The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases
Cell Reports Medicine,
Год журнала:
2024,
Номер
5(6), С. 101581 - 101581
Опубликована: Май 22, 2024
Non-communicable
diseases
(NCD)
constitute
one
of
the
highest
burdens
disease
globally
and
are
associated
with
inflammatory
responses
in
target
organs.
There
is
increasing
evidence
significant
human
exposure
to
micro-
nanoplastics
(MnPs).
This
review
environmental
MnP
health
impacts
indicates
that
particles,
directly
indirectly
through
their
leachates,
may
exacerbate
inflammation.
Meanwhile,
persistent
inflammation
NCDs
gastrointestinal
respiratory
systems
potentially
increases
uptake,
thus
influencing
access
distal
Consequently,
a
future
increase
augments
risk
severity
NCDs.
critical
need
for
an
integrated
one-health
approach
research
assessing
drivers
bidirectional
links
Assessing
these
risks
requires
interdisciplinary
efforts
identify
link
organismal
uptake
studies
impacted
mechanisms
outcomes.
Язык: Английский
Amplification of benzo[a]pyrene toxicity persistence in earthworms by polystyrene nanoplastics: From organismal health to molecular responses
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
487, С. 137091 - 137091
Опубликована: Янв. 5, 2025
Язык: Английский
Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors
Environment International,
Год журнала:
2024,
Номер
194, С. 108883 - 108883
Опубликована: Июль 20, 2024
Particulate
matter
(PM)
has
always
received
widespread
attention,
PM2.5
pollution
is
associated
with
many
adverse
effects,
including
cardiovascular,
respiratory
and
metabolic
diseases
mood
disorders.
However,
the
underlying
mechanisms
are
not
yet
clear.
In
this
study,
small
animal
whole
body
inhalation
exposure
system
collected
real-time
in
real
environment,
which
can
truly
reflect
presence
status
of
atmospheric
environment.
This
study
investigated
depressive
like
behavior
mice
exposed
to
for
a
long
time
proved
its
molecular
mechanism
through
RNA-seq.
C57BL/6
male
were
ambient
air
together
control
mice,
who
breathed
filtered
high-efficiency
particulate
filters.
Depression
was
observed
PM
4,
6,
8
weeks
behavioral
experiments,
EEG
signals,
pathological
sections.
RNA-seq
results
indicated
that
might
be
related
pro-inflammatory
anti-inflammatory
cytokines,
as
well
BDNF
pathways
hippocampus
olfactory
bulb.
suggests
may
induce
depression
MAPK/CREB/BDNF
pathway.
Atmospheric
been
classified
Class
1
pollutant
by
International
Agency
Research
on
Cancer.
Current
research
mainly
believed
seriously
affected
lung
health,
but
there
little
effects
other
organs.
With
improvement
quality
life,
people
paying
more
attention
mental
while
brain.
simulated
environment
explored
brain
provided
solid
scientific
basis
inducing
after
exposure.
Язык: Английский
Toxicological effects and mechanisms of renal injury induced by inhalation exposure to airborne nanoplastics
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
488, С. 137393 - 137393
Опубликована: Янв. 30, 2025
Язык: Английский
Co-exposure to F-53B and Nanoplastics induced hepatic glucolipid metabolism disorders by the PI3K-AKT Signaling Pathway
Environmental Pollution,
Год журнала:
2025,
Номер
368, С. 125771 - 125771
Опубликована: Янв. 31, 2025
Язык: Английский
In vitro effects of aged low-density polyethylene micro(nano)plastic particles on human airway epithelial cells
Environmental Pollution,
Год журнала:
2025,
Номер
unknown, С. 126186 - 126186
Опубликована: Апрель 1, 2025
Язык: Английский
Distinct Effects between Polystyrene Micro- and Nanoplastics: Exacerbation of Adverse Outcomes in Inflammatory Bowel Disease-like Zebrafish and Mice
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Numerous
studies
have
demonstrated
that
micro-
and
nanoplastics
can
induce
adverse
effects
in
both
zebrafish
mice,
primarily
targeting
the
intestine
oral
exposure
scenarios.
Organisms
under
disease
conditions
are
suggested
to
exhibit
increased
susceptibility
environmental
pollutants,
with
inflammatory
bowel
(IBD)
serving
as
a
relevant
model
for
understanding
toxicity
initiated
diseased
intestine.
Here,
we
compared
outcomes
of
polystyrene
(PSMPs)
(PSNPs)
normal
IBD-like
mouse
models.
We
found
zebrafish,
no
significant
difference
mortality
was
elicited
by
two
particles,
while
fish
exhibited
greater
exposure.
Conversely,
transcriptomic
analysis
surviving
revealed
PSNPs
disrupted
metabolic
pathways,
particularly
galactose
metabolism,
induced
more
pronounced
apoptosis
intestinal
epithelial
cells
PSMPs
fish.
These
were
further
associated
an
increase
genus
Flavobacterium.
Similarly,
crypt
length
than
control
mice
severe
histological
injury
disruptions
gut
microbial
diversity
PSMPs,
mirroring
findings
zebrafish.
Notably,
shared
glycosphingolipid
synthesis
(globo
isoglobo
series)
NOD-like
receptor
signaling,
identified
response
PSNP
PSMP
models,
respectively,
along
consistent
decline
Firmicutes
abundance.
suggest
smaller-sized
may
pose
higher
health
risks
larger-sized
providing
key
insights
into
interactions
between
particles
compromised
biological
systems
their
resulting
outcomes.
Язык: Английский
Adipose Tissue Dysfunction Related to Climate Change and Air Pollution: Understanding the Metabolic Consequences
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7849 - 7849
Опубликована: Июль 18, 2024
Obesity,
a
global
pandemic,
poses
major
threat
to
healthcare
systems
worldwide.
Adipose
tissue,
the
energy-storing
organ
during
excessive
energy
intake,
functions
as
thermoregulator,
interacting
with
other
tissues
regulate
systemic
metabolism.
Specifically,
brown
adipose
tissue
(BAT)
is
positively
associated
an
increased
resistance
obesity,
due
its
thermogenic
function
in
presence
of
uncoupled
protein
1
(UCP1).
Recently,
studies
on
climate
change
and
influence
environmental
pollutants
homeostasis
obesity
have
drawn
increasing
attention.
The
reciprocal
relationship
between
adiposity
temperatures
results
reduced
adaptive
thermogenesis,
decreased
physical
activity,
carbon
footprint
production.
In
addition,
impact
makes
obese
individuals
more
prone
developing
type
2
diabetes
mellitus
(T2DM).
An
impaired
response
heat
stress,
compromised
vasodilation,
sweating
increase
risk
diabetes-related
comorbidities.
This
comprehensive
review
provides
information
about
effects
T2DM
development,
insights
into
causing
dysfunction
obesity.
altered
dietary
patterns
adaptation
strategies
mitigate
detrimental
are
also
discussed.
Язык: Английский
Airborne polystyrene nanoplastics exposure leads to heart failure via ECM-receptor interaction and PI3K/AKT/BCL-2 pathways
The Science of The Total Environment,
Год журнала:
2024,
Номер
954, С. 176469 - 176469
Опубликована: Сен. 23, 2024
Язык: Английский
Microplastic and nanoplastic exposure and risk of diabetes mellitus
World Journal of Clinical Cases,
Год журнала:
2024,
Номер
13(3)
Опубликована: Ноя. 8, 2024
The
issue
of
plastic
pollutants
has
become
a
growing
concern.
Both
microplastics
(MPs)
(particle
size
<
5
mm)
and
nanoplastics
(NPs)
1
µm)
can
cause
DNA
damage,
cytotoxicity,
oxidative
stress
in
various
organisms.
primary
known
impacts
microplastic/nanoplastic
are
observed
the
liver
respiratory
system,
leading
to
hepatotoxicity
chronic
obstructive
pulmonary
disease.
Although
research
on
effects
MPs
NPs
diabetes
is
still
its
early
stages,
there
potential
concerns.
This
editorial
highlights
risk
diabetics
from
co-exposure
contaminants
MPs/NPs,
supported
by
evidence
animal
studies
chemical
compositions
MPs/NPs.
Язык: Английский