Impact of 1,2-Bis (2,4,6-Tribromophenoxy) Ethane on Liver Metabolism and Intestinal Health in Zebrafish: Role of the Liver X Receptor

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: April 25, 2025

1,2-Bis (2,4,6-tribromophenoxy) ethane (BTBPE) has been increasingly detected in environmental and biota samples, primarily accumulating the liver. However, mechanism underlying BTBPE-induced metabolic dysregulation remains unclear. In this study, molecular docking microscale thermophoresis assays indicated that BTBPE binds to zebrafish liver X receptor α (LXRα). Subsequently, embryos were exposed BTBPE, an LXR antagonist (GSK2033), or coexposed with agonist (GW3965) for 120 h postfertilization (hpf). The results showed induced reduction body weight lipid levels, likely via inhibition of signaling pathway. Exposure adult female environmentally relevant concentrations (0.01-10 μg/L) 28 days developmental toxicity, evidenced by decreases weight, growth rate, fat accumulation. Metabolomic analysis revealed alterations metabolites associated LXR-mediated pathways such as glycerophospholipid metabolism primary bile acid biosynthesis. Additionally, impaired physical barrier inflammation, resulting gut microbiota dysbiosis, which is potentially linked activation. These effects validated through multiple biomarkers at various levels. Overall, our suggest disrupts function

Language: Английский

Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 490, P. 117020 - 117020

Published: July 3, 2024

Language: Английский

TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 286, P. 117200 - 117200

Published: Oct. 30, 2024

Language: Английский