THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Год журнала: 2024, Номер 28(3), С. 42 - 60

Опубликована: Дек. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Язык: Английский

The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective DOI Creative Commons
Andi Alijagić, Damir Suljević, Muhamed Fočak

и другие.

Environment International, Год журнала: 2024, Номер 188, С. 108736 - 108736

Опубликована: Май 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Язык: Английский

Процитировано

42
Systematic review of pulmonary toxicity induced by microplastics and nanoplastics: Insights from in vivo and in vitro studies DOI

Reza Nozari asl,

N. Jaafarzadeh, Faezeh Jahedi

и другие.

Annales de Toxicologie Analytique, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

6
Blood-brain barrier damage accelerates the accumulation of micro- and nanoplastics in the human central nervous system DOI
Jian Xie,

Jiale Ji,

Yun Sun

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136028 - 136028

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

12
A review on advancements in atmospheric microplastics research: The pivotal role of machine learning DOI

Jiaer Yang,

Zezhi Peng,

Jian Sun

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 945, С. 173966 - 173966

Опубликована: Июнь 17, 2024

Язык: Английский

Процитировано

10
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway DOI Creative Commons
Mingming Xu, Jiyuan Chen, Lin Gao

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 291, С. 117828 - 117828

Опубликована: Фев. 1, 2025

Microplastics pollution has raised a considerable awareness due to their extensive distribution in the environment. It potential side effects on human health. can enter respiratory system, then deposit lung, destroying structure of bronchus and alveoli, causing pulmonary inflammation, mucus production, airway hyperresponsiveness, leading aggravation asthma. Nevertheless, underlying mechanism remains elusive. There are several cytokines involved inflammatory response Heat shock protein 90α(HSP90α) is one involving inflammation which member HSPs family. The aim this study explore by microplastics influence secretion HSP90α progression Initially, we found that were destroyed epithelial barrier, resulting inherent dysfunction HSP90α. Then, proved activate PI3K-Akt-mTOR pathway prompting cells secrete proliferation smooth muscle cells(ASMCs), narrowing hypersensitivity. 1G6-D7 monoclonal antibody HSP90, reverse infiltration, hyperresponsiveness(AHR). Overall, these finding suggested elicited via signaling stimulated ASMCs. Hence, present unveils novel responsible for microplastic-induced hyperreactivity, establishing basis further research risk evaluations microplastics.

Язык: Английский

Процитировано

2
Aged fragmented-polypropylene microplastics induced ageing statues-dependent bioenergetic imbalance and reductive stress: In vivo and liver organoids-based in vitro study DOI Creative Commons
Wei Cheng,

Hange Chen,

Yue Zhou

и другие.

Environment International, Год журнала: 2024, Номер 191, С. 108949 - 108949

Опубликована: Авг. 15, 2024

Ageing is a nature process of microplastics that occurrs daily, and human beings are inevitably exposed to aged microplastics. However, systematic understanding ageing status its toxic effect currently still lacking. In this study, plastic cup lids-originated polypropylene (PP) were UV-photoaged until the carbonyl index (CI), canonical indicator for ageing, achieved 0.08, 0.17, 0.22 0.28. The adverse hepatic these PPs (aPPs) was evaluated in Balb/c mice (75 ng/mL water, about 200 particles/day) human-originated liver organoids (LOs, 50 particles/mL, ranged from 5.94 13.15 ng/mL) at low-dose equivalent exposure level. Low-dose PP could induce reductive stress both vitro vivo, by elevating NADH/NAD+ratio CI-dependent manner, together with hepatoxicity (indicated increased AST secretion cytotoxicity), disrupted genes encoding nutrients transporters NADH subunits accompanied restricted ATP supply, declined mitochondrial membrane potential complexI/IV activities, without significant increase MDA levels liver. These changes metabolism, representing circulatory panel increases lactate, triglyceride, Fgf21 levels, decreases pyruvate level, linked body weight gain but elevated contents following aPPs exposure. Additionally, assessing LOs, it found digestion drastically accelerated worsen energy supply upon mitochondria, "scattergun effect" induced formation micro- nano-plastics mixture toward NADH/NAD+imbalance.

Язык: Английский

Процитировано

9
Polystyrene Nanoplastics Hitch-Hike the Gut–Brain Axis to Exacerbate Parkinson’s Pathology DOI

Xiufang Liang,

Gangtong Huang, Yue Wang

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

The neurological implications of micro- and nanoplastic exposure have recently come under scrutiny due to the environmental prevalence these synthetic materials. Parkinson's disease (PD) is a major disorder clinically characterized by intracellular Lewy-body inclusions dopaminergic neuronal death. These pathological hallmarks PD, according Braak's hypothesis, are mediated afferent propagation α synuclein (αS) via enteric nervous system, or so-called gut-brain axis. Here we first examined effect polystyrene nanoplastics on peripheral central pathogenesis A53T, representative αS mutant. Specifically, accelerated amyloid aggregation A53T αS, which subsequently elevated in vitro production glial activation biomarkers, cytokines, reactive oxygen species compromised mitochondrial lysosomal membrane integrity, further shifting cellular metabolite profiles association with PD pathophysiology. In vivo, coadministration facilitated their synergistic gut-to-brain transmission mice, leading progressive impairment physical motor skills resemblance characteristic symptoms. This study provides insights into response vulnerability axis nanoplastics.

Язык: Английский

Процитировано

1
Inhalation of nanoplastics in the mouse model: Tissue bio-distribution and effects on the olfactory system DOI Creative Commons

G. M. Prosperi,

Natalia Marchetti,

Alessandro D’Elia

и другие.

The Science of The Total Environment, Год журнала: 2025, Номер 968, С. 178853 - 178853

Опубликована: Фев. 18, 2025

The impact of plastic fragments on human health is currently under investigation, with nanoplastics (NPs) being particularly concerning due to their small size. This allows them be inhaled, pass through blood barriers, and reach various organs. In this study, we evaluated the effects airborne NPs mouse olfactory system, which a primary target inhalation. Adult mice were exposed an aerosol solution containing synthetic polystyrene (PS-NPs) labelled red fluorophore for 5 h day over 7 days. Biodistribution analysis revealed that PS-NPs accumulated in tissues, such as brain, lung, adipose tissue, testicles, but cleared after one month. study first investigate inhaled bulb (OB) subventricular neurogenesis adult mice. We observed long-term impairments discrimination, decreased neuronal functionality, pro-inflammatory activation microglia OB following exposure. Surprisingly, noted compensatory increase neurogenesis, although insufficient counteract olfaction impairment induced by PS-NPs. These results provide novel insights into potential neurotoxic emphasize importance assessing occupational environmental exposure these pollutants.

Язык: Английский

Процитировано

1
Airborne micro- and nanoplastics: emerging causes of respiratory diseases DOI Creative Commons
Zixuan Gou, Haonan Wu, Shanyu Li

и другие.

Particle and Fibre Toxicology, Год журнала: 2024, Номер 21(1)

Опубликована: Дек. 4, 2024

Airborne micro- and nanoplastics (AMNPs) are ubiquitously present in human living environments pose significant threats to respiratory health. Currently, much research has been conducted on the relationship between (MNPs) cardiovascular gastrointestinal diseases, yet there is a clear lack of understanding regarding link AMNPs diseases. Therefore, it imperative explore two. Recent extensive studies by numerous scholars characteristics their with diseases have robustly demonstrated that from various sources significantly influence onset progression conditions. Thus, investigating intrinsic mechanisms involved finding necessary preventive therapeutic measures crucial. In this review, we primarily describe fundamental AMNPs, impact system, toxic facilitate disease development. It hoped article will provide new insights for further contribute advancement

Язык: Английский

Процитировано

4
Surfactant Additives in Water-Based Metalworking Fluids Lead to Strong Biophysical Inhibition of Pulmonary Surfactant Film DOI
Lulin Hu,

Weiyan Yu,

Yi Yang

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138358 - 138358

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0