Environmental Science & Technology,
Год журнала:
2024,
Номер
58(20), С. 8643 - 8653
Опубликована: Апрель 27, 2024
Antimicrobial
nanomaterials
frequently
induce
inflammatory
reactions
within
lung
tissues
and
prompt
apoptosis
in
cells,
yielding
a
paradox
due
to
the
inherent
anti-inflammatory
character
of
apoptosis.
This
accentuates
elusive
nature
signaling
cascade
underlying
nanoparticle
(NP)-induced
pulmonary
inflammation.
In
this
study,
we
unveil
pivotal
role
nano-microflora
interactions,
serving
as
crucial
instigator
axis
NP-induced
Employing
microflora-deficient
mice,
provide
compelling
evidence
that
representative
antimicrobial
nanomaterial,
silver
(Ag)
NPs,
triggers
substantial
motility
impairment,
disrupts
quorum
sensing,
incites
DNA
leakage
from
microflora.
Subsequently,
liberated
molecules
recruit
caspase-1,
precipitating
release
proinflammatory
cytokines
activating
N-terminal
gasdermin
D
(GSDMD)
initiate
pyroptosis
macrophages.
pyroptotic
culminates
emergence
severe
Our
exploration
establishes
comprehensive
mechanistic
interlinks
activity
Ag
perturbations
microflora,
bacterial
release,
macrophage
pyroptosis,
consequent
inflammation,
which
helps
gain
an
in-depth
understanding
toxic
effects
triggered
by
environmental
NPs.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
176, С. 116777 - 116777
Опубликована: Май 24, 2024
Neuroimmune
and
neurodegenerative
ailments
impose
a
substantial
societal
burden.
disorders
involve
the
intricate
regulatory
interactions
between
immune
system
central
nervous
system.
Prominent
examples
of
neuroimmune
encompass
multiple
sclerosis
neuromyelitis
optica.
Neurodegenerative
diseases
result
from
neuronal
degeneration
or
demyelination
in
brain
spinal
cord,
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
amyotrophic
lateral
sclerosis.
The
precise
underlying
pathogenesis
these
conditions
remains
incompletely
understood.
Ferroptosis,
programmed
form
cell
death
characterised
by
lipid
peroxidation
iron
overload,
plays
pivotal
role
diseases.
In
this
review,
we
provide
detailed
overview
ferroptosis,
its
mechanisms,
pathways,
regulation
during
progression
Furthermore,
summarise
impact
ferroptosis
on
neuroimmune-related
cells
(T
cells,
B
neutrophils,
macrophages)
neural
(glial
neurons).
Finally,
explore
potential
therapeutic
implications
inhibitors
diverse
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 24, 2025
Abstract
Environmental
pollution
represents
a
significant
public
health
concern,
with
the
potential
risks
associated
environmental
pollutants
receiving
considerable
attention
over
an
extended
period.
In
recent
years,
substantial
body
of
research
has
been
dedicated
to
this
topic.
Since
discovery
ferroptosis,
iron-dependent
programmed
cell
death
typically
characterized
by
lipid
peroxidation,
in
2012,
there
have
advances
study
its
role
and
mechanism
various
diseases.
A
growing
number
studies
also
demonstrated
involvement
ferroptosis
damage
caused
organism
pollutants,
molecular
mechanisms
involved
partially
elucidated.
The
targeting
be
effective
means
ameliorating
PM2.5,
organic
inorganic
ionizing
radiation.
This
review
begins
providing
summary
most
important
ferroptosis.
It
then
proceeds
offer
critical
analysis
effects
induced
pollutants.
Furthermore,
as
is
case
all
rapidly
evolving
areas,
are
numerous
unanswered
questions
challenges
pertaining
pollutant-induced
which
we
discuss
attempt
provide
some
directions
clues
for
future
field.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 8, 2024
Ferroptosis,
distinct
from
apoptosis,
necrosis,
and
autophagy,
is
a
unique
type
of
cell
death
driven
by
iron-dependent
phospholipid
peroxidation.
Since
ferroptosis
was
defined
in
2012,
it
has
received
widespread
attention
researchers
worldwide.
From
biochemical
perspective,
the
regulation
strongly
associated
with
cellular
metabolism,
primarily
including
iron
lipid
redox
metabolism.
The
distinctive
regulatory
mechanism
holds
great
potential
for
overcoming
drug
resistance-a
major
challenge
treating
cancer.
considerable
role
nanobiotechnology
disease
treatment
been
widely
reported,
but
further
more
systematic
discussion
on
how
enhances
therapeutic
efficacy
ferroptosis-associated
diseases
still
needs
to
be
improved.
Moreover,
while
exciting
cancer
relatively
well
summarized,
its
applications
other
diseases,
such
as
neurodegenerative
cardiovascular
cerebrovascular
kidney
disease,
remain
underreported.
Consequently,
necessary
fill
these
gaps
complete
ferroptosis.
In
this
review,
we
provide
an
extensive
introduction
background
elaborate
network.
Subsequently,
discuss
various
advantages
combining
enhance
reduce
side
effects
diseases.
Finally,
analyze
feasibility
improving
clinical
outcomes
based
needs,
current
limitations
future
directions
ferroptosis,
which
will
not
only
significant
guidance
also
accelerate
their
translations.
