Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
73(9), С. 5092 - 5101
Опубликована: Фев. 24, 2025
This
study
investigates
the
combined
effects
of
polystyrene
nanoplastics
(PS-NPs)
and
deltamethrin
(DEL)
on
mice,
focusing
their
different
impacts
among
organs.
Mice
were
exposed
to
PS-NPs
and/or
DEL
for
30
days.
Results
showed
that
alleviated
DEL-induced
oxidative
damage
in
liver
kidney
by
reducing
its
accumulation
due
decreased
bioaccessibility.
Conversely,
increased
intestine,
leading
enhanced
susceptibility
enteric
infections
caused
bacteria,
viruses,
parasites,
as
indicated
transcriptomic
analysis.
delayed
excretion
gastrointestinal
motility,
evidenced
altered
neurotransmitter
levels,
thereby
contributing
greater
intestinal
DEL.
Moreover,
16S
rDNA
sequencing
revealed
tended
decrease
beneficial
bacteria
increase
pathogenic
gut
microbiota,
further
heightening
upon
coexposure.
The
findings
this
shed
new
light
complex
health
risks
associated
with
coexposure
pesticides.
Environmental Science & Technology Letters,
Год журнала:
2024,
Номер
11(12), С. 1262 - 1271
Опубликована: Ноя. 25, 2024
Microplastic
(MP)
pollution
has
become
a
global
issue,
attracting
attention
from
stakeholders
around
the
globe.
Knowledge
of
MPs
been
substantially
advanced
in
recent
years.
Newly
developed
analytical
technologies
allow
better
characterization
MPs,
but
characterizing
nanosized
plastic
particles
remains
challenging.
Transport
debris
land
to
oceans
is
key
driver
for
marine
pollution,
and
relative
contributions
riverine
runoff
atmospheric
deposition
must
be
further
quantified.
Another
lingering
issue
whether
can
bioaccumulate
biomagnify
along
food
web,
which
demands
investigations.
Currently
there
no
health
risk
assessment
human
exposure
probably
due
lack
reference
threshold
values.
Hence,
establishing
values
should
long-term
continuing
task
scientific
community.
Recent
progress
quantifying
vertical
settling
deep
brightened
prospect
finding
"Missing
Plastics",
at
least
partially.
Future
efforts
are
urgently
needed
developing
novel
techniques,
conducting
additional
laboratory
field
measurements,
formulating
robust
models
understand
occurrence,
fate,
effects
on
planet.
Toxicology Reports,
Год журнала:
2025,
Номер
14, С. 102013 - 102013
Опубликована: Апрель 1, 2025
The
harmful
environmental
impact
of
plastic
waste
has
justifiably
received
substantial
attention
from
the
scientific
community.
In
contrast,
toxicological
effects
nanoplastics
(NP)
on
aquatic
organisms,
as
well
potential
implications
for
human
health,
remain
largely
unexplored
and
poorly
understood.
Despite
growing
awareness
pollution,
risks
associated
with
ubiquitous
presence
in
our
food
beverages
are
not
yet
fully
recognized.
NPs,
which
smaller
than
1
µm,
along
a
mixture
MPs
fragments,
can
find
their
way
into
water
bodies
through
various
sources
may
easily
be
taken
up
by
organisms.
This
paper
summarizes
existing
literature
NPs
bioavailability,
accumulation
patterns
within
tissues
fish,
shellfish,
zooplankton,
influence
biological
factors
absorption
diet.
Study
indicated
that
pose
significant
to
both
ecosystems
health
due
ability
bioaccumulate
marine
organisms
biomagnify
web.
It
highlighted
species
ingest
leading
distribution
across
different
tissues,
result
toxic
such
oxidative
stress,
DNA
damage,
inflammation,
impacts
growth
reproduction.
identified
critical
gaps
current
research,
particularly
regarding
long-term
low-dose
NP
exposure
need
standardized
testing
methodologies
ensure
comparability
studies.
Furthermore,
necessity
further
research
understand
pathways
humans
exposed
toxicokinetics,
chronic
issues.
Therefore,
more
studies
required
employ
rigorous
uniform
address
an
emerging
threat
chains;
accurately
assess
related
together
cumulative
toxicity
perhaps
when
combined
other
pollutants.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Research
on
nanoplastic
(NP)
toxicity
and
their
"carrier
effects"
human
health
remains
nascent,
especially
for
real-time,
in
situ
monitoring
of
metabolic
reactions
live
cells.
Herein,
we
developed
smart
surface-enhanced
Raman
spectroscopy
(SERS)
slides
using
a
cyclic
centrifugation-enhanced
electrostatic
loading
(CCEL)
method
to
facilitatively
track
live-cell
signals.
The
designed
core-shell
polystyrene
NPs
(mPS)
with
embedded
probes
successfully
identified
intracellular
accumulation
via
distinct
Raman-silent
peak.
SERS
slide
effectively
monitored
the
changes
induced
by
mPS
at
molecular
level,
distinguishing
different
stages
membrane
interaction,
endocytosis
process,
endosomal
aggregation,
cell
apoptosis.
Besides,
this
platform
was
employed
perform
comparison
cycle
alterations
bare
effects",
revealing
that
extended
both
S
G2
phases
BEAS-2B
cells,
while
further
prolonged
disrupted
S-phase
progression.
Additionally,
integrated
machine
learning
algorithms
accurately
predict
impacts
associated
effects".
This
study
provides
label-free,
situ,
real-time
NP-induced
laying
groundwork
investigation
into
cytotoxic
behaviors
strategies
mitigate
NP
toxicity.
International Journal of Biological Sciences,
Год журнала:
2024,
Номер
20(14), С. 5779 - 5792
Опубликована: Окт. 21, 2024
The
escalation
of
plastic
pollution
represents
a
global
environmental
and
health
problem.
Important
toxic
effects
have
been
attributed
to
the
increasing
diffusion
microplastics
(MPs)
nanoplastics
(NPs)
derived
from
degradation
plastics.
These
particles
ubiquitously
observed
in
environment,
with
humans
being
continuously
exposed
via
ingestion,
inhalation
skin
contact.
Nonetheless,
cellular
homeostasis
imbalance
induced
by
micro-
nano-
plastics
(MNPs)
human
has
only
recently
shown,
while
most
evidence
molecular
mechanisms
studies
Environmental Science & Technology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 16, 2024
Plastic
pollution
is
a
significant
environmental
concern
globally.
Plastics
are
normally
considered
chemically
inert
and
resistant
to
biodegradation.
Although
many
papers
have
reported
enzyme-induced
biodegradation
of
plastics,
these
studies
primarily
limited
enzymes
microbial
origin
or
engineered
enzymes.
This
study
reveals
that
poly(ethylene
terephthalate)
(PET,
∼6000
Da
100
kDa)
particles
plastic
bottle
debris
(PBD,
24.9
can
be
efficiently
degraded
by
mammal-origin
natural
phase
II
metabolic
isozyme,
glutathione
S-transferase
(GST),
under
mild
conditions.
The
degradation
efficiency
PET
plastics
reached
98.9%,
with
rate
2.6
g·L–1·h–1
ambient
physiological
conditions
at
1
atm.
GST
varying
biological
factors
(i.e.,
temperature,
light
irradiation,
pH,
presence
humic
acid
protein).
We
suggest
novel
mechanism
for
other
than
hydrolysis,
i.e.,
the
cleavage
release
monomers
via
nitridation
oxidation.
finding
also
function
GST,
previously
thought
only
degrade
small
molecules
(<1000
Da).
method
has
been
successfully
applied
in
real
human
serum
samples.
Additionally,
we
tested
confirmed
ability
digestive
enzyme
(trypsin)
human-derived
(CYP450).
Overall,
our
findings
provide
potential
new
route
control
contribute
understanding
metabolism
fate
organisms.
