PNAS Nexus,
Journal Year:
2025,
Volume and Issue:
4(4)
Published: March 27, 2025
Abstract
The
presence
of
antibiotics
in
surface
waters
poses
risks
to
aquatic
ecosystems
and
human
health
due
their
toxicity
influence
on
antimicrobial
resistance.
After
consumption
partial
metabolism,
antibiotic
residues
are
excreted
undergo
complex
accumulation
decay
processes
along
pathway
from
wastewater
natural
river
systems.
Here,
we
use
a
global
contaminant
fate
model
estimate
that
the
annual
40
most
used
(29,200
tonnes),
8,500
tonnes
(29%)
released
into
system
3,300
(11%)
reach
world's
oceans
or
inland
sinks.
Even
when
only
domestic
sources
considered
(i.e.
not
including
veterinary
industrial
sources),
6
million
km
rivers
worldwide
subject
total
concentrations
excess
thresholds
protective
resistance
promotion
during
low
streamflow
conditions,
with
dominant
contributors
being
amoxicillin,
ceftriaxone,
cefixime.
Therefore,
it
is
concern
alone
represents
significant
risk
for
across
all
continents,
largest
extents
found
Southeast
Asia.
Global
has
grown
rapidly
over
last
15
years
continues
increase,
particularly
low-
middle-income
countries,
requiring
new
strategies
safeguard
water
quality
protect
ecosystem
health.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(14), P. 6402 - 6414
Published: March 28, 2024
Limited
knowledge
on
the
structure
of
emerging
organophosphorus
compounds
(OPCs)
hampers
our
comprehensive
understanding
their
environmental
occurrence
and
potential
risks.
Through
suspect
nontarget
screening,
combining
data-dependent
acquisition,
data-independent
parallel
reaction
monitoring
modes,
we
identified
60
OPCs
(17
traditional
43
compounds)
in
effluents
14
wastewater
treatment
plants
(WWTPs)
Beijing
Qinghai,
China.
These
comprise
26
organophosphate
triesters,
17
diesters,
6
organophosphonates,
7
organothiophosphate
esters,
4
other
OPCs.
Notably,
were
newly
WWTP
effluents,
16
discovered
matrices.
Specifically,
cyclic
phosphonate,
(5-ethyl-2-methyl-1,3,2-dioxaphosphorinan-5-yl)methyl
dimethyl
phosphonate
P-oxide
(PMMMPn),
consistently
appeared
all
with
semiquantitative
concentrations
ranging
from
44.4
to
282
ng/L.
Its
analogue,
di-PMMMPn,
presented
93%
samples.
Compositional
differences
between
two
cities
mainly
attributed
Hazard
ecological
risk
assessment
underscored
substantial
contribution
chlorinated
esters
overall
risks
effluents.
This
study
provides
most
OPC
profiles
date,
highlighting
need
for
further
research
occurrence,
fate,
risks,
particularly
Environmental Science & Technology,
Journal Year:
2025,
Volume and Issue:
59(5), P. 2815 - 2826
Published: Jan. 30, 2025
The
widespread
presence
of
antibiotics
in
aquatic
ecosystems
is
a
global
challenge,
yet
the
occurrence
and
risks
associated
with
their
transformation
products
(TPs)
remain
poorly
understood.
This
study
investigated
potential
TPs
water
along
Chaobai
River
Beijing.
We
used
high-resolution
mass
spectrometry
an
integrated
target,
suspect,
nontarget
screening
approach
to
identify
21
parent
78
among
90
samples,
majority
from
macrolides
sulfonamides.
Notably,
target
quantification
machine-learning-assisted
semiquantification
revealed
that
cumulative
concentrations
were
higher
than
compounds,
average
contributions
ranging
between
50.7
63.7%.
Most
downstream
samples
largely
influenced
by
domestic
sewage,
as
indicated
significantly
proportions
TPs,
well
greater
diversity
composition
profiles
compared
upstream
reservoir
samples.
Moreover,
26.9,
67.9,
6.4%
exhibited
persistence,
mobility,
or
toxicity
antibiotics,
respectively.
Sixteen
macrolide
presented
both
ecological
organisms
resistance
selection
antibiotics.
contributed
substantially
overall
antibiotic-related
31.2
54.1%.
highlights
antibiotic
river
water,
underscoring
need
consider
comprehensive
risk
assessments
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
280, P. 116513 - 116513
Published: May 31, 2024
In
Canada,
every
day,
contaminants
of
emerging
concern
(CEC)
are
discharged
from
waste
treatment
facilities
into
freshwaters.
CECs
such
as
pharmaceutical
active
compounds
(PhACs),
personal
care
products
(PCPs),
per-
and
polyfluoroalkyl
substances
(PFAS),
microplastics
legally
sewage
plants
(STPs),
water
reclamation
(WRPs),
hospital
wastewater
(HWWTPs),
or
other
forms
(WWTFs).
2006,
the
Government
Canada
established
Chemicals
Management
Plan
(CMP)
to
classify
chemicals
based
on
a
risk-priority
assessment,
which
ranked
many
PhACs
being
low
urgency,
therefore
permitting
these
continue
released
environment
at
unmonitored
rates.
The
problem
with
ranking
priority
is
that
CMP's
risk
management
assessment
overlooks
long-term
environmental
synergistic
effects
PhAC
accumulation,
antibiotic
CEC
accumulation
in
spread
resistance
genes.
goal
this
review
specifically
investigate
associated
risks
human
health,
well
determine
whether
appropriate
legislative
strategies
place
within
Canada's
governance
framework.
research,
secondary
data
levels
Canadian
international
wastewaters,
their
potential
promote
antibiotic-resistant
residues,
short-
risks,
were
all
considered.
Unlike
similar
past
reviews,
employed
an
interdisciplinary
approach
propose
new
perspectives
science,
engineering,
law.
