TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response DOI Creative Commons

Baopeng Xing,

Hainan Lan,

Haifeng Li

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117200 - 117200

Опубликована: Окт. 30, 2024

Язык: Английский

Impact of 1,2-Bis (2,4,6-Tribromophenoxy) Ethane on Liver Metabolism and Intestinal Health in Zebrafish: Role of the Liver X Receptor DOI
Biran Zhu, Qianqian Zhang, Xianglin Chen

и другие.

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

1,2-Bis (2,4,6-tribromophenoxy) ethane (BTBPE) has been increasingly detected in environmental and biota samples, primarily accumulating the liver. However, mechanism underlying BTBPE-induced metabolic dysregulation remains unclear. In this study, molecular docking microscale thermophoresis assays indicated that BTBPE binds to zebrafish liver X receptor α (LXRα). Subsequently, embryos were exposed BTBPE, an LXR antagonist (GSK2033), or coexposed with agonist (GW3965) for 120 h postfertilization (hpf). The results showed induced reduction body weight lipid levels, likely via inhibition of signaling pathway. Exposure adult female environmentally relevant concentrations (0.01-10 μg/L) 28 days developmental toxicity, evidenced by decreases weight, growth rate, fat accumulation. Metabolomic analysis revealed alterations metabolites associated LXR-mediated pathways such as glycerophospholipid metabolism primary bile acid biosynthesis. Additionally, impaired physical barrier inflammation, resulting gut microbiota dysbiosis, which is potentially linked activation. These effects validated through multiple biomarkers at various levels. Overall, our suggest disrupts function

Язык: Английский

Процитировано

0
Toxic effects of polystyrene microplastics on atrazine in zebrafish: Exogenous toxicity and endogenous mechanism DOI
Zihang Zeng,

Lixiang Chen,

Ruixiang Li

и другие.

Environmental Pollution, Год журнала: 2025, Номер unknown, С. 126519 - 126519

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Environmental Levels of Bis(2-ethylhexyl)-tetrabromophthalate (TBPH) Cause Thyroid Toxicity and Early Carcinogenic Signals in Juvenile Fish DOI
Xiangsheng Hong, Liang Yan, Wei Sang

и другие.

Environmental Pollution, Год журнала: 2025, Номер 380, С. 126568 - 126568

Опубликована: Май 29, 2025

Язык: Английский

Процитировано

0
Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats DOI

Yuese Yuan,

Yimeng Zhuang,

Yuan Cui

и другие.

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 490, С. 117020 - 117020

Опубликована: Июль 3, 2024

Язык: Английский

Процитировано

1
TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response DOI Creative Commons

Baopeng Xing,

Hainan Lan,

Haifeng Li

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 286, С. 117200 - 117200

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

0