Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134356 - 134356

Published: April 19, 2024

Language: Английский

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A Systematic Review of Biomonitoring Microplastics in Environmental Matrices: Emphasis on Airborne Particles, Dry Deposits, and Comparative Analysis with Traditional Methods

Environmental Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100609 - 100609

Published: Jan. 1, 2025

Language: Английский

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Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137166 - 137166

Published: Jan. 9, 2025

Language: Английский

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Ferroptosis implication in environmental-induced neurotoxicity

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 934, P. 172618 - 172618

Published: April 24, 2024

Language: Английский

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Targeting ferroptosis in neuroimmune and neurodegenerative disorders for the development of novel therapeutics

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116777 - 116777

Published: May 24, 2024

Neuroimmune and neurodegenerative ailments impose a substantial societal burden. disorders involve the intricate regulatory interactions between immune system central nervous system. Prominent examples of neuroimmune encompass multiple sclerosis neuromyelitis optica. Neurodegenerative diseases result from neuronal degeneration or demyelination in brain spinal cord, such as Alzheimer's disease, Parkinson's Huntington's amyotrophic lateral sclerosis. The precise underlying pathogenesis these conditions remains incompletely understood. Ferroptosis, programmed form cell death characterised by lipid peroxidation iron overload, plays pivotal role diseases. In this review, we provide detailed overview ferroptosis, its mechanisms, pathways, regulation during progression Furthermore, summarise impact ferroptosis on neuroimmune-related cells (T cells, B neutrophils, macrophages) neural (glial neurons). Finally, explore potential therapeutic implications inhibitors diverse

Language: Английский

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Polybrominated biphenyls induce liver injury by disrupting the KEAP1/Nrf2/SLC7A11 axis leading to impaired GSH synthesis and ferroptosis in hepatocytes

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Language: Английский

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Ferroptosis induced by environmental pollutants and its health implications

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 24, 2025

Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.

Language: Английский

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Regulation of calcium signaling prevents neuronal death mediated by NIST DEP in xenoferroptotic cell death conditions

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137374 - 137374

Published: Jan. 1, 2025

Language: Английский

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Design of a Fractional-Order Environmental Toxin-Plankton System in Aquatic Ecosystems: A Novel Machine Predictive Expedition with Nonlinear Autoregressive Neuroarchitectures

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123640 - 123640

Published: April 1, 2025

Language: Английский

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Nanobiotechnology boosts ferroptosis: opportunities and challenges

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 8, 2024

Ferroptosis, distinct from apoptosis, necrosis, and autophagy, is a unique type of cell death driven by iron-dependent phospholipid peroxidation. Since ferroptosis was defined in 2012, it has received widespread attention researchers worldwide. From biochemical perspective, the regulation strongly associated with cellular metabolism, primarily including iron lipid redox metabolism. The distinctive regulatory mechanism holds great potential for overcoming drug resistance-a major challenge treating cancer. considerable role nanobiotechnology disease treatment been widely reported, but further more systematic discussion on how enhances therapeutic efficacy ferroptosis-associated diseases still needs to be improved. Moreover, while exciting cancer relatively well summarized, its applications other diseases, such as neurodegenerative cardiovascular cerebrovascular kidney disease, remain underreported. Consequently, necessary fill these gaps complete ferroptosis. In this review, we provide an extensive introduction background elaborate network. Subsequently, discuss various advantages combining enhance reduce side effects diseases. Finally, analyze feasibility improving clinical outcomes based needs, current limitations future directions ferroptosis, which will not only significant guidance also accelerate their translations.

Language: Английский

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