Degradation of organophosphate flame retardants by white-rot fungi: Degradation pathways and associated toxicity

The Science of The Total Environment, Год журнала: 2025, Номер 959, С. 178260 - 178260

Опубликована: Янв. 1, 2025

The environmental persistence of organophosphate flame retardants (OPFRs) in water is becoming and concern. White Rot Fungi (WRF) have proven its capability to degrade certain OPFRs such as tributyl phosphate (TBP), tris(2-butoxyethyl) (TBEP), tris(2-chloroethyl) (TCEP) tris(2-chloroisopropyl) (TCPP). Despite this capability, there limited knowledge about the specific pathways involved degradation. In study, three different WRF were paired with individual OPFRs, potential transformation products (TPs) identified by UHPLC-HRMS. Some compounds structures further validated NMR. From these data degradation proposed. TBP was degraded successive hydroxylation hydrolysis reactions, a novel dehydrogenation step suggested. Both TCEP TCPP underwent oxidative dechlorination, experiencing subsequent hydrolysis. Uncommon reductive dehalogenation also observed. environmentally relevant methylation. TBEP generated numerous TPs, mainly dealkylations, along hydroxylation. Notably, demethylation proposed for first time. Additional secondary formed through oxidation initial metabolites. Finally, vivo silico toxicity assessments conducted, identifying TPs potentially toxic.

Язык: Английский

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Environmental Safety Perspectives on Organophosphate Flame Retardants: Current strategies and advancements in their environmental removal and detection

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 115340 - 115340

Опубликована: Янв. 1, 2025

Язык: Английский

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Adverse Effects of Aryl Organophosphate Esters on Reproduction

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Май 16, 2025

Aryl organophosphate esters (AOPEs) have been widely detected in environmental media and human samples, increasing evidence shows that AOPEs induce adverse effects on reproductive health. This Review summarizes the exposure levels, toxicity data, underlying mechanisms of three legacy AOPEs, including triphenyl phosphate (TPHP), 2-ethylhexyl diphenyl (EHDPP), tricresyl (TCrP). Reproduction-related nuclear receptors (RrNRs) were concluded to play important roles induced by as all typical their hydroxylated metabolites elicit binding affinity RrNRs. We further investigated RrNRs ability other 55 emerging (eAOPEs) through molecular docking found most eAOPEs (54/55) showed potential RrNRs, especially estrogen receptor α. helped us comprehensively understand reproduction predict health risk eAOPEs. are easily metabolized organisms, even show more potency bind RrRNs. also highlights necessity take contribution into account future research.

Язык: Английский

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Spatial variation, emissions, transport, and risk assessment of organophosphate esters in two large petrochemical complexes in southern China

Journal of Environmental Management, Год журнала: 2024, Номер 367, С. 122106 - 122106

Опубликована: Авг. 6, 2024

Язык: Английский

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