRPs), hospital wastewater (HWWTPs), or other forms (WWTFs). 2006, the Government Canada established Chemicals Management Plan (CMP) to classify chemicals based on a risk-priority assessment, which ranked many PhACs being low urgency, therefore permitting these continue released environment at unmonitored rates. The problem with ranking priority is that CMP's risk management assessment overlooks long-term environmental synergistic effects PhAC accumulation, antibiotic CEC accumulation in spread resistance genes. goal this review specifically investigate associated risks human health, well determine whether appropriate legislative strategies place within Canada's governance framework. research, secondary data levels Canadian international wastewaters, their potential promote antibiotic-resistant residues, short- risks, were all considered. Unlike similar past reviews, employed an interdisciplinary approach propose new perspectives science, engineering, law.

Язык: Английский

Процитировано

9

Incorporating Transformation Products for an Integrated Assessment of Antibiotic Pollution and Risks in Surface Water DOI
Jingrun Hu,

Yitao Lyu,

Yi Liu

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер 59(5), С. 2815 - 2826

Опубликована: Янв. 30, 2025

The widespread presence of antibiotics in aquatic ecosystems is a global challenge, yet the occurrence and risks associated with their transformation products (TPs) remain poorly understood. This study investigated potential TPs water along Chaobai River Beijing. We used high-resolution mass spectrometry an integrated target, suspect, nontarget screening approach to identify 21 parent 78 among 90 samples, majority from macrolides sulfonamides. Notably, target quantification machine-learning-assisted semiquantification revealed that cumulative concentrations were higher than compounds, average contributions ranging between 50.7 63.7%. Most downstream samples largely influenced by domestic sewage, as indicated significantly proportions TPs, well greater diversity composition profiles compared upstream reservoir samples. Moreover, 26.9, 67.9, 6.4% exhibited persistence, mobility, or toxicity antibiotics, respectively. Sixteen macrolide presented both ecological organisms resistance selection antibiotics. contributed substantially overall antibiotic-related 31.2 54.1%. highlights antibiotic river water, underscoring need consider comprehensive risk assessments

Язык: Английский

Процитировано

1

Antibiotics in the global river system arising from human consumption DOI Creative Commons
Heloisa Ehalt Macedo, Bernhard Lehner, Jim A. Nicell

и другие.

PNAS Nexus, Год журнала: 2025, Номер 4(4)

Опубликована: Март 27, 2025

Abstract The presence of antibiotics in surface waters poses risks to aquatic ecosystems and human health due their toxicity influence on antimicrobial resistance. After consumption partial metabolism, antibiotic residues are excreted undergo complex accumulation decay processes along pathway from wastewater natural river systems. Here, we use a global contaminant fate model estimate that the annual 40 most used (29,200 tonnes), 8,500 tonnes (29%) released into system 3,300 (11%) reach world's oceans or inland sinks. Even when only domestic sources considered (i.e. not including veterinary industrial sources), 6 million km rivers worldwide subject total concentrations excess thresholds protective resistance promotion during low streamflow conditions, with dominant contributors being amoxicillin, ceftriaxone, cefixime. Therefore, it is concern alone represents significant risk for across all continents, largest extents found Southeast Asia. Global has grown rapidly over last 15 years continues increase, particularly low- middle-income countries, requiring new strategies safeguard water quality protect ecosystem health.

Язык: Английский

Процитировано

1

Tracing Contaminants of Emerging Concern and Their Transformations in the Whole Treatment Process of a Municipal Wastewater Treatment Plant Using Nontarget Screening and Molecular Networking Strategies DOI
Zhenguo Chen,

Di Xia,

Huangrui Liu

и другие.

Water Research, Год журнала: 2024, Номер 267, С. 122522 - 122522

Опубликована: Сен. 25, 2024

Язык: Английский

Процитировано

6

Vital role of CYP450 in the biodegradation of antidiabetic drugs in the aerobic activated sludge system and the mechanisms DOI

Ligui Wu,

Hao Luo,

Jingcheng Xu

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 469, С. 134056 - 134056

Опубликована: Март 15, 2024

Язык: Английский

Процитировано

4