Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Год журнала: 2024, Номер 949, С. 175057 - 175057

Опубликована: Июль 26, 2024

Язык: Английский

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Exposure to 6-PPD quinone disrupts glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans

Chemosphere, Год журнала: 2024, Номер 363, С. 142975 - 142975

Опубликована: Июль 29, 2024

Язык: Английский

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Exploring the Fate of 6PPD in Zebrafish (Danio rerio): Understanding Toxicokinetics, Biotransformation Mechanisms, and Metabolomic Profiling at Environmentally Relevant Levels

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137687 - 137687

Опубликована: Фев. 20, 2025

Язык: Английский

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Chronic Toxicity Mechanisms of 6PPD and 6PPD-Quinone in Zebrafish

Environmental Science and Ecotechnology, Год журнала: 2025, Номер 25, С. 100567 - 100567

Опубликована: Май 1, 2025

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) and its oxidation derivative, 6PPD-quinone (6PPDQ), have been extensively detected in environmental biological samples, raising significant concerns regarding their chronic aquatic toxicity at environmentally relevant concentrations. However, the underlying mechanisms driving this remain largely unexplored. Here we show that zebrafish exposed to 6PPD 6PPDQ exhibit distinct toxicokinetic profiles, with preferentially accumulating liver predominantly targeting brain. Exposure both compounds impaired growth, induced hepatic damage, disrupted locomotor behavior. Transcriptomic analysis of tissue revealed disturbances lipid carbohydrate metabolic pathways treatment groups, differences gene expression patterns biochemical responses between 6PPDQ. Specifically, downregulated peroxisome proliferator-activated receptor gamma (PPARγ) elevated pro-inflammatory cytokines (TNF-α IL-6). Molecular dynamics simulations surface plasmon resonance experiments further demonstrated hepatotoxicity was associated direct binding these PPARγ, a critical regulator metabolism inflammation. Our findings highlight hepatotoxic risks life. Importantly, exhibited greater compared 6PPD, emphasizing an urgent need for targeted controls regulatory actions mitigate ecological harm potential public health consequences.

Язык: Английский

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6-PPD quinone at environmentally relevant concentrations induces immunosenescenece by causing immunosuppression during the aging process

Chemosphere, Год журнала: 2024, Номер 368, С. 143719 - 143719

Опубликована: Ноя. 1, 2024

Язык: Английский

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Characterizing the Metabolism of Tire Rubber-Derived p-Phenylenediamine Quinones to Identify Potential Exposure Biomarkers in Humans

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 5, 2024

There is growing evidence of the frequent detection tire rubber-derived contaminants

Язык: Английский

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Environmental occurrence, fate, human exposure, and human health risks of p-phenylenediamines and their quinones

The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177742 - 177742

Опубликована: Ноя. 29, 2024

Язык: Английский

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6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

N-(1,3-Dimethylbutyl)-N′-phenyl-1,4-phenylenediamine (6PPD) and its oxidation product 6PPD-quinone (6PPDQ) showed different acute toxicities bioaccumulation potencies in fish. In this study, we compared the thyroid disrupting effects of 6PPD 6PPDQ through vitro, silico, vivo assays. Interestingly, although similar docking affinities with hormone receptor (TR) isoforms GH3 cell inhibition effects, signaling pathway, eye development, phototactic behaviors, density retinal layer larval zebrafish were significantly affected only following exposure. Further investigation demonstrates that can act as a TR antagonist to reduce opsin protein abundance inhibit cone photoreceptor proliferation, which finally alters structure causes microphthalmus zebrafish. Especially, under environmental relevant concentration exposure, induced alterations trβ, opn1lw1, opn1mw1, rpe65a, nr2e3 gene expressions no significant histopathological change was observed. This study illustrates for first time more serious visual system impairment 6PPDQ, disruption being contributing factor, while other important toxic targets still require further research.

Язык: Английский

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Effects of Polystyrene Microplastic Exposure on Liver Cell Damage, Oxidative Stress, and Gene Expression in Juvenile Crucian Carp (Carassius auratus)

Toxics, Год журнала: 2025, Номер 13(1), С. 53 - 53

Опубликована: Янв. 12, 2025

A considerable quantity of microplastic debris exists in the environment and toxicity these materials has a notable impact on aquatic ecosystems. In this paper, 50–500 µm polystyrene microplastics (exposure concentrations were 200 µg/L, 800 3200 µg/L concentrations) selected to study effects (PS-MPs) cell morphology, detoxification enzyme activity, mRNA expression liver tissues crucian carp juveniles. The results demonstrated that: (1) Different PS-MPs cause varying degrees pathological oxidative damage tissue cells carp. higher concentration microplastics, lower antioxidant (CAT, GST, SOD) activity greater damage. These demonstrate typical dose–effect relationship. (2) Principal component analysis Spearman’s correlation that four components, namely glutathione S-transferase (GST) its related genes (GSTpi, GSTα), along with catalase (CAT), contributed most observed outcome. components relatively high level responsiveness PS-MP exposure can be employed as ecotoxicological indicators microplastics. (3) This experiment evaluated five three treatments, which found had different gene tested involved response pathways associated virulence. study, was determined at cellular, protein, levels, combined principal identify sensitivity provide scientific basis for ecological risk assessment safe use

Язык: Английский

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Aggregate exposure pathways for 6PPD-quinone: A source-to-target site continuum integrating exposure and human health

Environmental Chemistry and Ecotoxicology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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